|
rs1800566
|
|
|
0.010 |
GeneticVariation |
BEFREE |
According to the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, an association of functional polymorphisms in oxidative stress-modifying genes superoxide dismutase 2 (SOD2 [Ala16Val, rs4880]), SOD3 (Arg231Gly, rs1799895), nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase (NQO1 [Pro187Ser, rs1800566], and NQO2 (Phe47Leu, rs1143684) with pancreatic cancer risk was studied.
|
20966810 |
2011 |
|
rs779731636
|
|
|
0.010 |
GeneticVariation |
BEFREE |
According to the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, an association of functional polymorphisms in oxidative stress-modifying genes superoxide dismutase 2 (SOD2 [Ala16Val, rs4880]), SOD3 (Arg231Gly, rs1799895), nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase (NQO1 [Pro187Ser, rs1800566], and NQO2 (Phe47Leu, rs1143684) with pancreatic cancer risk was studied.
|
20966810 |
2011 |
|
rs2308321
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Adjusting for multiple comparisons, MGMT I143V AG/GG, PMS2 IVS1-1121C > T TC/TT, and PMS2L3 Ex1 + 118C > T CT/TT genotypes showed significant main effects on pancreatic cancer risk at FDR <1% with OR (95% CI) of 0.60 (0.46-0.80), 1.44 (1.14-1.81), and 5.54 (2.10-14.61), respectively (P ≤ 0.0015).
|
21681824 |
2012 |
|
rs1448106115
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Adjusting for multiple comparisons, MGMT I143V AG/GG, PMS2 IVS1-1121C > T TC/TT, and PMS2L3 Ex1 + 118C > T CT/TT genotypes showed significant main effects on pancreatic cancer risk at FDR <1% with OR (95% CI) of 0.60 (0.46-0.80), 1.44 (1.14-1.81), and 5.54 (2.10-14.61), respectively (P ≤ 0.0015).
|
21681824 |
2012 |
|
rs876661110
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Adjusting for multiple comparisons, MGMT I143V AG/GG, PMS2 IVS1-1121C > T TC/TT, and PMS2L3 Ex1 + 118C > T CT/TT genotypes showed significant main effects on pancreatic cancer risk at FDR <1% with OR (95% CI) of 0.60 (0.46-0.80), 1.44 (1.14-1.81), and 5.54 (2.10-14.61), respectively (P ≤ 0.0015).
|
21681824 |
2012 |
|
rs935821839
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Adjusting for multiple comparisons, MGMT I143V AG/GG, PMS2 IVS1-1121C > T TC/TT, and PMS2L3 Ex1 + 118C > T CT/TT genotypes showed significant main effects on pancreatic cancer risk at FDR <1% with OR (95% CI) of 0.60 (0.46-0.80), 1.44 (1.14-1.81), and 5.54 (2.10-14.61), respectively (P ≤ 0.0015).
|
21681824 |
2012 |
|
rs141095230
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Adjusting for multiple comparisons, MGMT I143V AG/GG, PMS2 IVS1-1121C > T TC/TT, and PMS2L3 Ex1 + 118C > T CT/TT genotypes showed significant main effects on pancreatic cancer risk at FDR <1% with OR (95% CI) of 0.60 (0.46-0.80), 1.44 (1.14-1.81), and 5.54 (2.10-14.61), respectively (P ≤ 0.0015).
|
21681824 |
2012 |
|
rs949647240
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Adjusting for multiple comparisons, MGMT I143V AG/GG, PMS2 IVS1-1121C > T TC/TT, and PMS2L3 Ex1 + 118C > T CT/TT genotypes showed significant main effects on pancreatic cancer risk at FDR <1% with OR (95% CI) of 0.60 (0.46-0.80), 1.44 (1.14-1.81), and 5.54 (2.10-14.61), respectively (P ≤ 0.0015).
|
21681824 |
2012 |
|
rs121434592
|
|
|
0.010 |
GeneticVariation |
BEFREE |
AKT1 (E17K) mutation in pancreatic cancer.
|
18783292 |
2008 |
|
rs1056836
|
|
|
0.010 |
GeneticVariation |
BEFREE |
All patients were followed to determine their treatment and overall survival.<br />Carriers of rare genotype Val/Val in codon 432 of CYP1B1 (rs1056836) were under significantly lower risk of pancreatic cancer than wild type carriers (p=0.035).
