Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs7553007
rs7553007 		0.010 GeneticVariation BEFREE Both the CRP SNP rs7553007 and KRAS/BRAF mutations were independent prognostic factors for CRC patients with synchronous liver metastasis. 23755178

2014
dbSNP: rs1052133
rs1052133
OGG1 ; CAMK1
0.010 GeneticVariation BEFREE Increased frequency of Ser/Ser genotype of hOGG1 Ser326Cys was found to be associated both with higher grade (p = 0.001, OR: 6.4; 95% CI: 2.69-62.69) and liver metastasis (p = 0.005, OR: 7.5; 95% CI: 0.7-68.36). 21561390

2011
dbSNP: rs75873440
rs75873440
RET
0.010 GeneticVariation BEFREE Moreover, RET p.G533C-expressing cells were able to induce liver metastasis in nude mice. 21834681

2011
dbSNP: rs1042522
rs1042522
TP53
0.010 GeneticVariation BEFREE The p53 R72P genotype was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 78 consecutive colorectal cancer patients with liver metastases and 214 age- and sex-matched cases with nonmetastatic colorectal cancer. 18988302

2008
dbSNP: rs1131691014
rs1131691014
TP53
0.010 GeneticVariation BEFREE The p53 R72P genotype was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 78 consecutive colorectal cancer patients with liver metastases and 214 age- and sex-matched cases with nonmetastatic colorectal cancer. 18988302

2008
dbSNP: rs4872077
rs4872077
TNFRSF10A
0.010 GeneticVariation BEFREE A novel germline truncating mutation of DR5/TNFRSF10B was identified, and DR4/TNFRSF10A SNP rs4872077 was associated with the development of liver metastases (p = 0.02). 18590575

2008
dbSNP: rs878854066
rs878854066
TP53
0.010 GeneticVariation BEFREE The p53 R72P genotype was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 78 consecutive colorectal cancer patients with liver metastases and 214 age- and sex-matched cases with nonmetastatic colorectal cancer. 18988302

2008
dbSNP: rs879253942
rs879253942
TP53
0.010 GeneticVariation BEFREE Liver metastases (n = 93) along with primary tumors (n = 48) were analyzed for K-Ras mutations (codons 12 and 13), p53 mutations (exons 4-9), p53 polymorphism (codon 72), thymidylate synthase (TS) polymorphism (28-bp repeats including G>C mutation), methylenetetrahydrofolate reductase polymorphism (677C>T, 1298A>C), thymidylate synthase (TS) activity, dihydropyrimidine dehydrogenase activity, folylpolyglutamate synthase activity, and p53 protein expression. 18676755

2008
dbSNP: rs1217691063
rs1217691063
MTHFR
0.010 GeneticVariation BEFREE 677C>T and 1298A>C genotypes were determined simultaneously by melting curve analyses on liver metastases. 15608557

2004
dbSNP: rs397507444
rs397507444
MTHFR
0.010 GeneticVariation BEFREE 677C>T and 1298A>C genotypes were determined simultaneously by melting curve analyses on liver metastases. 15608557

2004