Source: BEFREE ×
Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.090 | GeneticVariation | BEFREE | The aim of this study was to investigate the possible role of polymorphisms of TLR4, Asp299Gly and Thr399Ile and CD14, C-159T and C-550T in the development of RSV bronchiolitis. | 25572736 | 2015 |
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0.090 | GeneticVariation | BEFREE | The TLR4 (Asp299Gly), TLR4 (Thr399Ile), and JUN (c.750G/A) SNPs showed no significant association with RSV disease. | 21837802 | 2011 |
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0.090 | GeneticVariation | BEFREE | The aim was to study the association between the TLR4 Asp299Gly polymorphism and the susceptibility to severe RSV bronchiolitis in infants. | 20575099 | 2010 |
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0.090 | GeneticVariation | BEFREE | TLR4 Asp299Gly and Thr399Ile polymorphisms: no impact on human immune responsiveness to LPS or respiratory syncytial virus. | 20711470 | 2010 |
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0.090 | GeneticVariation | BEFREE | Both SNPs were highly associated with symptomatic RSV disease in this largely premature population (p < 0.0001), with 89.5% and 87.6% of cases being heterozygous for Asp299Gly and Thr399Ile polymorphisms versus published control frequencies of 10.5% and 6.5%, respectively. | 17709532 | 2007 |
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0.090 | GeneticVariation | BEFREE | By genotyping 236 children with RSV infection and 219 healthy controls we found no association between the risk of severe RSV infection and Asp299Gly polymorphisms (P>0.05), and we demonstrate that the TLR4 Asp299Gly genotype does not influence susceptibility to either RSV serotype A or B (P>0.05). | 17449325 | 2007 |
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0.090 | GeneticVariation | BEFREE | We genotyped the CD14 promotor polymorphism -C159T and the two common TLR4 amino acid variants (D259G, and T359I) in 131 infants with severe RSV associated diseases and 270 controls. | 17264400 | 2006 |
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0.090 | GeneticVariation | BEFREE | The presence of TLR4 mutations (Asp299Gly and Thr399Ile) were associated with severe RSV bronchiolitis and were significantly over-represented in groups II and III. | 16542364 | 2006 |
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0.090 | GeneticVariation | BEFREE | The association of the TLR4 mutations (Asp299Gly and Thr399Ile) and the CD14/-159 polymorphism were analyzed in 99 infants hospitalized with severe RSV bronchiolitis (group I). | 15143473 | 2004 |
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0.070 | GeneticVariation | BEFREE | The aim of this study was to investigate the possible role of polymorphisms of TLR4, Asp299Gly and Thr399Ile and CD14, C-159T and C-550T in the development of RSV bronchiolitis. | 25572736 | 2015 |
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0.070 | GeneticVariation | BEFREE | The TLR4 (Asp299Gly), TLR4 (Thr399Ile), and JUN (c.750G/A) SNPs showed no significant association with RSV disease. | 21837802 | 2011 |
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0.070 | GeneticVariation | BEFREE | TLR4 Asp299Gly and Thr399Ile polymorphisms: no impact on human immune responsiveness to LPS or respiratory syncytial virus. | 20711470 | 2010 |
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0.070 | GeneticVariation | BEFREE | Both SNPs were highly associated with symptomatic RSV disease in this largely premature population (p < 0.0001), with 89.5% and 87.6% of cases being heterozygous for Asp299Gly and Thr399Ile polymorphisms versus published control frequencies of 10.5% and 6.5%, respectively. | 17709532 | 2007 |
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0.070 | GeneticVariation | BEFREE | The presence of TLR4 mutations (Asp299Gly and Thr399Ile) were associated with severe RSV bronchiolitis and were significantly over-represented in groups II and III. | 16542364 | 2006 |
||||
|
0.070 | GeneticVariation | BEFREE | We genotyped the CD14 promotor polymorphism -C159T and the two common TLR4 amino acid variants (D259G, and T359I) in 131 infants with severe RSV associated diseases and 270 controls. | 17264400 | 2006 |
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0.070 | GeneticVariation | BEFREE | The association of the TLR4 mutations (Asp299Gly and Thr399Ile) and the CD14/-159 polymorphism were analyzed in 99 infants hospitalized with severe RSV bronchiolitis (group I). | 15143473 | 2004 |
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0.010 | GeneticVariation | BEFREE | We show that infection of polarized Calu3 respiratory cells with recombinant RSV having point mutations in Cys173 and 176 (C173/176S) (rA2-GC12), or Cys186 (C186S) (rA2-GC4) is associated with a decline in the integrity of polarized Calu-3 cultures and decreased virus production. | 28671606 | 2017 |
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0.010 | GeneticVariation | BEFREE | One of the variants was a highly functional nonsynonymous variant in ADRB2 (rs1800888), which was also nominally associated with asthma (p = 0.027) and active asthma (p = 0.013) among European Americans with severe RSV bronchiolitis without including the ESP. | 26587832 | 2015 |
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0.010 | GeneticVariation | BEFREE | The aim of this study was to investigate whether IFN-γ CA microsatellite (rs3138557) polymorphism was associated with susceptibility to RSV in Chinese Han children and with the severity of the infection. | 25130433 | 2014 |
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0.010 | GeneticVariation | BEFREE | We assessed the relationship between polymorphisms rs7041 and rs4588, which define haplotypes GC1s, GC1f, and GC2, and RSV bronchiolitis susceptibility and subsequent asthma. | 24447085 | 2014 |
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0.010 | GeneticVariation | BEFREE | The rs7041_C allele was also more frequent in the RSV bronchiolitis group compared with controls (OR 1.12, 95% CI 1.02, 1.4, P = 0.03) in the Netherlands, especially in mechanically ventilated patients (P = 0.009). | 24447085 | 2014 |
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0.010 | GeneticVariation | BEFREE | In our human study, the A118G single nucleotide polymorphism rs1799971 was associated with respiratory syncytial virus disease severity (p = 0.015). | 23222260 | 2013 |
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0.010 | GeneticVariation | BEFREE | The TLR1 variant (rs4543123) was associated with both multiple viruses (respiratory syncytial virus and parainfluenza virus) and multiple phenotypes. | 23063165 | 2012 |
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0.010 | GeneticVariation | BEFREE | Haplotype analysis of two SNPs in the IL-9 gene (rs2069885 and rs1799962) showed overrepresentation of the TT haplotype in girls with severe RSV bronchiolitis requiring hospitalization indicating that this is the haplotype conferring the highest risk in girls. | 20503287 | 2010 |
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0.010 | GeneticVariation | BEFREE | Haplotype analysis of two SNPs in the IL-9 gene (rs2069</span>885 and rs1799962) showed overrepresentation of the TT haplotype in girls with severe RSV bronchiolitis requiring hospitalization indicating that this is the haplotype conferring the highest risk in girls. | 20503287 | 2010 |