|
rs12132140
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The lead signals interacting with smoking were rs12132140 (AP = 0.56, 95% CI = 0.22-0.90), p = 1.28e-03) in FCRL1 for LS and rs61780312 (AP = 0.62, 95% CI = 0.28-0.90), p = 3e-04) in IL23R for non-LS.
|
31819081 |
2019 |
|
rs61780312
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The lead signals interacting with smoking were rs12132140 (AP = 0.56, 95% CI = 0.22-0.90), p = 1.28e-03) in FCRL1 for LS and rs61780312 (AP = 0.62, 95% CI = 0.28-0.90), p = 3e-04) in IL23R for non-LS.
|
31819081 |
2019 |
|
rs3129843
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a joint analysis, seven SNPs were associated with non-Löfgren sarcoidosis (NL; the strongest association with rs3177928, <i>P</i> = 1.79E-07, OR = 1.9) and eight with Löfgren's syndrome [Löfgren syndrome (LS); the strongest association with rs3129843, <i>P</i> = 3.44E-12, OR = 3.4] when compared with healthy controls (<i>n</i> = 870).
|
28469621 |
2017 |
|
rs3135365
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When the SNPs and <i>HLA-DRB1</i> alleles were analyzed together, independent association was observed for four SNPs in the <i>HLA-DRA/BTNL2</i> region: rs3135365 (NL; <i>P</i> = 0.015), rs3177928 (NL; <i>P</i> < 0.001), rs6937545 (LS; <i>P</i> = 0.012), and rs5007259 (disease activity; <i>P</i> = 0.002).
|
28469621 |
2017 |
|
rs3177928
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When the SNPs and <i>HLA-DRB1</i> alleles were analyzed together, independent association was observed for four SNPs in the <i>HLA-DRA/BTNL2</i> region: rs3135365 (NL; <i>P</i> = 0.015), rs3177928 (NL; <i>P</i> < 0.001), rs6937545 (LS; <i>P</i> = 0.012), and rs5007259 (disease activity; <i>P</i> = 0.002).
|
28469621 |
2017 |
|
rs5007259
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When the SNPs and <i>HLA-DRB1</i> alleles were analyzed together, independent association was observed for four SNPs in the <i>HLA-DRA/BTNL2</i> region: rs3135365 (NL; <i>P</i> = 0.015), rs3177928 (NL; <i>P</i> < 0.001), rs6937545 (LS; <i>P</i> = 0.012), and rs5007259 (disease activity; <i>P</i> = 0.002).
|
28469621 |
2017 |
|
rs6937545
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When the SNPs and <i>HLA-DRB1</i> alleles were analyzed together, independent association was observed for four SNPs in the <i>HLA-DRA/BTNL2</i> region: rs3135365 (NL; <i>P</i> = 0.015), rs3177928 (NL; <i>P</i> < 0.001), rs6937545 (LS; <i>P</i> = 0.012), and rs5007259 (disease activity; <i>P</i> = 0.002).
|
28469621 |
2017 |
|
rs755622
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 171 patients with Löfgren's syndrome and 313 controls were genotyped for a single nucleotide polymorphism at position -173 of the MIF gene (SNP rs755622), using a PCR and a restriction enzyme technique.
|
24951298 |
2014 |
|
rs206530
|
|
|
0.010 |
GeneticVariation |
BEFREE |
BTNL2 rs206530 A allele frequencies were significantly higher in sarcoidosis with no linkage disequilibrium with HLA-DRB1 alleles, except in the subgroup of patients with Löfgren syndrome where the determinant allele was HLA-DRB1*03.
|
23017494 |
2012 |
|
rs2076530
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found independent genetic risk factors in clinically distinct disease phenotypes: BTNL2 rs2076530 A allele in patients without Löfgren syndrome or with isolated thoracic disease, and HLA-DRB1*03 in Löfgren syndrome or disease resolution.
|
23017494 |
2012 |
|
rs1891467
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs in TGF-β2 (rs1891467) and TGF-β3 (rs3917200) were investigated in 296 patients with sarcoidosis (acute/self remitting, n = 70 (including 62 patients with Löfgren's syndrome); chronic, n = 168; acute/chronic, n = 58) by real-time PCR.
|
21148227 |
2011 |
|
rs3917200
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs in TGF-β2 (rs1891467) and TGF-β3 (rs3917200) were investigated in 296 patients with sarcoidosis (acute/self remitting, n = 70 (including 62 patients with Löfgren's syndrome); chronic, n = 168; acute/chronic, n = 58) by real-time PCR.
|
21148227 |
2011 |
|
rs3087456
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correction for multiple testing, our data showed a significant association with Löfgren's syndrome in allelic model for the rs3087456 SNP, which was not detected in non-Löfgren's patients.
|
20230522 |
2010 |