rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Carriage of BDNF Val66Met has been associated with faster cognitive decline and greater hippocampal atrophy in cognitively normal elderly.
|
31771052 |
2020 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Carriage of BDNF Val66Met has been associated with faster cognitive decline and greater hippocampal atrophy in cognitively normal elderly.
|
31771052 |
2020 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Low folate intake and genetic variants in folate metabolism, such as the methylenetetrahydrofolate reductase (MTHFR) 677 C>T polymorphism, have been suggested to impact brain function and increase the risk for cognitive decline and late-onset Alzheimer's disease.
|
30288696 |
2019 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our analyses suggested the G196A (Val66Met) polymorphism was significantly associated with cog</span>nitive impairment in PD, especially in Caucasian populations.
|
31365694 |
2019 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We examined whether BDNF Val66Met variation was associated with cognitive impairment in mTLE.
|
29952080 |
2019 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis implicates Val66Met BDNF polymorphism may be associated with Parkinson's disease cognitive impairment, further well-designed studies with larger populations are required to validate these results owing to the limited research.
|
31104169 |
2019 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Functional rs6265 polymorphism in the brain-derived neurotrophic factor gene confers protection against neurocognitive dysfunction in posttraumatic stress disorder among Chinese patients with hepatocellular carcinoma.
|
30659644 |
2019 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Replication and Meta-analysis of the Association between BDNF Val66Met Polymorphism and Cognitive Impairment in Patients Receiving Chemotherapy.
|
30382534 |
2019 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
While the BDNF polymorphism (rs6265) is associated with faster cognitive decline and increased hippocampal atrophy, a replicable genetic association of BDNF with AD risk has yet to be demonstrated.
|
30909233 |
2019 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A total of 1,081 adults without dementia (375 healthy subjects and 706 individuals with mild cognitive impairment) were recruited from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to test the influence of BDNF Val66Met polymorphism on cognitive impairment, brain structure atrophy, and change in the levels of CSF biomarkers.
|
30775992 |
2019 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The association between higher BDNF levels and cognitive impairment, mainly attention in smokers appears to be dependent on the BDNF Val66Met polymorphism.
|
30659208 |
2019 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Replication and Meta-analysis of the Association between BDNF Val66Met Polymorphism and Cognitive Impairment in Patients Receiving Chemotherapy.
|
30382534 |
2019 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We examined whether BDNF Val66Met variation was associated with cognitive impairment in mTLE.
|
29952080 |
2019 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our analyses suggested the G196A (Val66Met) polymorphism was significantly associated with cog</span>nitive impairment in PD, especially in Caucasian populations.
|
31365694 |
2019 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis implicates Val66Met BDNF polymorphism may be associated with Parkinson's disease cognitive impairment, further well-designed studies with larger populations are required to validate these results owing to the limited research.
|
31104169 |
2019 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A total of 1,081 adults without dementia (375 healthy subjects and 706 individuals with mild cognitive impairment) were recruited from the Alzheimer's Disease Neuroimaging Initiative (ADNI) to test the influence of BDNF Val66Met polymorphism on cognitive impairment, brain structure atrophy, and change in the levels of CSF biomarkers.
|
30775992 |
2019 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The association between higher BDNF levels and cognitive impairment, mainly attention in smokers appears to be dependent on the BDNF Val66Met polymorphism.
|
30659208 |
2019 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Both CT genotype and T allele of MTHFR C677T gene polymorphism were found to pose significant decreased risk for CI.
|
30245375 |
2018 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Several heritability studies have reported that the Brain Derived Neurotrophic Factor (<i>BDNF</i>) Val66Met genetic polymorphism could contribute to the acceleration of cognitive decline in aging.
|
30333719 |
2018 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
<i>BDNF</i> gene Val66Met variation may be associated with cognitive deficits in T2DM, especially with delayed memory.
|
29423073 |
2018 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Several heritability studies have reported that the Brain Derived Neurotrophic Factor (<i>BDNF</i>) Val66Met genetic polymorphism could contribute to the acceleration of cognitive decline in aging.
|
30333719 |
2018 |
rs759834365
|
|
|
0.100 |
GeneticVariation |
BEFREE |
<i>BDNF</i> gene Val66Met variation may be associated with cognitive deficits in T2DM, especially with delayed memory.
|
29423073 |
2018 |
rs1217691063
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Apolipoprotein E epsilon-4 (APOE ε4) allele, methylenetetrahydrofolate reductase (MTHFR C677T), and methionine synthase (MTR A2756G) were tested their associations with cognitive impairment in people with late-life depression (LLD).
|
27111719 |
2017 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that the <i>BDNF</i> Val66Met polymorphism may play an important role in cognitive decline and could be considered as a target for novel AD therapeutics.
|
28468845 |
2017 |
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results support the hypothesis of the BDNF Val66Met polymorphism as a risk factor associated with cognitive impairment, corroborating previous findings in young and older adults.
|
28099630 |
2017 |