|
rs12150220
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This meta-analysis demonstrates that within the Caucasian population, the NLRP1 rs12150220 polymorphism may correlate with a decreased risk of vitiligo-associated autoimmune diseases, especially autoimmune Addison's disease, type 1 diabetes, or systemic lupus erythematosus.
|
29152150 |
2017 |
|
rs1990760
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The major AA genotype of the coding SNP rs1990760 appeared significantly more frequently in AAD compared with healthy individuals (AG vs AA OR 0·62, 95%CI 0·40-0·95, P = 0·03).
|
22789000 |
2013 |
|
rs1990760
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This meta-analysis demonstrates that the IFIH1 rs1990760 T-allele confers susceptibility to T1D, SLE, MS and RA and suggests that the IFIH1 rs1990760 polymorphism might have no effect on GD and AAD.
|
23734776 |
2013 |
|
rs12150220
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The frequency of high-risk genotype AA of rs1</span>2150220 SNP was significantly increased among AAD subjects versus controls (p = 0.006 and p = 0.036, respectively; significant after Bonferroni correction), yielding an OR of 2.96 (95% CI, 1.34-6.55).
|
20152874 |
2010 |
|
rs3757247
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We aimed to determine whether alleles of the rs3757247 single nucleotide polymorphism (SNP) in the BACH2 gene are associated with AAD.
|
27680876 |
2016 |
|
rs1896286
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A three-marker haplotype, comprising PROMOTER_1661, rs231726 and rs1896286 was found to be associated with AAD in the Norwegian cohort only (OR 2.43 (CI 1.68-3.51), P=0.00013).
|
26204230 |
2015 |
|
rs2104286
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association of AAD with IL2 and IL2RA polymorphisms (rs6822844, rs2069762, rs3136534, rs11594656, rs3118470 and rs2104286) was tested in 223 patients and 672 healthy controls.
|
25347332 |
2015 |
|
rs231726
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A three-marker haplotype, comprising PROMOTER_1661, rs231726 and rs1896286 was found to be associated with AAD in the Norwegian cohort only (OR 2.43 (CI 1.68-3.51), P=0.00013).
|
26204230 |
2015 |
|
rs231775
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G-allele of SNP rs231775 in CTLA-4 is associated with AAD in Norwegian patients (odds ratio (OR)=1.35 (confidence interval (CI) 1.10-1.66), P=0.004), but not in UK patients.
|
26204230 |
2015 |
|
rs3118470
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association of AAD with IL2 and IL2RA polymorphisms (rs6822844, rs2069762, rs3136534, rs11594656, rs3118470 and rs2104286) was tested in 223 patients and 672 healthy controls.
|
25347332 |
2015 |
|
rs3136534
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The frequency of the minor C allele of rs3136534 was significantly decreased in AAD subjects compared to controls (OR 0.71; 95%CI 0.561-0.887; p = 0.003).
|
25347332 |
2015 |
|
rs3827440
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using a dominant (present/absent) model, the serine-encoding T allele of rs3827440 was present in 189 of 286 AAD patients (66%) compared with 132 of 288 unaffected controls (46%) [P = .010, odds ratio 1.80 (5%-95% confidence interval 1.22-2.67)].
|
25295623 |
2015 |
|
rs6822844
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association of AAD with IL2 and IL2RA polymorphisms (rs6822844, rs2069762, rs3136534, rs11594656, rs3118470 and rs2104286) was tested in 223 patients and 672 healthy controls.
|
25347332 |
2015 |
|
rs10931481
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We report significant association with alleles of two STAT4 markers in AAD cohorts (rs4274624: P = 0.00016; rs10931481: P = 0.0007).
|
24614117 |
2014 |
|
rs4274624
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We report significant association with alleles of two STAT4 markers in AAD cohorts (rs4274624: P = 0.00016; rs10931481: P = 0.0007).
|
24614117 |
2014 |
|
rs6473
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Heterozygotes of the single-nucleotide polymorphisms (SNPs) rs397515394, rs6467, rs6474, rs76565726 and rs6473 were detected significantly more frequently in AAD patients compared with HC (P<0.005), but all SNPs were in a linkage disequilibrium (LD) with high-risk HLA-DRB1 haplotypes. rs6472C protected against AAD (odds ratio=0.15, 95% CI (0.08-0.30), P=3.8×10(-10)).
|
25249698 |
2014 |
|
rs13422767
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We analysed the association of rs3747517, rs1990760, rs2111485 and rs13422767 single-nucleotide polymorphisms (SNPs) in the IFIH1 gene and intergenic region with AAD in a Polish cohort.
|
22789000 |
2013 |
|
rs2111485
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We analysed the association of rs3747517, rs1990760, rs2111485 and rs13422767 single-nucleotide polymorphisms (SNPs) in the IFIH1 gene and intergenic region with AAD in a Polish cohort.
|
22789000 |
2013 |
|
rs763361
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The susceptibility 'T' allele at rs763361 was found in 50·5% of patients with AAD compared to 46·5% of controls (P-value 0·16, OR 1·17; 95% CI 0·94-1·46).
|
21521299 |
2011 |
|
rs2476601
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Previous studies of the association between autoimmune Addison's disease (AAD) and a nonsynonymous single nucleotide polymorphism (SNP) in the PTPN22 gene (C1858T, pR620W; SNP ID no. rs2476601) have shown conflicting results.
|
18710467 |
2009 |