|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These data suggest that both MTHFR C677T and eNOS G894T variants should be regarded as genetic risk factors for hyperhomocysteinemia in patients with cognitive decline.
|
21607713 |
2011 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Hyperhomocysteinemia, intima-media thickness and C677T MTHFR gene polymorphism: a correlation study in patients with cognitive impairment.
|
19342053 |
2009 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The current study did not find evidence of an association between the MTHFR C677T TT genotype and impaired cognition or depression in a population with adequate folate status and a high prevalence of cognitive impairment and depression.
|
22739363 |
2012 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Low folate intake and genetic variants in folate metabolism, such as the methylenetetrahydrofolate reductase (MTHFR) 677 C>T polymorphism, have been suggested to impact brain function and increase the risk for cognitive decline and late-onset Alzheimer's disease.
|
30288696 |
2019 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To elucidate the specific role of the TT genotype of MTHFR in the development of cerebral infarction with and without cognitive impairment, we determined the prevalence of hyperhomocyst(e)inemia and the C677T genotypes of MTHFR in 143 patients with vascular dementia, 122 patients with cerebral infarction, and 217 healthy subjects matched for age and sex.
|
10938012 |
2000 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Apolipoprotein E epsilon-4 (APOE ε4) allele, methylenetetrahydrofolate reductase (MTHFR C677T), and methionine synthase (MTR A2756G) were tested their associations with cognitive impairment in people with late-life depression (LLD).
|
27111719 |
2017 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Both CT genotype and T allele of MTHFR C677T gene polymorphism were found to pose significant decreased risk for CI.
|
30245375 |
2018 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Methylenetetrahydrofolate reductase 677C>T and methionine synthase 2756A>G mutations: no impact on survival, cognitive functioning, or cognitive decline in nonagenarians.
|
17339646 |
2007 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The T allele in a C677T variant in methylenetetrahydrofolate reductase (MTHFR) gene is associated with elevated plasma homocysteine, which is detrimental to vascular integrity and has been linked to cognitive decline.
|
19013496 |
2009 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although the intermediate mechanisms for C677T effects remain uncertain, these results suggest that MTHFR-related cognitive impairment and negative symptoms reflect differing neural substrates.
|
17344026 |
2007 |
|
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We designed this study to determine if tHcy is causally related to cognitive impairment in later life by investigating its association with high tHcy and the MTHFR-C677T polymorphism.
|
21358708 |
2012 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The BDNF Val66Met polymorphism, resting-state hippocampal functional connectivity and cognitive deficits in acute late-onset depression.
|
26000753 |
2015 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results do not support that the common genetic risk variants in rs6265 and rs1006737 are associated with cognitive dysfunction.
|
27221213 |
2016 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings supported the hypothesis that the BDNF Val66Met polymorphism may affect susceptibility to regional WMH volume and such genotype-by-WMH interaction effect is correlated with cognitive decline in non-demented elderly males, in which the Met allele plays a protective role.
|
24275008 |
2014 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our analyses suggested the G196A (Val66Met) polymorphism was significantly associated with cog</span>nitive impairment in PD, especially in Caucasian populations.
|
31365694 |
2019 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This article reviews the current literature available regarding associations between the Val66Met polymorphism, childhood trauma and cognitive dysfunction in schizophrenia.
|
26603624 |
2016 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Brain-derived neurotrophic factor genetic polymorphism (rs6265) is protective against chemotherapy-associated cognitive impairment in patients with early-stage breast cancer.
|
26289590 |
2016 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BDNF G196A (Val66Met) polymorphism associated with cognitive impairment in Parkinson's disease.
|
24394906 |
2014 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We examined whether BDNF Val66Met variation was associated with cognitive impairment in mTLE.
|
29952080 |
2019 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Several heritability studies have reported that the Brain Derived Neurotrophic Factor (<i>BDNF</i>) Val66Met genetic polymorphism could contribute to the acceleration of cognitive decline in aging.
|
30333719 |
2018 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis implicates Val66Met BDNF polymorphism may be associated with Parkinson's disease cognitive impairment, further well-designed studies with larger populations are required to validate these results owing to the limited research.
|
31104169 |
2019 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Met66 allele of the functional Val66Met polymorphism in the brain-derived neurotrophic factor gene confers protection against neurocognitive dysfunction in systemic lupus erythematosus.
|
16606648 |
2006 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Functional rs6265 polymorphism in the brain-derived neurotrophic factor gene confers protection against neurocognitive dysfunction in posttraumatic stress disorder among Chinese patients with hepatocellular carcinoma.
|
30659644 |
2019 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
BDNF Val66Met polymorphism is associated with cognitive impairment in Italian patients with Parkinson's disease.
|
19538209 |
2009 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To characterize the neurocognitive and brain morphometric phenotypic correlates of the BDNF Val66Met polymorphism and to test the specificity of the BDNF(Met) variant on cognitive dysfunction in schizophrenia.
|
16818862 |
2006 |