|
rs11966728
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The genotyping of six polymorphisms (rs6917644, rs9399005, rs6918698, rs9493150, rs2151532 and rs11966728) covering the CTGF locus in 365 patients suffering from chronic hepatitis C revealed that none of these polymorphisms showed a genotypic or allelic association with the severity of hepatic fibrosis.
|
19243500 |
2009 |
|
rs12075
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Impact of <i>DARC</i> rs12075 Variants on Liver Fibrosis Progression in Patients with Chronic Hepatitis C: A Retrospective Study.
|
30970632 |
2019 |
|
rs1217691063
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and high plasma homocysteine in chronic hepatitis C (CHC) infected patients from the Northeast of Brazil.
|
21854603 |
2011 |
|
rs1217691063
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Hyperhomocysteinemia and the MTHFR C677T polymorphism promote steatosis and fibrosis in chronic hepatitis C patients.
|
15834927 |
2005 |
|
rs1217691063
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, being a putative steatogenic factor, may promote liver fibrosis progression in patients with chronic hepatitis C. This study aimed to verify the role of recipient MTHFR polymorphism in favouring graft fibrosis progression in patients with recurrent HCV after orthotopic liver transplantation (OLT).
|
17900242 |
2008 |
|
rs12785878
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The well-known associations between CYP2R1 (rs1993116, rs10741657), GC (rs2282679), and DHCR7 (rs7944926, rs12785878) genotypes and 25(OH)D3 serum levels were also apparent in patients with chronic hepatitis C. The same genotypes of these single nucleotide polymorphisms (SNPs) that are associated with reduced 25(OH)D3 serum levels were found to be associated with HCV-related HCC (P = 0.07 [OR = 1.13, 95% CI = 0.99-1.28] for CYP2R1, P = 0.007 [OR = 1.56, 95% CI = 1.12-2.15] for GC, P = 0.003 [OR = 1.42, 95% CI = 1.13-1.78] for DHCR7; ORs for risk genotypes).
|
23734184 |
2013 |
|
rs1293762
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Data obtained suggest that the OAS2 rs1293762 and CD209 rs2287886 SNPs are associated with predisposition to chronic hepatitis C in Russian population.
|
24594345 |
2014 |
|
rs12952093
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Suppressor of cytokine signalling 3 is thought to be associated with insulin resistance in patients with chronic hepatitis C. We evaluated the role of suppressor of cytokine signalling 3 polymorphisms in determining insulin resistance in patients with chronic hepatitis C. Two hundred and ninety untreated hepatitis C virus-infected patients without diabetes and cirrhosis were genotyped for the SNPs rs4969168, rs4969170 and rs12952093 of suppressor of cytokine signalling 3 using the TaqMan Genotyping Assay.
|
23490372 |
2013 |
|
rs12972991
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance.
|
19684573 |
2009 |
|
rs12979860
|
|
|
0.900 |
GeneticVariation |
BEFREE |
With the screening for IL28B polymorphisms rs12980275, rs8099917 and rs12979860, which are associated with HCV chronicity and with reduced SVR rates, an important prognostic factor of the therapy of chronic hepatitis C can be easily diagnosed.
|
21149916 |
2010 |
|
rs12979860
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Role of interleukin 28B rs12979860 C/T polymorphism on the histological outcome of chronic hepatitis C: relationship with gender and viral genotype.
|
21647799 |
2011 |
|
rs12979860
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These results demonstrate that the genotypes rs12979860 CC and rs8099917 TT were more frequently observed in Korean patients compared to other ethnicities, and suggest that the genetic characteristics of patients may be prognostic factor that predicts antiviral response to PEG-IFN therapy for chronic hepatitis C.
|
21907615 |
2011 |
|
rs12979860
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A single-nucleotide polymorphism (SNP) near the IL28B gene (rs12979860) strongly predicts sustained virological response to pegylated interferon plus ribavirin (pegIFN-RBV) treatment for chronic hepatitis C virus (HCV) infection.
|
20964522 |
2010 |
|
rs12979860
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Polymorphisms of inosine triphosphate pyrophosphatase (rs1127354 and rs6051702) and interferon lambda 4 (IFLN4) (rs12979860) are indicators of anemia and/or sustained virological response (SVR) in patients with chronic hepatitis C on ribavirin/interferon.
|
31359493 |
2020 |
|
rs12979860
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Patients requiring liver transplantation due to end-stage chronic hepatitis C appeared to be selected toward the adverse genotypes rs12979860 CT/TT compared to non-transplanted HCV-infected patients (p=0.046).
|
21147186 |
2011 |
|
rs12979860
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A prospective study was conducted including 474 (250 genotype 1, 224 genotype 2) consecutive chronic hepatitis C (CHC) patients who had completed an anti-HCV therapy course and undergone pre-therapy and 24-week post-therapy assessments of interferon λ3-rs12979860 and HCV RNA/genotypes, anthropometric measurements, metabolic and liver profiles, and complement component 3 (C3), C4, and leptin levels.
|
27870883 |
2016 |
|
rs12979860
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recent studies in chronic hepatitis C patients have shown that rs368234815 polymorphism nearby IL28B is a better predictor of response to antiviral treatment with pegylated interferon and ribavirin than IL28B polymorphisms (rs12979860 and rs8099917).
|
25130512 |
2014 |
|
rs12979860
|
|
|
0.900 |
GeneticVariation |
BEFREE |
41 patients with genotype 1 chronic hepatitis C infection from the Duke Liver Clinic were genotyped for rs12979860.
|
21750736 |
2011 |
|
rs12979860
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Recent genome-wide association studies revealed the rs12979860 single nucleotide polymorphism (SNP) of the IL28B gene (CC genotype) to be the strongest pre-therapeutic predictor of therapy response to interferon alpha in patients with chronic hepatitis C infection.
|
25389973 |
2014 |
|
rs12979860
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Vitamin D serum levels are complementary to the IL-28B rs12979860 C/T polymorphism in enhancing the correct prediction of the SVR in treatment-naïve chronic hepatitis C.
|
21480318 |
2011 |
|
rs12979860
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance.
|
19684573 |
2009 |
|
rs12979860
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To assess the role of the ss469415590 variant, compared with the known IL28B polymorphisms (rs8099917, rs12979860 and rs12980275) for predicting virological response to therapy in chronic hepatitis C, and its association with the CXCL10 chemokine serum levels - a surrogate marker of interferon-stimulated genes activation.
|
24308755 |
2014 |
|
rs12979860
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance.
|
19684573 |
2009 |
|
rs12979860
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate the association between the IL28B gene polymorphism (rs12979860) and virological response in chronic hepatitis C patients.
|
23440114 |
2013 |
|
rs12979860
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Frequency of IL28B rs12979860 single-nucleotide polymorphism alleles in newborn infants and in patients with chronic hepatitis C in Morocco.
|
22509814 |
2012 |