|
rs10490571
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the recessive model (CT/CC versus TT, OR=3.43, 95% CI: 1.11-10.57, P=0.020) of rs10490571 was associated with an increased LDH risk among people older than 50 years of age.
|
31104063 |
2019 |
|
rs10767664
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rs11030064 in BDNFOS gene was associated with modified susceptibility for LDH at age ≤50 years but three loci (rs6265, rs11030104 and rs10767664) of BDNF gene increased LDH risk at age >50 years.
|
30143695 |
2018 |
|
rs10998461
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the haplotype analysis, the haplotype "GT" in block (rs10998461 and rs10998468) decreased LDH risk (OR = 0.7, 95% CI = 0.52-0.93, p = .016).
|
31724315 |
2020 |
|
rs10998468
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the haplotype analysis, the haplotype "GT" in block (rs10998461 and rs10998468) decreased LDH risk (OR = 0.7, 95% CI = 0.52-0.93, p = .016).
|
31724315 |
2020 |
|
rs11030064
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis shown that haplotype "GCC" in the block (rs988712, rs7481311, and rs11030064) increased LDH risk (OR = 1.49, 95% CI = 1.06-2.10, p = 0.022) at age ≤50 years.
|
30143695 |
2018 |
|
rs11030096
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further, rs11030096 polymorphism in BDNFOS gene was associated with LDH the increased susceptibility of LDH in females.
|
30143695 |
2018 |
|
rs11030104
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rs11030064 in BDNFOS gene was associated with modified susceptibility for LDH at age ≤50 years but three loci (rs6265, rs11030104 and rs10767664) of BDNF gene increased LDH risk at age >50 years.
|
30143695 |
2018 |
|
rs11066028
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, the haplotype "GGCTCACG" constructed by rs886205, rs2238152, rs4648328, rs441, rs4646778, rs671, rs11066028, and rs7296651 was associated with increased risk of LDH (OR = 1.45; 95% CI = 1.11-1.90; P = 0.0071).
|
30166580 |
2018 |
|
rs1400328611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The eNOS (-786 T/C) and iNOS (22 G/A) SNPs were more frequent among the control subjects, suggesting their possible protective role against LDH.
|
21837414 |
2011 |
|
rs143383
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of the present study is to assess whether the single nucleotide polymorphism in the GDF5 (+104T/C; rs143383) is associated with the symptomatic lumbar disc herniation in the Chinese Han population and the identification of the mechanisms of its action.
|
24105021 |
2014 |
|
rs1676486
|
|
|
0.020 |
GeneticVariation |
BEFREE |
AEI at rs1676486 is a risk factor for LDH, but not for OA.
|
23497244 |
2013 |
|
rs1676486
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A single-nucleotide polymorphism (c.4603C-->T [rs1676486]) had the most significant association with LDH (P=3.3 x 10(-6)), and the transcript containing the disease-associated allele was decreased because of its decreased stability.
|
17999364 |
2007 |
|
rs17576
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our results indicated that the A allele of rs17576 reduced the risk of LDH by ∼23% on average.
|
30289281 |
2018 |
|
rs17576
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Further, a missense SNP in MMP9 (Q279R; rs17576) is also strongly associated with LDH in the Japanese population (p = 0.00049) and shows a combinatorial effect with THBS2 (odds ratio 3.03, 95% confidence interval 1.58-5.77).
|
18455130 |
2008 |
|
rs1799971
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Pain intensity the first year after lumbar disc herniation is associated with the A118G polymorphism in the opioid receptor mu 1 gene: evidence of a sex and genotype interaction.
|
22815498 |
2012 |
|
rs2615977
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This corresponded with observations in LDH but the SNP was not associated with OA.We did not observe AEI at rs2615977.
|
23497244 |
2013 |
|
rs375081888
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The eNOS (-786 T/C) and iNOS (22 G/A) SNPs were more frequent among the control subjects, suggesting their possible protective role against LDH.
|
21837414 |
2011 |
|
rs4472827
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results provide evidence for polymorphisms of rs7903209 and rs4472827 in STOX1 associated with LDH risk in Chinese Han population.
|
31724315 |
2020 |
|
rs45437897
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNP rs17576 was found to be significantly associated with susceptibility to LDH (OR = 0.77, p = 0.0002), which was also confirmed by haplotype-based analyses (rs79845319-rs17576-rs45437897, global p < 0.001).
|
30289281 |
2018 |
|
rs4633
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We have identified a significant SNP of COMT, rs4633, which is associated with symptomatic LDH in a large Chinese Han-based sample of the study subjects.
|
30158547 |
2018 |
|
rs4680
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conclude that the functional COMT Val158Met SNP contributes to long lasting low back pain, sciatica and disability after lumbar disc herniation.
|
22337560 |
2012 |
|
rs62413038
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the minor alleles of rs62413038 (OR = 1.21, 95%CI: 1.01-1.43, p = .036) and rs9450607 (OR = 1.26, 95% CI: 1.05-1.53, p = .016) were associated with an increased risk of lumbar disc herniation in the allelic model analysis.
|
31359629 |
2019 |
|
rs6265
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rs11030064 in BDNFOS gene was associated with modified susceptibility for LDH at age ≤50 years but three loci (rs6265, rs11030104 and rs10767664) of BDNF gene increased LDH risk at age >50 years.
|
30143695 |
2018 |
|
rs6651255
|
|
|
0.710 |
GeneticVariation |
BEFREE |
In light of presented findings, we speculate that the effect of rs6651255 on LDHsurg is driven by susceptibility to developing severe and persistent sciatica upon LDH.
|
28223688 |
2017 |
|
rs6651255
|
|
|
0.710 |
GeneticVariation |
GWASCAT |
In light of presented findings, we speculate that the effect of rs6651255 on LDHsurg is driven by susceptibility to developing severe and persistent sciatica upon LDH.
|
28223688 |
2017 |