Gene: LUM ×
Source: BEFREE ×
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3759223
rs3759223
LUM
0.060 GeneticVariation BEFREE The results indicated that rs3759223 polymorphism was associated with high myopia under a recessive model (OR = 1.71, 95%CI 1.04-2.81). 24956166

2014
dbSNP: rs3759223
rs3759223
LUM
0.060 GeneticVariation BEFREE This meta-analysis has suggested that there is a lack of association of the rs3759223 polymorphism with high myopia risk. 24927138

2014
dbSNP: rs3759223
rs3759223
LUM
0.060 GeneticVariation BEFREE Chinese lumican rs3759223 C allele carriers may be at reduced risk of high myopia. 24516061

2014
dbSNP: rs3759223
rs3759223
LUM
0.060 GeneticVariation BEFREE This meta-analysis showed the evidence that SNP rs3759223 may affect individual susceptibility to high myopia in the Chinese population. 24061151

2013
dbSNP: rs3759223
rs3759223
LUM
0.060 GeneticVariation BEFREE Genetic variation in the regulatory domains of the lumican gene, where both rs3759223 and rs3741834 are located, are associated with high myopia susceptibility among the Han Chinese, making this region worthy of further investigation. 19616852

2009
dbSNP: rs3759223
rs3759223
LUM
0.060 GeneticVariation BEFREE Our results indicate that an SNP (rs3759223), which is located in the promoter region of the lumican gene, may be worth further investigation to determine its association with development of high myopia. 16902402

2006
dbSNP: rs3759222
rs3759222
LUM
0.010 GeneticVariation BEFREE Four studies (1024 cases and 1163 controls) were identified for the analysis of the association between rs3759222 polymorphism and high myopia. 24956166

2014
dbSNP: rs3741834
rs3741834
LUM
0.010 GeneticVariation BEFREE Genetic variation in the regulatory domains of the lumican gene, where both rs3759223 and rs3741834 are located, are associated with high myopia susceptibility among the Han Chinese, making this region worthy of further investigation. 19616852

2009
dbSNP: rs747899454
rs747899454
LUM
0.010 GeneticVariation BEFREE Five changes were detected in opticin, Thr177Arg, Arg229His, Arg325Trp, Gly329Ser, and Arg330His, and all but one (Arg229His) were shown to cosegregate with high myopia in families with incomplete penetrance. 17117407

2007