Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6265
rs6265
0.030 GeneticVariation BEFREE The BDNF Val66Met polymorphism alters susceptibility to depression, anxiety, and insomnia by altering availability and expression of BDNF in brain and blood. 31782101

2020

dbSNP: rs759834365
rs759834365
0.030 GeneticVariation BEFREE The BDNF Val66Met polymorphism alters susceptibility to depression, anxiety, and insomnia by altering availability and expression of BDNF in brain and blood. 31782101

2020

dbSNP: rs4680
rs4680
0.030 GeneticVariation BEFREE The Val158Met rs4680 polymorphism does not appear to be involved in predisposition to suffer from migraine; however, this genetic factor may be involved in the phenotypic expression of chronic migraine, as anxiety, depression, and widespread pressure pain sensitivity were greater in those women with chronic, but not episodic, migraine with the Met/Met genotype. 30481348

2019

dbSNP: rs6265
rs6265
0.030 GeneticVariation BEFREE Ninety-five PCa patients completed psychological inventories for anxiety, depression, and psychological resilience (PR) and also gave a saliva sample for cortisol and a mouthwash sample for genetic testing for the presence of the BDNF Val66Met polymorphism. 29603029

2018

dbSNP: rs759834365
rs759834365
0.030 GeneticVariation BEFREE Ninety-five PCa patients completed psychological inventories for anxiety, depression, and psychological resilience (PR) and also gave a saliva sample for cortisol and a mouthwash sample for genetic testing for the presence of the BDNF Val66Met polymorphism. 29603029

2018

dbSNP: rs4680
rs4680
0.030 GeneticVariation BEFREE Catechol-O-methyltransferase Val158Met polymorphism influences anxiety, depression, and disability, but not pressure pain sensitivity, in women with fibromyalgia syndrome. 23025981

2012

dbSNP: rs4680
rs4680
0.030 GeneticVariation BEFREE We investigated the associations between COMT Val(158)Met and depression in a Swedish population-based sample of 405 depressed individuals (major depression diagnosis, dysthymia or mixed anxiety depression defined according to DSM-IV) and 2,151 healthy controls. 20828831

2011

dbSNP: rs6265
rs6265
0.030 GeneticVariation BEFREE This study sample is relatively large but our results do not support an association between BDNF Val66Met and anxiety, depression, or neuroticisim. 18797396

2008

dbSNP: rs759834365
rs759834365
0.030 GeneticVariation BEFREE This study sample is relatively large but our results do not support an association between BDNF Val66Met and anxiety, depression, or neuroticisim. 18797396

2008

dbSNP: rs1799971
rs1799971
0.010 GeneticVariation BEFREE From the neuroendocrine system, OPRM1 rs1799971 correlated increasing levels of female's Anxiety, depression and Social Dysfunction scores. 30656852

2019

dbSNP: rs17689918
rs17689918
0.010 GeneticVariation BEFREE We assess the effects of CRHR1 variant (rs17689918)-by-environment interactions on emotionality and behavioral traits, including anxiety, depression, aggression and antisocial behaviors. 29772307

2018

dbSNP: rs34637584
rs34637584
0.010 GeneticVariation BEFREE In the present study, we examined anxiety/depression-like behaviors and accompanying neurochemical changes in differently aged transgenic (Tg) mice expressing human mutant LRRK2 G2019S. 29305532

2018

dbSNP: rs1051730
rs1051730
0.010 GeneticVariation BEFREE Mendelian randomisation meta-analyses using a genetic variant (rs16969968/rs1051730) as a proxy for smoking heaviness, and observational meta-analyses of the associations of smoking status and smoking heaviness with depression, anxiety and psychological distress. 25293386

2014

dbSNP: rs16969968
rs16969968
0.010 GeneticVariation BEFREE Mendelian randomisation meta-analyses using a genetic variant (rs16969968/rs1051730) as a proxy for smoking heaviness, and observational meta-analyses of the associations of smoking status and smoking heaviness with depression, anxiety and psychological distress. 25293386

2014

dbSNP: rs138060
rs138060
0.010 GeneticVariation BEFREE The major findings were: 1) patients heterozygous (T/G) for rs138060 had significantly worse Brief Psychiatric Rating Scale (BPRS) Total and anxiety/depression sub-scale scores, and higher Scale for the Assessment of Positive Symptoms (SAPS) Total scores than G/G homozygous patients; and 2) patients heterozygous (A/G) for rs138097 demonstrated significantly worse performance on neuropsychological testing, specifically on tests of executive function and working memory, compared to patients homozygous for the G and A alleles. 18823757

2008

dbSNP: rs138097
rs138097
0.010 GeneticVariation BEFREE The major findings were: 1) patients heterozygous (T/G) for rs138060 had significantly worse Brief Psychiatric Rating Scale (BPRS) Total and anxiety/depression sub-scale scores, and higher Scale for the Assessment of Positive Symptoms (SAPS) Total scores than G/G homozygous patients; and 2) patients heterozygous (A/G) for rs138097 demonstrated significantly worse performance on neuropsychological testing, specifically on tests of executive function and working memory, compared to patients homozygous for the G and A alleles. 18823757

2008

dbSNP: rs2478813
rs2478813
0.010 GeneticVariation BEFREE There was evidence of an allelic association between rs2478813 (and other single nucleotide polymorphisms correlated with it) and anxiety, depression, neuroticism, and psychological distress; the association with anxiety is significant after Bonferroni correction for multiple testing (empirical P<.001). 17339520

2007

dbSNP: rs716461
rs716461
0.010 GeneticVariation BEFREE To perform a genetic association study between 6 single nucleotide polymorphisms from the PLXNA2 gene (rs3736963, rs2767565, rs752016, rs1327175, rs2478813, and rs716461) and anxiety, depression, neuroticism, and psychological distress. 17339520

2007

dbSNP: rs1805054
rs1805054
0.010 GeneticVariation BEFREE Compared to patients with the T/C 267 genotype, those with T/T 267 showed less severe positive symptoms (p=0.006) and general psychopathology (including anxiety, depression, and cognitive dysfunctions) (p=0.005). 14741325

2004