|
19895167 |
2010 |
|
rs1042821
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the MSH6 G39E polymorphism is considered to be a biomarker of hereditary nonpolyposis colorectal cancer (HNPCC), many studies have also found that it may be associated with increased risks of lung, breast, and pancreatic cancers, with inconsistent estimated risks.
|
24622885 |
2014 |
|
rs121913527
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among fish injected with one of five KRAS mutations reported in other tumor types but not in human pancreatic cancer, 2/79 (2.5%) developed pancreatic tumors, with both tumors arising in fish injected with A146T.
|
25065594 |
2015 |
|
rs9939609
|
|
|
0.030 |
GeneticVariation |
BEFREE |
An unconditional logistic model was used to estimate the odds ratio (OR) and 95% confidence interval (CI) for the association between rs9939609 and pancreatic cancer risk.
|
23835106 |
2013 |
|
rs1801272
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Analysis of 22 selected SNPs in oxidative stress and DNA damage genes revealed that CYP2A6 L160H was associated with pancreatic cancer.
|
24651674 |
2014 |
|
rs5757573
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As a result, we identified two potential susceptibility loci (rs5757573 and rs6001516) of PDGFB associated with PC risk [odds ratio (OR) = 1.10, 95% confidence interval (CI) = 1.05-1.16, and p = 4.70 × 10<sup>-5</sup> for the rs5757573 C allele and 1.21, 1.11-1.32, and 2.01 × 10<sup>-5</sup> for the rs6001516 T allele].
|
29168174 |
2018 |
|
rs6001516
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As a result, we identified two potential susceptibility loci (rs5757573 and rs6001516) of PDGFB associated with PC risk [odds ratio (OR) = 1.10, 95% confidence interval (CI) = 1.05-1.16, and p = 4.70 × 10<sup>-5</sup> for the rs5757573 C allele and 1.21, 1.11-1.32, and 2.01 × 10<sup>-5</sup> for the rs6001516 T allele].
|
29168174 |
2018 |
|
rs104894094
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As compared with the general population, the risk of pancreatic cancer (PC) was increased 9.4-fold [95% confidence interval (CI) 2.7-33.4] and 2.2-fold (95% CI 0.8-5.7) in G101W-positive and -negative MF, respectively, while mean ages at onset were 61 and 77 years, respectively.
|
14679123 |
2004 |
|
rs1276300653
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As for c.627T>C, statistically significant decreased PC susceptibility was detected in CC genotype compared to TT wild genotype (OR = 0.57, 95% CI 0.35-0.94, P = 0.028).
|
23999824 |
2014 |
|
rs145574072
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As for c.627T>C, statistically significant decreased PC susceptibility was detected in CC genotype compared to TT wild genotype (OR = 0.57, 95% CI 0.35-0.94, P = 0.028).
|
23999824 |
2014 |
|
rs138147246
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As for c.828A>G SNP, the significantly decreased risk of pancreatic cancer was detected (G vs. A: OR 0.74, 95 % CI 0.59-0.92, P = 0.006).
|
24935623 |
2014 |
|
rs9904341
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association between rs9904341 G<C gene polymorphism and susceptibility to pancreatic cancer in a Chinese population.
|
26125713 |
2015 |
|
rs13181
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Association between ERCC2 Lys751Gln polymorphism and the risk of pancreatic cancer, especially among Asians: evidence from a meta-analysis.
|
28223548 |
2017 |
|
rs72552266
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Based on the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, we studied the association of polymorphisms in the tobacco carcinogen-metabolizing gene CYP2A13 (Arg101Stop) and the alcohol-metabolizing genes ADH1B (Arg48His) and ADH1C (Ile350Val) with pancreatic cancer risk.
|
19812523 |
2010 |
|
rs1229984
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Based on the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, we studied the association of polymorphisms in the tobacco carcinogen-metabolizing gene CYP2A13 (Arg101Stop) and the alcohol-metabolizing genes ADH1B (Arg48His) and ADH1C (Ile350Val) with pancreatic cancer risk.
|
19812523 |
2010 |
|
rs35385902
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Based on the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, we studied the association of polymorphisms in the tobacco carcinogen-metabolizing gene CYP2A13 (Arg101Stop) and the alcohol-metabolizing genes ADH1B (Arg48His) and ADH1C (Ile350Val) with pancreatic cancer risk.
|
19812523 |
2010 |