rs141138308
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we investigated the association between ApoE C112R/R158C single nucleotide polymorphisms (which determine the E2, E3, and E4 isoforms) and age-related macular degeneration (AMD), and the mechanism underlying the association.
|
16823865 |
2006 |
rs752907384
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we investigated the association between ApoE C112R/R158C single nucleotide polymorphisms (which determine the E2, E3, and E4 isoforms) and age-related macular degeneration (AMD), and the mechanism underlying the association.
|
16823865 |
2006 |
rs3024997
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One SNP (rs3024997) showed evidence of departure from Hardy-Weinberg equilibrium in only the AMD cases.
|
18079689 |
2007 |
rs833061
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In our work, we searched for an association between the -460C> (rs833061) and -634G>C (rs2010963) polymorphisms of the VEGF gene and the occurrence of AMD and its dry and wet forms.
|
19761764 |
2009 |
rs2010963
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In our work, we searched for an association between the -460C> (rs833061) and -634G>C (rs2010963) polymorphisms of the VEGF gene and the occurrence of AMD and its dry and wet forms.
|
19761764 |
2009 |
rs2146323
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The VEGF gene polymorphic SNPs at rs699947 and rs2146323 are strong determinants of the anatomic outcome after PDT, but the SNPs studied were not associated with the presence of exudative AMD or with the CNV lesion size or configuration.
|
19896188 |
2010 |
rs3025033
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequencies of 3 VEGF gene SNPs were analyzed, 1 at the promoter site (rs699947, A-->C) and 2 intronic SNPs (rs2146323, A-->C, and rs3025033, A-->G), in relation to the risk of AMD, to choroidal neovascular (CNV) lesion size and configuration, and to the anatomic response to photodynamic therapy (PDT).
|
19896188 |
2010 |
rs833069
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Two polymorphisms (rs833069</span> in intron 2 of the VEGF-A gene, rs2071559 in the promoter of the KDR gene) were significantly associated with risk of AMD.
|
20471686 |
2010 |
rs1413711
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We observed a prevalence of homozygosity (TT genotype) of 18.1% for rs1413711 among AMD cases compared with 5.8% among controls (P < 0.002).
|
21881842 |
2012 |
rs2010963
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The present meta-analyses indicated that there were no significantly associations between VEGF polymorphisms (rs833061, rs1413711, rs2010963) and the risk of AMD, although the association was different for each polymorphism among different populations.
|
22307787 |
2012 |
rs833061
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The results suggest the VEGF-A rs1413711 and rs833061 polymorphisms may contribute to AMD susceptibility.
|
23761723 |
2013 |
rs2010963
|
|
|
0.050 |
GeneticVariation |
BEFREE |
No association was observed between AMD risk and the variant genotypes of VEGF-A rs2010963 and rs3025039 polymorphisms in different genetic models.
|
23761723 |
2013 |
rs1413711
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The results suggest the VEGF-A rs1413711 and rs833061 polymorphisms may contribute to AMD susceptibility.
|
23761723 |
2013 |
rs3025039
|
|
|
0.030 |
GeneticVariation |
BEFREE |
No association was observed between AMD risk and the variant genotypes of VEGF-A rs2010963 and rs3025039 polymorphisms in different genetic models.
|
23761723 |
2013 |
rs833061
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Our study shows that VEGFA rs699947 and rs833061 and VEGFR2 rs2071559 polymorphisms do not modify the risk of suffering AMD in a Spanish population.
|
23971975 |
2013 |
rs699947
|
|
|
0.020 |
GeneticVariation |
BEFREE |
VEGF A (rs699947 and rs833061) and VEGFR2 (rs2071559) gene polymorphisms are not associated with AMD susceptibility in a Spanish population.
|
23971975 |
2013 |
rs1413711
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Genotypes of 3 polymorphisms in known AMD susceptibility loci (rs1061170 in complement factor H (CFH), rs11200638 in HTRA1 and rs1413711 in VEGF) were determined.
|
24080590 |
2013 |
rs833069
|
|
|
0.020 |
GeneticVariation |
BEFREE |
No association was found to support the role for the rs833069, rs943080 and rs4711751 variants of or near VEGFA gene in susceptibility to either PCV or neovascular AMD in Han Chinese population.
|
24303777 |
2015 |
rs833061
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The meta-analysis results based on nine case-control studies with 2427 cases and 2037 controls showed that rs833061 had protective effects on AMD risk (TT vs. CT+CC: OR=0.58, 95% CI=0.41-0.81), whereas rs1413711 (TT vs. CT+CC: OR=1.46, 95% CI=1.10-1.93) and rs3025039 (TT vs. CC: OR=1.87, 95% CI=1.15-3.02; TT vs. CT+CC: OR=2.09, 95% CI=1.30-3.37) represented as risk factors for AMD.
|
24689893 |
2014 |
rs1413711
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The meta-analysis results based on nine case-control studies with 2427 cases and 2037 controls showed that rs833061 had protective effects on AMD risk (TT vs. CT+CC: OR=0.58, 95% CI=0.41-0.81), whereas rs1413711 (TT vs. CT+CC: OR=1.46, 95% CI=1.10-1.93) and rs3025039 (TT vs. CC: OR=1.87, 95% CI=1.15-3.02; TT vs. CT+CC: OR=2.09, 95% CI=1.30-3.37) represented as risk factors for AMD.
|
24689893 |
2014 |
rs3025039
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The meta-analysis results based on nine case-control studies with 2427 cases and 2037 controls showed that rs833061 had protective effects on AMD risk (TT vs. CT+CC: OR=0.58, 95% CI=0.41-0.81), whereas rs1413711 (TT vs. CT+CC: OR=1.46, 95% CI=1.10-1.93) and rs3025039 (TT vs. CC: OR=1.87, 95% CI=1.15-3.02; TT vs. CT+CC: OR=2.09, 95% CI=1.30-3.37) represented as risk factors for AMD.
|
24689893 |
2014 |
rs2146323
|
|
|
0.020 |
GeneticVariation |
BEFREE |
VEGF rs2146323 and rs699947 SNPs have no relationship to exudative AMD formation, and none of these seem to have any effect on anti-VEGF response.
|
27404493 |
2016 |
rs699947
|
|
|
0.020 |
GeneticVariation |
BEFREE |
VEGF rs2146323 and rs699947 SNPs have no relationship to exudative AMD formation, and none of these seem to have any effect on anti-VEGF response.
|
27404493 |
2016 |
rs833061
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Significant associations with AMD risk were showed for rs833061, rs1413711, and rs3025039 polymorphisms but not for rs2010963.
|
27999450 |
2016 |
rs2010963
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The aim of the present study is to carry out a systematic review and an updated meta-analysis in order to summarize the current published studies and to evaluate the associations between four common vascular endothelial growth factor (<i>VEGF</i>) polymorphisms (rs833061, rs1413711, rs3025039, and rs2010963) and AMD risk, also stratifying for AMD subtypes and ethnicity.
|
27999450 |
2016 |