|
rs3794087
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recently, a genome-wide association study of a Caucasian population identified variant rs3794087 in intron 4 of the SLC1A2 gene, which may increase the risk of essential tremor (ET).
|
29275184 |
2018 |
|
rs3794087
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our results showed a lack of association between rs6280 and rs3794087 with the risk for ET, though a marginal increased risk for ET was observed among the rs1052553A allele carriers, which was not confirmed with a family-based association study.
|
27456607 |
2016 |
|
rs3794087
|
|
|
0.900 |
GeneticVariation |
BEFREE |
SLC1A2 rs3794087 are associated with susceptibility to Parkinson's disease, but not essential tremor, amyotrophic lateral sclerosis or multiple system atrophy in a Chinese population.
|
27206883 |
2016 |
|
rs3794087
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Replication of two lead single nucleotide polymorphisms of previous small genome-wide association studies (rs3794087 in SLC1A2, rs9652490 in LINGO1) did not confirm the association with essential tremor.
|
27797806 |
2016 |
|
rs9652490
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Replication of two lead single nucleotide polymorphisms of previous small genome-wide association studies (rs3794087 in SLC1A2, rs9652490 in LINGO1) did not confirm the association with essential tremor.
|
27797806 |
2016 |
|
rs3794087
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The results of the meta-analysis suggest that rs3794087 is not associated with the risk for ET.
|
26313486 |
2015 |
|
rs3794087
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These findings therefore do not support a role for SLC1A2 rs3794087 in susceptibility to ET in the North American population.
|
24139280 |
2014 |
|
rs9652490
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our meta-analysis confirmed the association of rs9652490 in LINGO1 with ET.
|
24532269 |
2014 |
|
rs3794087
|
|
|
0.900 |
GeneticVariation |
BEFREE |
(4) Subsequent GWAS further identified an intronic variant (rs3794087) of the main glial glutamate transporter (SLC1A2) gene to be associated with ET with an odds ratio (OR) of approximately 1.4.
|
23596072 |
2013 |
|
rs3794087
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our study suggests that SLC1A2 rs3794087 is not associated with the risk for developing familial ET in the Spanish population, thus subtracting relevance to SLC1A2 rs3794087 as a risk biomarker for ET.
|
23949322 |
2013 |
|
rs3794087
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The results showed that rs3794087 was associated with ET among the Taiwanese.The odds ratio was 1.37.
|
23951268 |
2013 |
|
rs9652490
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The first genome-wide association study (GWAS) has identified an association of the LINGO1 variant (rs9652490) with ET in Americans and Europeans.
|
23951268 |
2013 |
|
rs3794087
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Polymorphisms in the glial glutamate transporter SLC1A2 are associated with essential tremor.
|
22764253 |
2012 |
|
rs3794087
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We verified the association of rs3794087 with ET in a second-stage sample (p = 1.25 × 10(-3), OR = 1.38).
|
22764253 |
2012 |
|
rs3794087
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Polymorphisms in the glial glutamate transporter SLC1A2 are associated with essential tremor.
|
22764253 |
2012 |
|
rs9652490
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The results of the meta-analysis suggest a relationship between LINGO1 rs11856808 polymorphism and the risk for ET and for familial ET, while rs9652490 polymorphism was only related with the risk for familial ET.
|
22425540 |
2012 |
|
rs9652490
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recently, the first genome-wide association study in ET followed by replication studies conducted in diverse populations identified a significant association between the leucine-rich repeat and Ig domain containing 1 gene (LINGO1) SNP rs9652490 and risk for ET Although further novel variants were indentified in LINGO1 and its paralog LINGO2 that may be associated with risk for ET, the pathogenic mechanisms involved remain elusive.
|
22166413 |
2012 |
|
rs9652490
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recently, rs9652490 variant in the leucine-rich repeat and Ig domain containing 1 gene (LINGO1) was found to be associated with ET susceptibility.
|
20951767 |
2011 |
|
rs9652490
|
|
|
0.900 |
GeneticVariation |
BEFREE |
CONCLUSION - While we could not demonstrate a significant association of the rs9652490 variant in our own study, pooled analysis of a much larger cohort revealed for the first time that the variant increased the risk in both familial and sporadic forms of ET among Asians, though the effect was stronger in familial ET.
|
21158743 |
2011 |
|
rs9652490
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our genotyping results lead us to conclude that no association exists between the key variant rs9652490 and ET (P(corr) = 1.00).
|
21264305 |
2011 |
|
rs9652490
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The first genome-wide association study in ET showed a significant association with the rs9652490 SNP of the leucine-rich repeat and Ig domain containing 1 (LINGO1) gene.
|
21752692 |
2011 |
|
rs9652490
|
|
|
0.900 |
GeneticVariation |
BEFREE |
However, for 'definite' or 'probable' ET, rs9652490 was significantly associated with ET (P=0.03, OR=1.41).
|
20372186 |
2010 |
|
rs9652490
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our study demonstrates a significant association between LINGO1 rs9652490 and essential tremor (P = 0.014) and Parkinson disease (P = 0.0003), thus providing the first evidence of a genetic link between both diseases.
|
19720553 |
2010 |
|
rs9652490
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We concluded that the two markers rs9652490 and rs11856808 were not strongly related to the development of ET or late onset SPD, but the rs9652490G allele might be a protective factor for EOPD in Chinese population.
|
20600614 |
2010 |
|
rs9652490
|
|
|
0.900 |
GeneticVariation |
BEFREE |
One variant in LINGO1 (rs9652490) displayed evidence of an association with ET (odds ratio (OR) =0.63; P=0.026) and PD (OR=0.54; P=0.016).
|
20369371 |
2010 |