Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs753523115
rs753523115
SLC12A3
0.010 GeneticVariation BEFREE Additionally, one mutation site (c.1456G>A) in SLC12A3 gene was found in his father, paternal uncle and elder female cousin, who were complicated by subclinical hypothyroidism or autoantibody against thyroid. 30084681

2018
dbSNP: rs732609
rs732609
TPO
0.010 GeneticVariation BEFREE The findings showed that the chance (odds ratio) of developing subclinical hypothyroidism in individuals who had C alleles was 1.5 and 5.6-fold higher than in individuals without these alleles in the A2095C and A2173C regions, respectively. 28500830

2017
dbSNP: rs200000982
rs200000982
DUOX2
0.010 GeneticVariation BEFREE One child with SH showed the Y1150C mutation, and another euthyroid child showed the A728T mutation. 21565790

2011
dbSNP: rs57659670
rs57659670
DUOX2
0.010 GeneticVariation BEFREE One child with SH showed H678R, R701Q, and P982A substitutions, and another child with SH showed only the P982A. 21565790

2011
dbSNP: rs61730030
rs61730030
DUOX2
0.010 GeneticVariation BEFREE One child with SH showed H678R, R701Q, and P982A substitutions, and another child with SH showed only the P982A. 21565790

2011
dbSNP: rs189261858
rs189261858
TSHR ; LOC101928462
0.010 GeneticVariation BEFREE Heterozygous mutation R450H was the cause of subclinical hypothyroidism. 21714469

2010
dbSNP: rs1294870139
rs1294870139
TSHR ; LOC101928462
0.010 GeneticVariation BEFREE To establish the role of new TSH receptor (TSHr) variants (P27T, E34 K, R46P, D403N, W488R and M527T) recently identified in children with congenital hypothyroidism (CH) or subclinical hypothyroidism (SH) with a thyroid gland of normal size. 18727713

2009
dbSNP: rs139892516
rs139892516
TSHR ; LOC101928462
0.010 GeneticVariation BEFREE To establish the role of new TSH receptor (TSHr) variants (P27T, E34 K, R46P, D403N, W488R and M527T) recently identified in children with congenital hypothyroidism (CH) or subclinical hypothyroidism (SH) with a thyroid gland of normal size. 18727713

2009
dbSNP: rs4704397
rs4704397
PDE8B
0.010 GeneticVariation BEFREE Genetic variation in TSH levels in pregnancy associated with the PDE8B rs4704397 genotype has implications for the number of women treated for subclinical hypothyroidism under current guidelines. 19820008

2009
dbSNP: rs121908869
rs121908869
TSHR ; CEP128
0.010 GeneticVariation BEFREE A single grossly mutated allele (such as C41S or 555-561del) invariably leads to a condition of subclinical hypothyroidism, whereas in case of heterozygous carriers of mutations partially affecting the receptor function (such as P162A or L252P), a remarkable variable expressivity was detected among individuals belonging to different generations. 16060907

2005