Gene: FGFR2 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs79184941
rs79184941
FGFR2
0.710 GeneticVariation BEFREE FGFR2 exons 7 and 12 unlabeled DNA probes allow for easy screening of endometrial carcinoma for the 2 most common FGFR2 mutations (S252W and N550K). 21285871

2011
dbSNP: rs79184941
rs79184941
FGFR2
C 0.710 CausalMutation CLINVAR

dbSNP: rs121913478
rs121913478
FGFR2
C 0.700 CausalMutation CLINVAR

dbSNP: rs1057519854
rs1057519854
FGFR2
0.020 GeneticVariation BEFREE We cultured BaF3 cells overexpressing FGFR2 in high concentrations of dovitinib and identified 14 dovitinib-resistant mutations, including the N550K mutation observed in 25% of FGFR2(mutant) endometrial cancers (ECs). 23908597

2013
dbSNP: rs121913476
rs121913476
FGFR2
0.020 GeneticVariation BEFREE We cultured BaF3 cells overexpressing FGFR2 in high concentrations of dovitinib and identified 14 dovitinib-resistant mutations, including the N550K mutation observed in 25% of FGFR2(mutant) endometrial cancers (ECs). 23908597

2013
dbSNP: rs1057519854
rs1057519854
FGFR2
0.020 GeneticVariation BEFREE FGFR2 exons 7 and 12 unlabeled DNA probes allow for easy screening of endometrial carcinoma for the 2 most common FGFR2 mutations (S252W and N550K). 21285871

2011
dbSNP: rs121913476
rs121913476
FGFR2
0.020 GeneticVariation BEFREE FGFR2 exons 7 and 12 unlabeled DNA probes allow for easy screening of endometrial carcinoma for the 2 most common FGFR2 mutations (S252W and N550K). 21285871

2011
dbSNP: rs121918497
rs121918497
FGFR2
0.010 GeneticVariation BEFREE The mutation c.879C>T (p.Q289P) was first reported in endometrial cancer. 25517871

2015
dbSNP: rs1438956733
rs1438956733
FGFR2
0.010 GeneticVariation BEFREE The mutation c.879C>T (p.Q289P) was first reported in endometrial cancer. 25517871

2015
dbSNP: rs55745510
rs55745510
FGFR2
0.010 GeneticVariation BEFREE The mutation c.879C>T (p.Q289P) was first reported in endometrial cancer. 25517871

2015
dbSNP: rs1219648
rs1219648
FGFR2
0.010 GeneticVariation BEFREE We also observed a nonsignificant inverse association with rs889312 (MAP3K1) variant carriers [OR = 0.85 (95% CI: 0.68-1.05)] and rs1219648 (FGFR2) variant carriers [OR= 0.86 (95% CI: 0.69-1.06) and endometrial cancer risk. 18785201

2008