Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs104893877
rs104893877
SNCA
0.010 GeneticVariation BEFREE Our results directly implicate tau as a mediator of specific human mutant A53T αS-mediated abnormalities related to deficits in hippocampal neurotransmission and suggest a mechanism for memory impairment that occurs as a consequence of synaptic dysfunction rather than synaptic or neuronal loss. 31168644

2019
dbSNP: rs767543900
rs767543900
MAPT
0.010 GeneticVariation BEFREE Our results directly implicate tau as a mediator of specific human mutant A53T αS-mediated abnormalities related to deficits in hippocampal neurotransmission and suggest a mechanism for memory impairment that occurs as a consequence of synaptic dysfunction rather than synaptic or neuronal loss. 31168644

2019
dbSNP: rs63750577
rs63750577
PSEN1
0.010 GeneticVariation BEFREE The clinical phenotype was consistent regarding initial memory impairment and early onset in the late twenties found in all S170F patients. 29466804

2018
dbSNP: rs11142387
rs11142387 		0.010 GeneticVariation BEFREE In particular, carrying the A allele of rs11142387 near KLF9 was found to be associated with psychiatric disease and poor memory performance, which warrants further investigations. 27923415

2017
dbSNP: rs74315408
rs74315408
PRNP
0.010 GeneticVariation BEFREE Here, we report the first case of V180I rare mutation in a Brazilian woman whose clinical condition started with memory impairment for recent events and insomnia with 2 months of evolution, without any other alterations in neurological examination. 29095671

2017
dbSNP: rs775129479
rs775129479
IGFALS ; SPSB3
0.010 GeneticVariation BEFREE In TUBA4A, we detected a novel frameshift mutation (p.Arg64Glyfs*90) leading to a truncated protein in 1 FTD patient (1/459 of 0.22%) with family history of Parkinson's disease and cognitive impairment, and a novel missense mutation (p.Thr381Met) in 2 sibs with familial ALS and memory problems (1 index patient/429, 0.23%) in whom we previously identified a pathogenic Chromosome 9 open reading frame 72 repeat expansion mutation. 28069311

2017
dbSNP: rs781587642
rs781587642
TUBA4A ; STK16
0.010 GeneticVariation BEFREE In TUBA4A, we detected a novel frameshift mutation (p.Arg64Glyfs*90) leading to a truncated protein in 1 FTD patient (1/459 of 0.22%) with family history of Parkinson's disease and cognitive impairment, and a novel missense mutation (p.Thr381Met) in 2 sibs with familial ALS and memory problems (1 index patient/429, 0.23%) in whom we previously identified a pathogenic Chromosome 9 open reading frame 72 repeat expansion mutation. 28069311

2017
dbSNP: rs11136000
rs11136000
CLU
0.010 GeneticVariation BEFREE Interestingly, the complex communications between resting-state networks were enhanced in aMCI subjects with the CLU rs11136000 CC genotype and were modulated by the degree of memory impairment, suggesting a reconstructed balance of the resting-state networks in these individuals with an elevated risk of AD. 26899953

2016
dbSNP: rs6265
rs6265
BDNF ; BDNF-AS
0.010 GeneticVariation BEFREE BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease. 27521573

2016
dbSNP: rs759834365
rs759834365
BDNF ; BDNF-AS
0.010 GeneticVariation BEFREE BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease. 27521573

2016
dbSNP: rs763868966
rs763868966
GFAP
0.010 GeneticVariation BEFREE We found a novel nonsense mutation (c.1000 G>T, p.(Glu312Ter); also termed p.(E312*)</span>) within a rod domain of GFAP in a 67-year-old Korean man with a history of memory impairment and leukoencephalopathy. 24755947

2015
dbSNP: rs1424266770
rs1424266770
CASP3
0.010 GeneticVariation BEFREE H63D mutation in hemochromatosis alters cholesterol metabolism and induces memory impairment. 24439478

2014
dbSNP: rs1799945
rs1799945
HFE ; LOC108783645
0.010 GeneticVariation BEFREE H63D mutation in hemochromatosis alters cholesterol metabolism and induces memory impairment. 24439478

2014
dbSNP: rs63751273
rs63751273
MAPT
0.010 GeneticVariation BEFREE Forebrain-specific over-expression of human tau(P301L), a mutation associated with frontotemporal dementia with parkinsonism linked to chromosome 17, in rTg4510 mice results in the formation of NFTs, learning and memory impairment and massive neuronal death. 22027994

2012
dbSNP: rs8074995
rs8074995
PRKCA
0.010 GeneticVariation BEFREE Single nucleotide polymorphism (SNP) rs8074995 lies within the PRKCA region spanned by a rare haplotype associated with schizophrenia in a recent UK study and provides further evidence of PRKCA contribution to memory impairment and susceptibility to schizophrenia. 21281445

2011
dbSNP: rs281865071
rs281865071
CHRNB2
0.010 GeneticVariation BEFREE Autosomal dominant nocturnal frontal lobe epilepsy and mild memory impairment associated with CHRNB2 mutation I312M in the neuronal nicotinic acetylcholine receptor. 18534914

2008
dbSNP: rs781049584
rs781049584
APP
0.010 GeneticVariation BEFREE Mice carrying mutated human APPswe and PS1 (A246E) transgenes (A/P mice) show age-dependent memory impairment in hippocampus-dependent tasks. 15006688

2004
dbSNP: rs17125721
rs17125721
PSEN1
0.010 GeneticVariation BEFREE Association between the presenilin-1 mutation Glu318Gly and complaints of memory impairment. 11755019

2002