| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.020 | GeneticVariation | BEFREE | Meta-analysis of existing data revealed a suggestive association of PAX6 rs644242 with extreme and high myopia, which awaits validation in further studies. | 24637479 | 2014 |
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0.020 | GeneticVariation | BEFREE | After adjusting for age and sex, evaluation of cataract control showed a marginal association with high myopia in rs644242 (odds ratio [95% confidence interval]=0.69 [0.49-0.96], p=0.026), and a significant association was observed in healthy Japanese controls (0.79 [0.66-0.96], p=0.015). | 23213273 | 2012 |
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0.010 | GeneticVariation | BEFREE | We showed previously that single nucleotide polymorphism (SNP) rs662702 in PAX6 may be located in a microRNA-328 binding site that causes susceptibility to high myopia. | 22447870 | 2012 |
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0.010 | GeneticVariation | BEFREE | However, exhaustive sliding-window haplotype analysis highlighted an important role for rs12421026 because haplotypes containing this SNP were found to be associated with high myopia. | 21589860 | 2011 |
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|
0.010 | GeneticVariation | BEFREE | Single marker analysis of SNPs rs3026390 and rs3026393 showed significant association with high myopia as a qualitative trait in dominant and recessive models (P = 0.0014 and P = 0.0011, respectively). | 19124844 | 2009 |
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|
0.010 | GeneticVariation | BEFREE | Single marker analysis of SNPs rs3026390 and rs3026393 showed significant association with high myopia as a qualitative trait in dominant and recessive models (P = 0.0014 and P = 0.0011, respectively). | 19124844 | 2009 |
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|
0.010 | GeneticVariation | BEFREE | Our aim was to determine whether PAX6polymorphism at position -12 of intron 9 (IVS9-12C to T, rs667773) is associated with high myopia in Chinese Taiwanese. | 17948041 | 2008 |