Gene: RET ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs75076352
rs75076352
RET
0.710 GeneticVariation BEFREE In the present study, we investigated whether the oncogenic RET mutants RET2A (C634R) and RET2B (M918T) were regulated by LRIG1, and the possible effects of LRIG1 expression in thyroid cancer were investigated in three different clinical cohorts and in a RET2B-driven mouse model of MTC. 29436694

2018
dbSNP: rs75076352
rs75076352
RET
C 0.710 CausalMutation CLINVAR High penetrance of pheochromocytoma in multiple endocrine neoplasia 2 caused by germ line RET codon 634 mutation in Japanese patients. 23416954

2013
dbSNP: rs75076352
rs75076352
RET
C 0.710 CausalMutation CLINVAR The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins. 16778204

2006
dbSNP: rs75076352
rs75076352
RET
C 0.710 CausalMutation CLINVAR Nuclear factor-kappaB is constitutively active in C-cell carcinoma and required for RET-induced transformation. 11389085

2001
dbSNP: rs121913308
rs121913308
RET
0.700 GeneticVariation UNIPROT

dbSNP: rs74799832
rs74799832
RET
0.030 GeneticVariation BEFREE In the present study, we investigated whether the oncogenic RET mutants RET2A (C634R) and RET2B (M918T) were regulated by LRIG1, and the possible effects of LRIG1 expression in thyroid cancer were investigated in three different clinical cohorts and in a RET2B-driven mouse model of MTC. 29436694

2018
dbSNP: rs74799832
rs74799832
RET
0.030 GeneticVariation BEFREE In present result, RET rs1799939, rs1800858 and rs74799832 polymorphisms might be the risk factors for TC. 26191299

2015
dbSNP: rs74799832
rs74799832
RET
0.030 GeneticVariation BEFREE CGH alterations in medullary thyroid carcinomas in relation to the RET M918T mutation and clinical outcome. 11351254

2001
dbSNP: rs79658334
rs79658334
RET
0.020 GeneticVariation BEFREE However, two gatekeeper mutations V804M and V804L in RET kinase domain have been frequently observed to cause drug resistance during the targeted therapy, largely limiting the application of reversible TKIs in TC. 27712045

2016
dbSNP: rs79658334
rs79658334
RET
0.020 GeneticVariation BEFREE A rapid method for the purification of wild-type and V804M mutant ret catalytic domain: A tool to study thyroid cancer. 16490247

2006
dbSNP: rs1799939
rs1799939
RET
0.010 GeneticVariation BEFREE In present result, RET rs1799939, rs1800858 and rs74799832 polymorphisms might be the risk factors for TC. 26191299

2015
dbSNP: rs1800858
rs1800858
RET
0.010 GeneticVariation BEFREE In present result, RET rs1799939, rs1800858 and rs74799832 polymorphisms might be the risk factors for TC. 26191299

2015
dbSNP: rs77724903
rs77724903
RET
0.010 GeneticVariation BEFREE We present a large kindred with the Y791F mutation in the RET proto-oncogene that did not have medullary thyroid carcinomas. 17483988

2007