Gene: COMT ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4680
rs4680
COMT ; MIR4761
0.040 GeneticVariation BEFREE Association of the COMT synonymous polymorphism Leu136Leu and missense variant Val158Met with mood disorders. 25766270

2015
dbSNP: rs4680
rs4680
COMT ; MIR4761
0.040 GeneticVariation BEFREE COMT Val158Met was not associated with anxiety or mood disorders in either gender. 23928267

2013
dbSNP: rs4680
rs4680
COMT ; MIR4761
0.040 GeneticVariation BEFREE Results indicate a main as well as a GxE effect of the COMT Val158Met variant and childhood maltreatment on the affect-modulated startle reflex, supporting a complex pathogenetic model of the affect-modulated startle reflex as a basic neurobiological defensive reflex potentially related to anxiety and affective disorders. 22745815

2012
dbSNP: rs4680
rs4680
COMT ; MIR4761
0.040 GeneticVariation BEFREE The COMT-V158M polymorphism was not associated with suicidal behavior in a Caucasian sample of mood disorder subjects, or with possible clinical or biological endophenotypes. 18828035

2008
dbSNP: rs1445081098
rs1445081098
COMT ; MIR4761
0.010 GeneticVariation BEFREE We studied the possible association between the prophylactic efficacy of lithium in mood disorders and the following gene variants: catechol-O-methyltransferase (COMT) G158A, monoamine oxydase A (MAO-A) 30-bp repeat, G-protein beta 3-subunit (Gbeta3) C825T. 11992559

2002