|
rs698
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Based on the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, we studied the association of polymorphisms in the tobacco carcinogen-metabolizing gene CYP2A13 (Arg101Stop) and the alcohol-metabolizing genes ADH1B (Arg48His) and ADH1C (Ile350Val) with pancreatic cancer risk.
|
19812523 |
2010 |
|
rs6475609
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Bioinformatics analysis revealed rs1537373 lies in the linkage disequilibrium (LD) block which the rs6475609 tagged might have potential function and was also associated with a decreased risk of PC in both stages (OR = 0.82, 95% CI = 0.75-0.90 in combined analysis).
|
30604909 |
2019 |
|
rs1042522
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Carriers of the variant C allele of rs1042522 polymorphism were at an increased risk of pancreatic cancer [odds ratio (OR) 1.73; 95% confidence interval (CI) 1.26-2.39; P = 0.001].
|
20110284 |
2010 |
|
rs1045485
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CASP8 rs1045485 [odds ratio (OR), 0.78; 95% confidence interval (95% CI), 0.65-0.9; P = 0.005] and MAP3K1 rs889312 (OR, 0.85; 95% CI, 0.74-0.97; P = 0.017) showed evidence of association with risk of pancreatic cancer.
|
19843670 |
2009 |
|
rs889312
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CASP8 rs1045485 [odds ratio (OR), 0.78; 95% confidence interval (95% CI), 0.65-0.9; P = 0.005] and MAP3K1 rs889312 (OR, 0.85; 95% CI, 0.74-0.97; P = 0.017) showed evidence of association with risk of pancreatic cancer.
|
19843670 |
2009 |
|
rs505922
|
|
|
0.740 |
GeneticVariation |
BEFREE |
Consistent with earlier reports showing a higher risk of PC for individuals with the non-O blood type, the previously reported protective allele (T) for rs505922 was found to be strongly correlated (r(2) = 0.96) with the O allele.
|
21306478 |
2011 |
|
rs1800843
|
|
|
0.010 |
GeneticVariation |
BEFREE |
DNA from 931 patients with pancreatic cancer was evaluated for the SNP (C > A; rs1800843) in the CCK-BR gene.
|
25469546 |
2015 |
|
rs1458766475
|
|
|
0.010 |
GeneticVariation |
BEFREE |
E-selectin S128R "C" allele may confer an increased susceptibility to pancreatic cancer development, while its carriage status does not appear to be related to the aggressive features of this malignancy.
|
20607758 |
2010 |
|
rs5361
|
|
|
0.010 |
GeneticVariation |
BEFREE |
E-selectin S128R "C" allele may confer an increased susceptibility to pancreatic cancer development, while its carriage status does not appear to be related to the aggressive features of this malignancy.
|
20607758 |
2010 |
|
rs587778883
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, gemcitabine treatment of control animals and p48-Cre/LSL-Kras(G12D) animals with pancreatic cancer caused distinct and up to 60-fold changes in circulating miRs that indicate differential drug effects on normal and cancer tissues.
|
21738581 |
2011 |
|
rs757748401
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, preclinical experiments suggest that targeting the NFATc2-STAT3-GSK-3β module inhibits proliferation and tumor growth and interferes with inflammation-induced pancreatic cancer progression in Kras(G12D) mice.
|
26823495 |
2016 |
|
rs397507444
|
|
|
0.050 |
GeneticVariation |
BEFREE |
First, we performed a case-control study of germline MTHFR polymorphisms (C677T, A1298C) in 303 patients with pancreatic cancer and 305 matched control subjects.
|
16234003 |
2005 |
|
rs3021088
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five common variants were associated with pancreatic cancer at nominal statistical significance (P < 0.05) with the strongest finding for mt5460g in the ND2 gene [OR = 3.9; 95% confidence interval (CI), 1.5-10; P = 0.004] which encodes an A331T substitution.
|
22174369 |
2012 |
|
rs10741657
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For example, pancreas cancer risk was inversely associated with CYP2R1 rs10741657 (AA versus GG, OR = 0.70; 95%CI: 0.51-0.95) and positively with CYP24A1 rs6127119 (TT versus CC.OR = 1.94; 95%CI: 1.28-2.94).
|
23826131 |
2013 |
|
rs6127119
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For example, pancreas cancer risk was inversely associated with CYP2R1 rs10741657 (AA versus GG, OR = 0.70; 95%CI: 0.51-0.95) and positively with CYP24A1 rs6127119 (TT versus CC.OR = 1.94; 95%CI: 1.28-2.94).
|
23826131 |
2013 |
|
rs786204195
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, the germline P48T mutation was found in the CDKN2A gene exon 1, which is known to be associated with melanoma and pancreatic cancer.
|
18299477 |
2008 |
|
rs4988483
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, the SSTR5 L48M AC variant and smoking had a joint effect on pancreatic cancer risk (p(interaction) = 0.035).
|
21692047 |
2011 |
|
rs1153280
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations.
|
22158540 |
2011 |
|
rs1153287
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations.
|
22158540 |
2011 |
|
rs1153294
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations.
|
22158540 |
2011 |
|
rs117214
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations.
|
22158540 |
2011 |
|
rs12413624
|
|
T |
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations.
|
22158540 |
2011 |
|
rs1547374
|
|
A |
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations.
|
22158540 |
2011 |
|
rs2027605
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations.
|
22158540 |
2011 |
|
rs2035565
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations.
|
22158540 |
2011 |