rs1690916
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, the present meta-analysis indicates that MDM2 rs1690916 and rs2279744 cannot be considered as genetic risk factors for OS susceptibility in the different populations.
|
27438225 |
2016 |
rs2279744
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, the present meta-analysis indicates that MDM2 rs1690916 and rs2279744 cannot be considered as genetic risk factors for OS susceptibility in the different populations.
|
27438225 |
2016 |
rs1690916
|
|
|
0.020 |
GeneticVariation |
BEFREE |
MDM2 rs1690916 polymorphism was also associated with a risk of osteosarcoma (OR = 0.60, 95 % CI 0.46-0.77, P < 0.001).
|
24122202 |
2014 |
rs2279744
|
|
|
0.020 |
GeneticVariation |
BEFREE |
However, MDM2 rs2279744 polymorphism was not associated with the overall survival of patients with osteosarcoma (codominant model, HR = 1.01, 95 % CI 0.53-1.91, P = 0.98; recessive model, HR = 1.07, 95 % CI 0.54-2.11, P = 0.85; dominant model, HR = 1.04, 95 % CI 0.65-1.66, P = 0.87).
|
24122202 |
2014 |
rs780673045
|
|
|
0.020 |
GeneticVariation |
BEFREE |
As a whole, 11 of 29 (38%) analyzed OS presented alterations in some of the analyzed G1 to S-phase checkpoint genes.
|
15167009 |
2004 |
rs780673045
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The prevalence of these alterations, in conjunction with the reported inactivation of RB in up to 80% of cases, suggests that genetic lesions deregulating the G1 to S cell cycle checkpoint may be an almost constant feature in the pathogenesis of osteosarcoma.
|
9935200 |
1999 |
rs367597251
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Methods:</b> Osteosarcoma cancer cell line MG-63 was transfected with Ras gene with G12V and Y40C site mutation.
|
31126199 |
2019 |
rs756673959
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Methods:</b> Osteosarcoma cancer cell line MG-63 was transfected with Ras gene with G12V and Y40C site mutation.
|
31126199 |
2019 |
rs11177386
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Results from this study indicated that the allele-A and genotype-AA of MDM2 c.346G>A genetic variant could be an increased risk factor for the susceptibility to osteosarcoma and might be used as a potential molecular marker for evaluating the risk of osteosarcoma.
|
25551700 |
2015 |
rs199812774
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The T allele and TT genotype of c.44C>T and C allele and CC genotype of c.1002T>C could be increased risk factors for the susceptibility to OS.
|
23933591 |
2013 |
rs201821879
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The T allele and TT genotype of c.44C>T and C allele and CC genotype of c.1002T>C could be increased risk factors for the susceptibility to OS.
|
23933591 |
2013 |
rs1353702185
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The study provides evidence supporting the association of MDM2 SNP309 with high-grade osteosarcoma risk in females and shows that TP53 Arg72Pro has a prognostic value for overall survival and EFS in osteosarcoma patients.
|
19451596 |
2009 |