rs16901979
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In particular, both homozygous AA and heterozygous CA genotypes of rs16901979, as well as the AA and CA genotypes of rs1447295, were associated with the risk of prostate cancer.
|
30061842 |
2018 |
rs16901979
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Therefore, this meta-analysis demonstrated that 8q24 polymorphisms (rs6983267 T>G, rs1447295 C>A, rs16901979 C>A, rs6983561 A>C and rs10090154 C>T) were associated with the susceptibility to PCa, which held the potential biomarkers for PCa risk.
|
29158792 |
2017 |
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Therefore, this meta-analysis demonstrated that 8q24 polymorphisms (rs6983267 T>G, rs1447295 C>A, rs16901979 C>A, rs6983561 A>C and rs10090154 C>T) were associated with the susceptibility to PCa, which held the potential biomarkers for PCa risk.
|
29158792 |
2017 |
rs16901979
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Significant differences (P < 0.00185) between the two subtypes were observed for rs16901979 (8q24) and rs1859962 (17q24), which were enriched in TMPRSS2:ERG fusion-negative (OR = 0.53, P = 0.0007) and TMPRSS2:ERG fusion-positive PrCa (OR = 1.30, P = 0.0016), respectively.
|
27798103 |
2016 |
rs16901979
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In summary, the A allele at rs16901979 was associated with the risk of prostate cancer in the Caribbean population of Guadeloupe, confirming its involvement in populations of African descent.
|
25130587 |
2016 |
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Overall, though no association was observed between the rs</span>6983267 polymorphism and risk of prostate cancer, subgroup analysis according to ethnicity showed a significant association between the rs6983267 polymorphism and risk of prostate cancer among white European men [recessive model: GG vs TG + TT, OR=1.21, (95% CI: 1.03, 1.42), P=0.02].
|
27009866 |
2016 |
rs16901979
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Three 8q24 polymorphisms (rs1447295 C>A, rs16901979 C>A, and rs6983267 T>G) have been extensively investigated for their association with prostate cancer (PCa) susceptibility, yet conclusions are contradictory.
|
26159557 |
2015 |
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Three 8q24 polymorphisms (rs1447295 C>A, rs16901979 C>A, and rs6983267 T>G) have been extensively investigated for their association with prostate cancer (PCa) susceptibility, yet conclusions are contradictory.
|
26159557 |
2015 |
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Similarly, in a subgroup analysis of European and Asian descent, our results revealed that there are associations between rs6983267 T/G polymorphism and PCa susceptibility with the dominant model (GG vs GT+TT), recessive model (GG+GT vs TT), and homozygote comparison (GG vs TT).
|
26782586 |
2015 |
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
These included correlations between an intergenic CpG site at Chr8:128393157 and the prostate cancer SNP rs16902094 (ρ = -0.54; P = 9.7 × 10(-7); q = 0.002), a PRNCR1 CpG site at Chr8:128167809 and the prostate cancer SNP rs1456315 (ρ = 0.52; P = 1.4 × 10(-6); q = 0.002), and two POU5F1B CpG sites and several prostate/colorectal cancer SNPs (for Chr8:128498051 and rs6983267, ρ = 0.46; P = 2.0 × 10(-5); q = 0.01).
|
25315430 |
2014 |
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The polymorphism rs6983267 from region 3 of the chromosome 8q24 appears to be a prominent risk factor for PCa and a biomarker for cancer aggressiveness in the group of patients who presented higher levels of PSA at the time of diagnosis.
|
24224612 |
2014 |
rs6983267
|
|
G |
0.800 |
GeneticVariation |
GWASDB |
Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies.
|
24753544 |
2014 |
rs16901979
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Genome-wide testing of putative functional exonic variants in relationship with breast and prostate cancer risk in a multiethnic population.
|
23555315 |
2013 |
rs6983267
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Genome-wide testing of putative functional exonic variants in relationship with breast and prostate cancer risk in a multiethnic population.
|
23555315 |
2013 |
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Significant associations were observed for rs4430796 TT with Gleason scores of ≥ 7 (OR = 1.76, 95% CI = 1.14-2.73) and prostate-specific antigen (PSA) levels of ≥ 10 ng/ml at diagnosis (OR = 1.63, 95% CI = 1.01-2.63), as well as for rs6983267 GG with stage 3-4 CaPs (OR = 1.91, 95% CI = 1.01-3.61).
|
22561070 |
2013 |
rs16901979
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The results of the meta-analyses indicate that rs6983267, rs1447295, rs6983561, rs7837688, rs16901979, and DG8S737 are significantly associated with a higher risk for PCa for at least one race, whereas the variants rs13254738 and rs7000448 are not.
|
22382457 |
2012 |
rs16901979
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, this is the first study showing that prostate cancer risk variants, such as rs16901979, might improve outcome prediction following ADT, thus allowing identification of high-risk patients who might benefit from appropriate adjuvant therapy.
|
21445969 |
2012 |
rs16901979
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs16901979 CA genotype carriers had a higher risk of prostate cancer than the CC genotype.
|
22583965 |
2012 |
rs16901979
|
|
|
0.800 |
GeneticVariation |
BEFREE |
SNPs rs6983561, rs7008482, and rs16901979 were significantly associated with CaP risk in WAs (P < 0.03).
|
22234922 |
2012 |
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The results of the meta-analyses indicate that rs6983267, rs1447295, rs6983561, rs7837688, rs16901979, and DG8S737 are significantly associated with a higher risk for PCa for at least one race, whereas the variants rs13254738 and rs7000448 are not.
|
22382457 |
2012 |
rs16901979
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We demonstrate that trans-acting RNA molecules facilitating resistance to androgen depletion (RAD) in vitro and castration-resistant phenotype (CRP) in vivo of PC contain intergenic 8q24-locus SNP variants (rs1447295; rs16901979; rs6983267) that were recently linked with increased risk of PC.
|
22067658 |
2011 |
rs16901979
|
|
|
0.800 |
GeneticVariation |
BEFREE |
SNP rs16901979 in region 2 was associated with significantly increased risk of prostate cancer (OR = 1.41, 95% confidence interval [CI] 1.02-1.95, P = 0.04) with the risk stronger in men with early-onset prostate cancer (OR = 2.37, 95% CI 1.40-3.99, P = 0.001).
|
21557270 |
2011 |
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We demonstrate that trans-acting RNA molecules facilitating resistance to androgen depletion (RAD) in vitro and castration-resistant phenotype (CRP) in vivo of PC contain intergenic 8q24-locus SNP variants (rs1447295; rs16901979; rs6983267) that were recently linked with increased risk of PC.
|
22067658 |
2011 |
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Correlation between genotypes and biopsy outcome (positive or negative) and Gleason score (≤6 or >6) were studied by univariate and multivariable analysis. rs1447295 and rs6983267 risk variants were found to be associated with the presence of PCa in univariate analysis. rs6983267 genotype remained significantly linked to a positive biopsy (odds ratio [OR] = 1.66, 95% confidence interval [CI]: 1.06-2.59, P = 0.026) in multivariable analysis, but rs1447295 genotype did not (OR = 1.47, 95% CI: 0.89-2.43, P = 0.13).When biopsy outcome was stratified according to Gleason score, risk variants of rs1447295 were associated with aggressive disease (Gleason score ≥7) in univariate and multivariable analysis (OR = 2.05 95% CI: 1.10-3.79, P = 0.023). rs6983267 GG genotype was not related to aggressiveness.
|
21308149 |
2011 |
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
A highly significant association (odds ratio=2.84 and p-value=0.002) was found between rs6983267 and prostate cancer in the Greek population.
|
22070222 |
2011 |