|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
A combined analysis with four additional studies (total: 4,296 cases and 4,299 controls) confirms association with prostate cancer for rs6983267 in the centromeric locus (P = 9.42 x 10(-13); heterozygote odds ratio (OR): 1.26, 95% confidence interval (c.i.): 1.13-1.41; homozygote OR: 1.58, 95% c.i.: 1.40-1.78).
|
17401363 |
2007 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Analysis of the National Cancer Institute's Cancer Genetic Markers of Susceptibility (CGEMS) prostate cancer association study database alone and in combination with our data provided further evidence for this second prostate cancer risk locus; in the combined analysis, the allele frequencies for rs6983267 differed statistically significantly between case patients and control subjects (P = 1.61 x 10(-9)).
|
17925536 |
2007 |
|
rs16901979
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We report that rs7008482, which maps to the 8q24.13 region, is an additional independent prostate cancer risk variant (P = 5 x 10(-4)), and we also replicate the association of rs16901979 with prostate cancer (P = 0.002).
|
17978284 |
2007 |
|
rs16901979
|
|
|
0.800 |
GeneticVariation |
BEFREE |
A meta-analysis across 10 studies including our results of four 8q24 variants (rs1442295 and DG8S737-region 1, rs16901979-region 2, and rs6983267-region 3) and prostate cancer risk demonstrated strong associations across a wide array of study designs and populations.
|
18231127 |
2008 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
A meta-analysis across 10 studies including our results of four 8q24 variants (rs1442295 and DG8S737-region 1, rs16901979-region 2, and rs6983267-region 3) and prostate cancer risk demonstrated strong associations across a wide array of study designs and populations.
|
18231127 |
2008 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We genotyped three variants associated with prostate cancer (rs10090154, rs13254738, and rs7000448), one associated with both prostate and colorectal cancer (rs6983267), and one associated with breast cancer (rs13281615) in a series of 1,499 breast cancer cases and 1,390 controls.
|
18349290 |
2008 |
|
rs13254738
|
|
|
0.720 |
GeneticVariation |
BEFREE |
This evidence of a protective effect for breast cancer of one variant (rs13254738) that has been associated previously with a 1.25-fold increased risk of prostate cancer, with no effect for the two other variants, indicates that the effects of the risk alleles clustered at 8q24 are cancer site specific.
|
18349290 |
2008 |
|
rs13281615
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We genotyped three variants associated with prostate cancer (rs10090154, rs13254738, and rs7000448), one associated with both prostate and colorectal cancer (rs6983267), and one associated with breast cancer (rs13281615) in a series of 1,499 breast cancer cases and 1,390 controls.
|
18349290 |
2008 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms (SNPs) rs6983561 and rs6983267 showed the strongest evidence of prostate cancer association.
|
18360876 |
2008 |
|
rs6983561
|
|
|
0.780 |
GeneticVariation |
BEFREE |
Notably, rs6983561 was significantly associated with prostate cancer among men diagnosed at an early (<50 years) but not later age (p = 0.03 versus p = 0.21).
|
18360876 |
2008 |
|
rs13281615
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Further studies are required to confirm whether the adjacent breast cancer-associated variant rs13281615 may be inversely associated with prostate cancer risk.
|
18625567 |
2009 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs6983267 G allele did not show significant association with susceptibility to PC (PC vs. non-PC: P = 0.967; OR, 1.00; 95%CI = 0.83-1.21).
|
18726982 |
2008 |
|
rs16901979
|
|
|
0.800 |
GeneticVariation |
BEFREE |
There was no joint effect between SNPs rs16901979 A and rs6983267 G. These results confirm the significance of these SNPs in prostate cancer etiology in a previously unstudied population who do not undergo prostate cancer screening and are diagnosed with severe disease.
|
18768513 |
2008 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
There was no joint effect between SNPs rs16901979 A and rs6983267 G. These results confirm the significance of these SNPs in prostate cancer etiology in a previously unstudied population who do not undergo prostate cancer screening and are diagnosed with severe disease.
|
18768513 |
2008 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
One marker, rs6983267 on chromosome 8q24, has been linked to both colon and prostate cancer, and is therefore a good candidate for a multicancer susceptibility marker.
|
19047180 |
2008 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The highest significance in Caucasian men was found for rs6983267; the AA genotype reduced the risk for PCa [odds ratio (OR) = 0.48, 95% confidence interval (CI) = 0.35-0.65, P = 2.74 x 10(-6)].
|
19528667 |
2009 |
|
rs16901979
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Two of these 17 SNPs, located at 3p12, and region 2 at 8q24, were significantly associated with prostate cancer risk (P < 0.05), and only SNP rs16901979 at region 2 of 8q24 remained significant after accounting for 20 tests.
|
19549807 |
2009 |
|
rs16901979
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Forty-nine tagging SNPs including three previously reported significant variants (rs1447295, rs6983267, rs16901979) and seven variants in the 5' upstream region of the MYC proto-oncogene were tested for association with susceptibility to PC and tumor aggressiveness in 596 histologically verified PC cases and 567 ethnically matched controls.
|
19562729 |
2009 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Forty-nine tagging SNPs including three previously reported significant variants (rs1447295, rs6983267, rs16901979) and seven variants in the 5' upstream region of the MYC proto-oncogene were tested for association with susceptibility to PC and tumor aggressiveness in 596 histologically verified PC cases and 567 ethnically matched controls.
|
19562729 |
2009 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The A allele of rs1447295 was significantly associated with the risk of sporadic prostate cancer (p = 0.04; age-adjusted OR, 1.34), while the G allele of rs6983267 showed a trend towards being a high-risk allele (p = 0.06; age-adjusted OR, 1.27).
|
19602258 |
2009 |
|
rs620861
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45).
|
19767755 |
2009 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism (SNP) rs6983267, located within the 8q24 region, is strongly associated with risk of colorectal and prostate cancer.
|
19895682 |
2009 |
|
rs16901979
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The variants rs16901979 and rs6983561 at 8q24 are associated with prostate cancer risk in Taiwanese men.
|
19908238 |
2010 |
|
rs6983561
|
|
|
0.780 |
GeneticVariation |
BEFREE |
The variants rs16901979 and rs6983561 at 8q24 are associated with prostate cancer risk in Taiwanese men.
|
19908238 |
2010 |
|
rs12334903
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three adjacent SNPs centromeric to prostate cancer risk-region 2 (rs12334903, rs1456310, and rs980171) were associated with testosterone (P < 1.1 x 10(-3)) and bioavailable testosterone (P < 6.3 x 10(-4)).
|
20551303 |
2010 |