|
rs1676486
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A single-nucleotide polymorphism (c.4603C-->T [rs1676486]) had the most significant association with LDH (P=3.3 x 10(-6)), and the transcript containing the disease-associated allele was decreased because of its decreased stability.
|
17999364 |
2007 |
|
rs17576
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Further, a missense SNP in MMP9 (Q279R; rs17576) is also strongly associated with LDH in the Japanese population (p = 0.00049) and shows a combinatorial effect with THBS2 (odds ratio 3.03, 95% confidence interval 1.58-5.77).
|
18455130 |
2008 |
|
rs9406328
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An intronic SNP in THBS2 (IVS10-8C --> T; rs9406328) showed significant association (p = 0.0000028) with LDH in two independent Japanese populations.
|
18455130 |
2008 |
|
rs1400328611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The eNOS (-786 T/C) and iNOS (22 G/A) SNPs were more frequent among the control subjects, suggesting their possible protective role against LDH.
|
21837414 |
2011 |
|
rs375081888
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The eNOS (-786 T/C) and iNOS (22 G/A) SNPs were more frequent among the control subjects, suggesting their possible protective role against LDH.
|
21837414 |
2011 |
|
rs762704392
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The eNOS (-786 T/C) and iNOS (22 G/A) SNPs were more frequent among the control subjects, suggesting their possible protective role against LDH.
|
21837414 |
2011 |
|
rs4680
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conclude that the functional COMT Val158Met SNP contributes to long lasting low back pain, sciatica and disability after lumbar disc herniation.
|
22337560 |
2012 |
|
rs1799971
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Pain intensity the first year after lumbar disc herniation is associated with the A118G polymorphism in the opioid receptor mu 1 gene: evidence of a sex and genotype interaction.
|
22815498 |
2012 |
|
rs1676486
|
|
|
0.020 |
GeneticVariation |
BEFREE |
AEI at rs1676486 is a risk factor for LDH, but not for OA.
|
23497244 |
2013 |
|
rs2615977
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This corresponded with observations in LDH but the SNP was not associated with OA.We did not observe AEI at rs2615977.
|
23497244 |
2013 |
|
rs143383
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of the present study is to assess whether the single nucleotide polymorphism in the GDF5 (+104T/C; rs143383) is associated with the symptomatic lumbar disc herniation in the Chinese Han population and the identification of the mechanisms of its action.
|
24105021 |
2014 |
|
rs6651255
|
|
|
0.710 |
GeneticVariation |
BEFREE |
In light of presented findings, we speculate that the effect of rs6651255 on LDHsurg is driven by susceptibility to developing severe and persistent sciatica upon LDH.
|
28223688 |
2017 |
|
rs6651255
|
|
|
0.710 |
GeneticVariation |
GWASCAT |
In light of presented findings, we speculate that the effect of rs6651255 on LDHsurg is driven by susceptibility to developing severe and persistent sciatica upon LDH.
|
28223688 |
2017 |
|
rs10767664
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rs11030064 in BDNFOS gene was associated with modified susceptibility for LDH at age ≤50 years but three loci (rs6265, rs11030104 and rs10767664) of BDNF gene increased LDH risk at age >50 years.
|
30143695 |
2018 |
|
rs11030064
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis shown that haplotype "GCC" in the block (rs988712, rs7481311, and rs11030064) increased LDH risk (OR = 1.49, 95% CI = 1.06-2.10, p = 0.022) at age ≤50 years.
|
30143695 |
2018 |
|
rs11030096
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further, rs11030096 polymorphism in BDNFOS gene was associated with LDH the increased susceptibility of LDH in females.
|
30143695 |
2018 |
|
rs11030104
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rs11030064 in BDNFOS gene was associated with modified susceptibility for LDH at age ≤50 years but three loci (rs6265, rs11030104 and rs10767664) of BDNF gene increased LDH risk at age >50 years.
|
30143695 |
2018 |
|
rs6265
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rs11030064 in BDNFOS gene was associated with modified susceptibility for LDH at age ≤50 years but three loci (rs6265, rs11030104 and rs10767664) of BDNF gene increased LDH risk at age >50 years.
|
30143695 |
2018 |
|
rs7481311
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis shown that haplotype "GCC" in the block (rs988712, rs7481311, and rs11030064) increased LDH risk (OR = 1.49, 95% CI = 1.06-2.10, p = 0.022) at age ≤50 years.
|
30143695 |
2018 |
|
rs4633
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We have identified a significant SNP of COMT, rs4633, which is associated with symptomatic LDH in a large Chinese Han-based sample of the study subjects.
|
30158547 |
2018 |
|
rs11066028
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, the haplotype "GGCTCACG" constructed by rs886205, rs2238152, rs4648328, rs441, rs4646778, rs671, rs11066028, and rs7296651 was associated with increased risk of LDH (OR = 1.45; 95% CI = 1.11-1.90; P = 0.0071).
|
30166580 |
2018 |
|
rs671
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the allele model analysis, we found the frequency of the "A" allele of rs671 was significantly higher in LDH cases than in controls (OR = 1.414, 95%CI: 1.109-1.803, P = 0.005).
|
30166580 |
2018 |
|
rs7296651
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, the haplotype "GGCTCACG" constructed by rs886205, rs2238152, rs4648328, rs441, rs4646778, rs671, rs11066028, and rs7296651 was associated with increased risk of LDH (OR = 1.45; 95% CI = 1.11-1.90; P = 0.0071).
|
30166580 |
2018 |
|
rs886205
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, the haplotype "GGCTCACG" constructed by rs886205, rs2238152, rs4648328, rs441, rs4646778, rs671, rs11066028, and rs7296651 was associated with increased risk of LDH (OR = 1.45; 95% CI = 1.11-1.90; P = 0.0071).
|
30166580 |
2018 |
|
rs17576
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results indicated that the A allele of rs17576 reduced the risk of LDH by ∼23% on average.
|
30289281 |
2018 |