|
rs16901946
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, four prostate cancer-associated ncRNA 1 (PRNCR1, rs16901946 G/A, rs13252298 G/A, rs1016343 T/C, and rs1456315 G/A) SNPs were in association with cancer risk.
|
29802154 |
2018 |
|
rs1902432
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Besides, rs1902432 in <i>PCAT1</i> was significantly associated with increased risk of PCa (Additive model: OR = 1.19, <i>P</i> = 0.014; Co-dominant model: CC <i>vs.</i> TT, OR = 1.45, <i>P</i> =0.012; Recessive model: CC <i>vs.</i> TT/CT, OR= 1.34, <i>P</i> = 0.027).
|
29721051 |
2018 |
|
rs7824364
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNP rs7824364, a local marker of WAA in the 8q24 region was associated with PCa among both AA and PR men and with increased WAA among PR men.
|
28543179 |
2017 |
|
rs7014346
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two signals were seen in regions already reported for prostate cancer risk. rs7014346 at 8q24.21 was marginally associated with aggressive prostate cancer in the BPC3 trial (p=1.6×10(-6)), whereas after meta-analysis by PRACTICAL the summary OR was 1.21 (95% CI 1.16-1.27; p=3.22×10(-18)). rs9900242 at 17q24.3 was also marginally associated with aggressive disease in the meta-analysis (OR 0.90, 95% CI 0.86-0.94; p=2.5×10(-6)).
|
25277271 |
2015 |
|
rs10505474
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs10505474 and rs7837328 at 8q24 cumulatively confer risk of prostate cancer in Northern Han Chinese.
|
24815458 |
2014 |
|
rs378854
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This approach identified rs378854, which is in complete linkage disequilibrium (LD) with rs620861, as a novel functional prostate cancer-specific genetic variant.
|
21814516 |
2011 |
|
rs7463708
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, focusing on its most centromeric region (so-called Region 2: Chr8: 128.14-128.28 Mb) among the multiple PC loci on 8q24, we performed fine mapping and re-sequencing of this critical region and identified SNPs (single nucleotide polymorphisms) between rs1456315 and rs7463708 (chr8: 128,173,119-128,173,237 bp) to be most significantly associated with PC susceptibility (P = 2.00 × 10(-24) , OR = 1.74, 95% confidence interval = 1.56-1.93).
|
20874843 |
2011 |
|
rs12334903
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three adjacent SNPs centromeric to prostate cancer risk-region 2 (rs12334903, rs1456310, and rs980171) were associated with testosterone (P < 1.1 x 10(-3)) and bioavailable testosterone (P < 6.3 x 10(-4)).
|
20551303 |
2010 |
|
rs980171
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three adjacent SNPs centromeric to prostate cancer risk-region 2 (rs12334903, rs1456310, and rs980171) were associated with testosterone (P < 1.1 x 10(-3)) and bioavailable testosterone (P < 6.3 x 10(-4)).
|
20551303 |
2010 |
|
rs7837328
|
|
|
0.020 |
GeneticVariation |
BEFREE |
rs10505474 and rs7837328 at 8q24 cumulatively confer risk of prostate cancer in Northern Han Chinese.
|
24815458 |
2014 |
|
rs7837328
|
|
|
0.020 |
GeneticVariation |
BEFREE |
To study the association between the polymorphisms Arg462Gln and Asp541Glu from the RNASEL gene (1q25), and the polymorphisms rs620861, rs1447295, rs6983267, rs7837328 from the chromosome 8q24 with the risk of presenting prostate cancer (PCa) and its clinical characteristics in a Hispanic (Chilean) population.
|
24224612 |
2014 |
|
rs13281615
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Further studies are required to confirm whether the adjacent breast cancer-associated variant rs13281615 may be inversely associated with prostate cancer risk.
|
18625567 |
2009 |
|
rs13281615
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We genotyped three variants associated with prostate cancer (rs10090154, rs13254738, and rs7000448), one associated with both prostate and colorectal cancer (rs6983267), and one associated with breast cancer (rs13281615) in a series of 1,499 breast cancer cases and 1,390 controls.
