|
rs716508
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Of the SNPs, rs716508 in A2BP1 was associated with ROA (OR = 0.7, 95% CI 0.5-0.9) and rs1800470 in TGFB1 with symptomatic DIP OA (1.8, 1.2-2.9).
|
24825461 |
2014 |
|
rs9340799
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We found an interaction between ESR1 (rs9340799) and occupation: teachers with the minor allele were at an increased risk of symptomatic DIP OA (2.8, 1.3-6.5).
|
24825461 |
2014 |
|
rs77245812
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The T303M polymorphism of the MATN3 gene, which was initially described as associated with hand osteoarthritis, may be more closely linked to trapeziometacarpal osteoarthritis than to digital osteoarthritis.
|
20971668 |
2011 |
|
rs716508
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Five single-nucleotide polymorphisms (SNPs) had a likelihood of association with hand OA in the discovery stage and one of them (rs716508), was successfully confirmed in the replication stage (meta-analysis p = 1.81x10(-5)).
|
19508968 |
2009 |
|
rs9340799
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We found no significant association between our OA phenotypes or generalized or severe generalized OA as defined by Ushiyama and heterozygosity for rs2234693 and rs9340799, although in metaanalysis with the former study this heterozygosity remained significantly associated with generalized or severe generalized OA.
|
19884274 |
2009 |
|
rs77245812
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The originally described association of T303M with the hand osteoarthritis phenotype was not observed in the populations studied.
|
16396979 |
2006 |
|
rs187084
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results indicated that the A allele of rs187084 is a risk allele for HOA and is likely to be a predisposing factor leading to an increased risk of HOA (adjusted odds ratio with age, gender, and BMI = 1.26, 95% confidence interval = 1.10-1.43).
|
31066581 |
2019 |
|
rs11096957
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two significant SNPs, rs11096957 (OR = 1.26, P = 1.35 × 10<sup>-5</sup>) and rs2273650 (OR = 1.2, P = 1.57 × 10<sup>-3</sup>), were significantly associated with HOA risk.
|
29980729 |
2018 |
|
rs2273650
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two significant SNPs, rs11096957 (OR = 1.26, P = 1.35 × 10<sup>-5</sup>) and rs2273650 (OR = 1.2, P = 1.57 × 10<sup>-3</sup>), were significantly associated with HOA risk.
|
29980729 |
2018 |
|
rs781754383
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We transfected these contructs into the COS-1 or MCT cells, and the results revealed that the HOA-related matrilin-3 mutation (T298M) leads to a high expression level of growth arrest DNA damage-inducible gene 153 (GADD153, also known as CHOP; an endoplasmic reticulum stress marker), as shown by western blot analysis and does not significantly affect protein secretion, as shown by immunofluorescence staining; however, osteochondroplasia, i.e., MED-related (R116W) and SEMD-related (C299S) mutations lead to both high levels of GADD153 expression and protein trafficking into the cytoplasm and form multiple vacuoles in cells, which in turn leads to insufficient protein secretion.
|
26499313 |
2015 |
|
rs788748
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The A allele of rs788748, located 65 kb upstream of the IGFBP3 gene, was associated with lower HOA odds at the genome-wide significance level in the discovery stage (OR 0.71, p=2×10(-8)).
|
24928840 |
2015 |
|
rs179945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was also a suggestive interaction between the HFE rs179945 and the ESR1 rs9340799, and the carriage of the minor allele of either of these SNPs was associated with an increased risk of symptomatic DIP OA (2.1, 1.3-2.5).
|
24825461 |
2014 |
|
rs1800470
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of the SNPs, rs716508 in A2BP1 was associated with ROA (OR = 0.7, 95% CI 0.5-0.9) and rs1800470 in TGFB1 with symptomatic DIP OA (1.8, 1.2-2.9).
|
24825461 |
2014 |
|
rs1805013
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As far as the non-erosive hand OA group (n=159) is concerned, the significance level of association of SNP rs1805013 is increased.
|
20219689 |
2010 |
|
rs2243250
|
|
|
0.010 |
GeneticVariation |
BEFREE |
With respect to the CMC1 OA group, two SNPs in IL-4 (rs2243250 and rs2243274) showed association with a P-value of 0.027 and 0.018 respectively.
|
20219689 |
2010 |
|
rs2243274
|
|
|
0.010 |
GeneticVariation |
BEFREE |
With respect to the CMC1 OA group, two SNPs in IL-4 (rs2243250 and rs2243274) showed association with a P-value of 0.027 and 0.018 respectively.
|
20219689 |
2010 |
|
rs2234693
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found no significant association between our OA phenotypes or generalized or severe generalized OA as defined by Ushiyama and heterozygosity for rs2234693 and rs9340799, although in metaanalysis with the former study this heterozygosity remained significantly associated with generalized or severe generalized OA.
|
19884274 |
2009 |
|
rs12885713
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A functional core promoter single nucleotide polymorphism (SNP) -16C/T (rs12885713) was recently associated with hip OA (HOA) in the Japanese population, while no association was found in a British group of patients with HOA.
|
18452398 |
2008 |
|
rs752149020
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A functional core promoter single nucleotide polymorphism (SNP) -16C/T (rs12885713) was recently associated with hip OA (HOA) in the Japanese population, while no association was found in a British group of patients with HOA.
|
18452398 |
2008 |
|
rs1508632
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs1508632 lies in immediate proximity to the TINAG gene, implicating it as a possible hand osteoarthritis susceptibility gene.
|
17985653 |
2007 |
|
rs1799945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The HFE H63D variant may explain, at least in part, the prevalence of arthralgia in multiple joints sites, chondrocalcinosis, and hand osteoarthritis in the general population.
|
17284543 |
2007 |
|
rs2242190
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate SNP5 and two other promising polymorphisms (rs2242190; SNP3, rs8176070; SNP6) for association with radiographic and symptomatic hand osteoarthritis phenotypes, as well as other heritable phenotypes.
|
16396979 |
2006 |
|
rs8176070
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate SNP5 and two other promising polymorphisms (rs2242190; SNP3, rs8176070; SNP6) for association with radiographic and symptomatic hand osteoarthritis phenotypes, as well as other heritable phenotypes.
|
16396979 |
2006 |
|
rs1800562
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of heterozygous hemochromatosis C282Y gene mutation with hand osteoarthritis.
|
12508400 |
2003 |