|
rs4880
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Previous studies have investigated the relationship between manganese superoxide dismutase (MnSOD) Val16Ala polymorphism and prostate cancer susceptibility, but the results have remained controversial.
|
27055786 |
2016 |
|
rs4880
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among patients who underwent RT in the test cohort, there was a significant association between 3 of the 7 SOD2 SNPs and lethal prostate cancer: rs6917589 (overall P = .006), rs2758331 (P = .04) and the functional valine to alanine polymorphism in rs4880 (P = .04).
|
25662905 |
2015 |
|
rs4880
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Here, we performed integrated in vivo and in vitro protocols that analyzed the association between Ala16Val-SOD2 polymorphism and prostate cancer aggressiveness at the time of diagnosis and evaluated the effect of the imbalance on PC proliferation using the DU-145 PC cell line treated with paraquat and porphyrin.
|
26468117 |
2015 |
|
rs4880
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the present study we investigated the association of a number of polymorphic changes in antioxidant system genes (SNPs rs1050450 in the GPX1 gene, rs1695 and rs1138272 in the GSTP1 gene and rs4880 in the MnSOD gene) with the risk of prostate cancer.
|
24610081 |
2014 |
|
rs4880
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Statistically significant effect modification of both HCA (DiMeIQx) and darkly browned meat intake and PCa risk was observed for allelic variants of MnSOD (rs4880) (P(interaction): 0.02).
|
22564066 |
2012 |
|
rs4880
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We previously reported a statistically significant interaction between circulating selenium levels, variants in the superoxide dismutase 2 gene (SOD2; rs4880), and risk of developing prostate cancer and presenting with aggressive prostate cancer.
|
20477822 |
2011 |
|
rs4880
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A high tertile selenium level in combination with non-wt rs125701 of the OGG1 gene in combination with smoking status or rs4880 related variation of MnSOD gene appeared to protect from PrCa.
|
21982398 |
2011 |
|
rs4880
|
|
|
0.100 |
GeneticVariation |
BEFREE |
MnSOD Val16Ala polymorphism and prostate cancer susceptibility: a meta-analysis involving 8,962 subjects.
|
20012093 |
2010 |
|
rs4880
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Manganese superoxide dismutase (MnSOD) Val16Ala polymorphism has been recently associated with breast and prostate cancer.
|
18553161 |
2009 |
|
rs4880
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No significant association was found between the Ala-9Val and Ala-16Val polymorphisms in MnSOD and prostate cancer susceptibility.
|
19647296 |
2009 |
|
rs4880
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Selenium status also modifies the effect of the mitochondrial superoxide dismutase (SOD2) SNP Ala16Val on prostate cancer risk.
|
19074884 |
2008 |
|
rs4880
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this cohort of mainly white men, the MnSOD gene Ala16Val polymorphism was not associated with total or aggressive prostate cancer risk.
|
18784358 |
2008 |
|
rs4880
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Associations between MPO -463 G to A genotype (rs2333227) and prostate cancer risk were only noted among men with aggressive cancer, with more than a 2-fold risk reduction among men with AA genotypes (OR = 0.4, 95% CI = 0.2-1.0); MnSOD was not associated with risk overall, but the MnSOD T to C (Val-9Ala, rs4880) polymorphism modified associations between risk of clinically aggressive prostate cancer and dietary iron intake (P for interaction = 0.02).
|
18296681 |
2008 |
|
rs4880
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The higher activity Ala variant at SOD2 Ex2+24T>C (V16A), which has been hypothesized to suppress prostate carcinogenesis, was associated with elevation of prostate cancer risk in Caucasians (Val/Ala versus Val/Val: OR, 1.17; 95% CI, 0.97-1.42; Ala/Ala versus Val/Val: OR, 1.28; 95% CI, 1.03-1.60; P(trend) = 0.03).
|
17646272 |
2007 |
|
rs953038635
|
|
|
0.020 |
GeneticVariation |
BEFREE |
No significant association was found between the Ala-9Val and Ala-16Val polymorphisms in MnSOD and prostate cancer susceptibility.
|
19647296 |
2009 |
|
rs953038635
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Effects of manganase superoxide dismutase Ala-9Val polymorphism on prostate cancer: a case-control study.
|
17465268 |
2007 |
|
rs2758331
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among patients who underwent RT in the test cohort, there was a significant association between 3 of the 7 SOD2 SNPs and lethal prostate cancer: rs6917589 (overall P = .006), rs2758331 (P = .04) and the functional valine to alanine polymorphism in rs4880 (P = .04).
|
25662905 |
2015 |
|
rs6917589
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among patients who underwent RT in the test cohort, there was a significant association between 3 of the 7 SOD2 SNPs and lethal prostate cancer: rs6917589 (overall P = .006), rs2758331 (P = .04) and the functional valine to alanine polymorphism in rs4880 (P = .04).
|
25662905 |
2015 |
|
rs5746136
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data showed that rs5746136 of SOD2 was associated with susceptibility to PCa in the Chinese population of Han nationality.
|
22959522 |
2012 |
|
rs2758330
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two variants in SOD2 were significantly associated with the risk of aggressive prostate cancer (rs17884057, odds ratio 0.83, 95% confidence interval 0.70-0.99; and rs4816407, 1.27, 1.02-1.57); men with A alleles at rs2842958 in SOD2 had lower plasma selenium levels (median 116 vs 121.8 µg/L, P= 0.03); and the association between plasma selenium levels and risk of aggressive prostate cancer was modified by SOD1 (rs10432782) and SOD2 (rs2758330).
|
20477822 |
2011 |
|
rs2842958
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two variants in SOD2 were significantly associated with the risk of aggressive prostate cancer (rs17884057, odds ratio 0.83, 95% confidence interval 0.70-0.99; and rs4816407, 1.27, 1.02-1.57); men with A alleles at rs2842958 in SOD2 had lower plasma selenium levels (median 116 vs 121.8 µg/L, P= 0.03); and the association between plasma selenium levels and risk of aggressive prostate cancer was modified by SOD1 (rs10432782) and SOD2 (rs2758330).
|
20477822 |
2011 |