|
18349290 |
2008 |
|
rs620861
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We did not find strong evidence that associations between GWAS-identified SNPs and prostate cancer are modified by circulating concentrations of 25(OH)D. The intriguing interactions between rs620861 and rs16902094, 25(OH)D concentration, and fatal prostate cancer warrant replication.
|
28399564 |
2017 |
|
rs16901966
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The cumulative effects test of risk alleles (rs rs1983891, rs339331, rs16901966, rs1447295 and rs10090154) showed an increasing risk to PCa in a frequency-dependent manner (ptrend=0.001), and men with more than 3 risk alleles had the most significant susceptibility to PCa (OR=1.99, p=0.001), compared with those who had one risk allele (OR=1.17, p=0.486).
|
26537068 |
2016 |
|
rs16901966
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The risk alleles rs16901966, rs1447295 and rs10090154 were associated with age at diagnosis and tumor stage as compared with controls, while rs16901966 was associated with aggressive PCa (OR 1.43, 95% CI 1.01-2.03, p=0.042).
|
24377597 |
2014 |
|
rs16901966
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Four of the 14 single nucleotide polymorphisms were associated with prostate cancer risk, including rs16901966 (OR 1.343, 95% CI 1.029-1.754, p = 0.030), rs1447295 (OR 1.499, 95% CI 1.109-2.027, p = 0.008), rs11986220 (OR 1.589, 95% CI 1.160-2.178, p = 0.004) and rs10090154 (OR 1.571, 95% CI 1.146-2.154, p = 0.005).
|
22099997 |
2012 |
|
rs620861
|
|
|
0.030 |
GeneticVariation |
BEFREE |
This approach identified rs378854, which is in complete linkage disequilibrium (LD) with rs620861, as a novel functional prostate cancer-specific genetic variant.
|
21814516 |
2011 |
|
rs620861
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45).
|
19767755 |
2009 |
|
rs72725854
|
|
|
0.710 |
GeneticVariation |
BEFREE |
The 8q24 risk region was also found to be a major contributor to PCa risk in Ugandan men, with the African ancestry-specific risk variant rs72725854 estimated to account for 12% of PCa in this population.
|
29356057 |
2018 |
|
rs116041037
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Of the 82 known risk variants, 68 (83%) had effects that were directionally consistent in their association with prostate cancer risk and 30 (37%) were significantly associated with risk at p < 0.05, with the most statistically significant variants being rs116041037 (p = 3.7 × 10(-26) ) and rs6983561 (p = 1.1 × 10(-16) ) at 8q24, as well as rs7210100 (p = 5.4 × 10(-8) ) at 17q21.
|
25044450 |
2015 |
|
rs16902094
|
|
|
0.720 |
GeneticVariation |
BEFREE |
A statistically significant interaction was observed for each of 2 SNPs in the 8q24 region (rs620861 and rs16902094), 25(OH)D concentration, and fatal prostate cancer on both multiplicative and additive scales (P ≤ 0.001).
|
28399564 |
2017 |
|
rs188140481
|
|
|
0.720 |
GeneticVariation |
BEFREE |
We examined the frequency of the minor allele at rs188140481 in 4299 North American men including 1979 men with prostate cancer and 2320 healthy volunteers.
|
24952954 |
2015 |
|
rs188140481
|
|
|
0.720 |
GeneticVariation |
BEFREE |
The rs188140481 polymorphism in the 8q24 region confers a moderate increase in the risk of prostate cancer in Polish men.
|
25187206 |
2015 |
|
rs1456315
|
|
|
0.720 |
GeneticVariation |
BEFREE |
These included correlations between an intergenic CpG site at Chr8:128393157 and the prostate cancer SNP rs16902094 (ρ = -0.54; P = 9.7 × 10(-7); q = 0.002), a PRNCR1 CpG site at Chr8:128167809 and the prostate cancer SNP rs1456315 (ρ = 0.52; P = 1.4 × 10(-6); q = 0.002), and two POU5F1B CpG sites and several prostate/colorectal cancer SNPs (for Chr8:128498051 and rs6983267, ρ = 0.46; P = 2.0 × 10(-5); q = 0.01).
|
25315430 |
2014 |