|
rs8099917
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The main outcomes of the study were to assess whether IL28B rs12979860 and rs8099917 polymorphisms, together with PNPLA3 rs738409 C>G polymorphism, are associated with lobular inflammation and fibrosis, in NAFLD patients.
|
22314430 |
2012 |
|
rs8099917
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In addition, we found that rs8099917 polymorphism is not a risk factor for predisposition to NAFLD in a sample of Iranian population.
|
22257210 |
2012 |
|
rs1024611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the gene polymorphisms of MCP-1 (-2518 A/G) (rs1024611), CCR-2 (190 G/A) (rs1799864), ABCA1 (883 G/A) (rs4149313), and IL-17A (-197 G/A) (rs2275913) in obese Turkish children with non-alcoholic fatty liver disease.
|
29733805 |
2019 |
|
rs10883437
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we accessed the seven polymorphisms of rs1260326, rs780094 in GCKR, rs2954021 near TRIB1, rs2228603 in NCAN, rs58542926 in TM6SF2, rs12137855 near LYPLAL1, and rs10883437 near CPN1 on NAFLD susceptibility in the Uygur population.
|
30646922 |
2019 |
|
rs1263173
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The genotypes of rs10750097(G/G), rs1263173(A/A), rs17120035(T/T), and rs662799(G/G) performed a significant effect on clinic characteristics in overall series and NAFLD patients, indicating that these polymorphisms may be associated with NAFLD.
|
29735301 |
2018 |
|
rs12970134
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The FTO rs9939609 A-allele increased risk of NAFLD and MC4R rs12970134 was associated with ALT level through an effect on BMI.
|
24458218 |
2014 |
|
rs12980275
|
|
|
0.010 |
GeneticVariation |
BEFREE |
NAFLD patients without fibrosis had a higher frequency of IL28B rs12979860 TT and rs12980275 GG genotypes compared with NAFLD patients with fibrosis (P<0.005).
|
28253210 |
2017 |
|
rs16996148
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotyping data of five SNPs, rs58542926, rs735273, rs1009136, rs1858999, and rs16996148, were used to verify the effect on serum lipid levels by multiple linear regression, and the association with NAFLD in the Japanese population was examined by logistic regression analysis.
|
26758378 |
2016 |
|
rs17782313
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our aim was to identify whether the obesity-susceptible gene variants (rs9939609, rs9930506, and rs4783819 in fat mass and obesity-associated gene (FTO); rs12970134 and rs17782313 in melanocortin-4 receptor gene (MC4R); and rs7566605, rs13428113, and rs9308762 in insulin-induced gene 2 [INSIG2]) were associated with NAFLD.
|
24458218 |
2014 |
|
rs2954029
|
|
|
0.010 |
GeneticVariation |
BEFREE |
TRIB1 rs17321515 and rs2954029 were significant associated with the risk of NAFLD in Chinese Han population.
|
30851741 |
2019 |
|
rs499765
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The variant rs499765 adjacent to FGF21 is associated with serum FGF21 levels and NAFLD in a Chinese nondiabetic population.
|
25359230 |
2014 |
|
rs5748926
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also identified novel loci for NAFLD disease severity, including one novel locus for NAS score near IL17RA (rs5748926, p = 3.80 × 10<sup>- 8</sup>), and another near ZFP90-CDH1 for fibrosis (rs698718, p = 2.74 × 10<sup>- 11</sup>).
|
31311600 |
2019 |
|
rs6834314
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found two plausible causative variants in the HSD17B13 gene. rs72613567, a splice-site SNP in high linkage with rs6834314 (r<sup>2</sup> = 0.94) generates splice variants and shows a similar pattern of association with NAFLD histology.
|
30415504 |
2019 |
|
rs6982502
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A TRIB1 SNP, rs6982502, was identified in an enhancer sequence, modulated enhancer activity in reporter gene assays, and was significantly (P=9.39 × 10(-7)) associated with ultrasonographically diagnosed non-alcoholic fatty liver disease in a population of 5570 individuals.
|
24389359 |
2014 |
|
rs4149267
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study aimed to investigate the feasibility of a new index comprehensive index (CI), consisting of 6 serum biomarkers and anthropometric parameters through multivariate logistic regression analysis, to the earlier detection of NAFLD, and the diagnostic value of 5 SNPs (S1: rs2854116 of apolipoprotein C3 [APOC3], S2: rs4149267 of ATP-binding cassette transporter [ABCA1], S3: rs13702 of lipoprotein lipase [LPL], S4: rs738409 of protein 3 [patatin-like phospholipase domain containing protein 3 (PNPLA3)], S5: rs780094 of glucokinase regulatory protein gene [GCKR]) for NAFLD were also explored.
|
29595690 |
2018 |
|
rs4149313
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the gene polymorphisms of MCP-1 (-2518 A/G) (rs1024611), CCR-2 (190 G/A) (rs1799864), ABCA1 (883 G/A) (rs4149313), and IL-17A (-197 G/A) (rs2275913) in obese Turkish children with non-alcoholic fatty liver disease.
|
29733805 |
2019 |
|
rs17222723
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When we tested the hypothesis of a relation between gene variants and the clinical and histological spectra of NAFLD by multinomial regression analysis, a significant association was observed with the same markers: rs1</span>7222723 (P=.0029) and rs8187710 (P=.015).
|
18926681 |
2009 |
|
rs8187710
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When we tested the hypothesis of a relation between gene variants and the clinical and histological spectra of NAFLD by multinomial regression analysis, a significant association was observed with the same markers: rs17222723 (P=.0029) and rs8187710 (P=.015).
|
18926681 |
2009 |
|
rs6128907
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Genome-Wide Associations Related to Hepatic Histology in Nonalcoholic Fatty Liver Disease in Hispanic Boys.
|
28918882 |
2017 |
|
rs266729
|
|
|
0.040 |
GeneticVariation |
BEFREE |
ADIPOQ G rs266729 and TNF- 308 A allele are associated with obesity, MetS/NAFLD and insulin resistance.
|
31659105 |
2020 |
|
rs266729
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In patients with type 2 diabetes gene polymorphism of adiponectin rs266729 is associated with risk of NAFLD.
|
26042596 |
2015 |
|
rs266729
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our results support an important association of the rs266729 (-11377 G/C) and rs822393 (-4522 C/T) polymorphism with increased risk of NAFLD.
|
26865047 |
2016 |
|
rs266729
|
|
|
0.040 |
GeneticVariation |
BEFREE |
This study aimed to investigate the association between ADIPOQ polymorphisms (+276G>T, rs1501299 and -11377C>G, rs266729) and the risk of NAFLD.
|
30838812 |
2019 |
|
rs822393
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results support an important association of the rs266729 (-11377 G/C) and rs822393 (-4522 C/T) polymorphism with increased risk of NAFLD.
|
26865047 |
2016 |
|
rs1501299
|
|
|
0.040 |
GeneticVariation |
BEFREE |
CONCLUSIONS Results from our current meta-analysis gave insight into the correlation between rs1501299 polymorphism and the risk of NAFLD,</span> indicating the variant of rs1501299</span> might be related to increased NAFLD susceptibility.
|
30735485 |
2019 |