|
rs779944215
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
ADCY10 frameshift variant leading to severe recessive asthenozoospermia and segregating with absorptive hypercalciuria.
|
31119281 |
2019 |
|
rs193143625
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Homozygosity of the GFPT2 p.Arg366Gln mutation was associated with increased levels of reactive oxygen species (ROS) in spermatozoa and decreased sperm motility.
|
30849544 |
2019 |
|
rs215702
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, positive associations were observed between asthenozoospermia and rs215702 in LSM5 (P = 0.0016, OR = 1.479, 95% CI: 1.075-2.033) and between oligoasthenozoospermia and rs2477686 in PEX10 (P = 0.0011, OR = 2.935, 95% CI: 1.492-5.775).
|
27232852 |
2018 |
|
rs2477686
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, positive associations were observed between asthenozoospermia and rs215702 in LSM5 (P = 0.0016, OR = 1.479, 95% CI: 1.075-2.033) and between oligoasthenozoospermia and rs2477686 in PEX10 (P = 0.0011, OR = 2.935, 95% CI: 1.492-5.775).
|
27232852 |
2018 |
|
rs3216733
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that rs3216733 was associated with increased risk of AZS (Gd vs. dd: adjusted OR = 1.42, 95% CI, 1.06-1.93, P = 0.020; Gd/GG vs. dd: adjusted OR = 1.43, 95% CI, 1.08-1.91, P = 0.013; G vs. d adjusted OR = 1.26, 95% CI, 1.03-1.56, P = 0.027).
|
30229503 |
2018 |
|
rs3788862
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MAOA rs3788862 G carriers displayed an increased risk of asthenozoospermia (OR = 2.29; P = 0.02).
|
29602729 |
2018 |
|
rs6313
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Men with HTR2A rs6313 had a higher risk of asthenozoospermia (OR = 2.14; P = 0.04).
|
29602729 |
2018 |
|
rs11614913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In following stratified analysis, we found that rs11614913 exhibited a significantly higher risk of asthenospermia, oligozoospermia and azoospermia.
|
26805933 |
2016 |
|
rs116893490
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggested that tektin-t variants (Arg/Cys + Cys/Cys) were probably one of the high risk genetic factors for idiopathic asthenozoospermia among males in Sichuan, China, while the R207H polymorphism may be associated with idiopathic asthenozoospermia risk.
|
26584823 |
2016 |
|
rs147894843
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Other variants identified in SEMGs possibly contributing to hyperviscosity and asthenozoospermia consisted of three replacements predicted to modify targets of proteolysis (P = 0.0442 for SEMG1 p.Gly400Asp) and a copy number variation associated with a reduced risk of oligozoospermia (P = 0.0293).
|
27827323 |
2016 |
|
rs1799983
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant association was identified on allelic level between 4a4b variant and AZS in our study (chi-squared = 7.53, corrected P = 0.018, odds ratio (OR) = 1.808), while there were no significant difference of T-786C and G894T for asthenozoospermia in both genotype and allele distributions.
|
25505202 |
2015 |
|
rs1893316
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In particular, the exonal SNP rs1893316 in CATSPER1 significantly correlated with idiopathic asthenospermia risk and is a potential important factor in determining an individual's genetic susceptibility to idiopathic asthenospermia.
|
26354096 |
2015 |
|
rs140210148
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we report on three heterozygous SLC26A8 missense mutations identified in a cohort of 146 men presenting with asthenozoospermia: c.260G>A (p.Arg87Gln), c.2434G>A (p.Glu812Lys), and c.2860C>T (p.Arg954Cys).
|
23582645 |
2013 |
|
rs1042064
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results demonstrated that rs1042064 of EPHX2 was significantly associated with decreased risk of oligozoospermia (OR=0.65, 95% CI: 0.44-0.98) and asthenospermia (OR=0.66, 95% CI: 0.46-0.94).
|
22986331 |
2012 |
|
rs199696526
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The patient carrying SEPT12(D197N) presented with oligoasthenozoospermia, whereas the SEPT12(T89M) patient had asthenoteratozoospermia.
|
22275165 |
2012 |
|
rs371195126
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The patient carrying SEPT12(D197N) presented with oligoasthenozoospermia, whereas the SEPT12(T89M) patient had asthenoteratozoospermia.
|
22275165 |
2012 |
|
rs142723316
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A possible association of a human tektin-t gene mutation (A229V) with isolated non-syndromic asthenozoospermia: case report.
|
18227105 |
2008 |