|
rs16901979
|
|
|
0.800 |
GeneticVariation |
BEFREE |
SNP rs16901979 in region 2 was associated with significantly increased risk of prostate cancer (OR = 1.41, 95% confidence interval [CI] 1.02-1.95, P = 0.04) with the risk stronger in men with early-onset prostate cancer (OR = 2.37, 95% CI 1.40-3.99, P = 0.001).
|
21557270 |
2011 |
|
rs16901979
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We demonstrate that trans-acting RNA molecules facilitating resistance to androgen depletion (RAD) in vitro and castration-resistant phenotype (CRP) in vivo of PC contain intergenic 8q24-locus SNP variants (rs1447295; rs16901979; rs6983267) that were recently linked with increased risk of PC.
|
22067658 |
2011 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
There was a tendency towards significantly increased risk for SNPs rs1447295 and rs6983267 in men with early-onset prostate cancer.
|
21557270 |
2011 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
A highly significant association (odds ratio=2.84 and p-value=0.002) was found between rs6983267 and prostate cancer in the Greek population.
|
22070222 |
2011 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We demonstrate that trans-acting RNA molecules facilitating resistance to androgen depletion (RAD) in vitro and castration-resistant phenotype (CRP) in vivo of PC contain intergenic 8q24-locus SNP variants (rs1447295; rs16901979; rs6983267) that were recently linked with increased risk of PC.
|
22067658 |
2011 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Correlation between genotypes and biopsy outcome (positive or negative) and Gleason score (≤6 or >6) were studied by univariate and multivariable analysis. rs1447295 and rs6983267 risk variants were found to be associated with the presence of PCa in univariate analysis. rs6983267 genotype remained significantly linked to a positive biopsy (odds ratio [OR] = 1.66, 95% confidence interval [CI]: 1.06-2.59, P = 0.026) in multivariable analysis, but rs1447295 genotype did not (OR = 1.47, 95% CI: 0.89-2.43, P = 0.13).When biopsy outcome was stratified according to Gleason score, risk variants of rs1447295 were associated with aggressive disease (Gleason score ≥7) in univariate and multivariable analysis (OR = 2.05 95% CI: 1.10-3.79, P = 0.023). rs6983267 GG genotype was not related to aggressiveness.
|
21308149 |
2011 |
|
rs16901979
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The variants rs16901979 and rs6983561 at 8q24 are associated with prostate cancer risk in Taiwanese men.
|
19908238 |
2010 |
|
rs16901979
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Forty-nine tagging SNPs including three previously reported significant variants (rs1447295, rs6983267, rs16901979) and seven variants in the 5' upstream region of the MYC proto-oncogene were tested for association with susceptibility to PC and tumor aggressiveness in 596 histologically verified PC cases and 567 ethnically matched controls.
|
19562729 |
2009 |
|
rs16901979
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Two of these 17 SNPs, located at 3p12, and region 2 at 8q24, were significantly associated with prostate cancer risk (P < 0.05), and only SNP rs16901979 at region 2 of 8q24 remained significant after accounting for 20 tests.
|
19549807 |
2009 |
|
rs16901979
|
|
A |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility.
|
19767754 |
2009 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism (SNP) rs6983267, located within the 8q24 region, is strongly associated with risk of colorectal and prostate cancer.
|
19895682 |
2009 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The A allele of rs1447295 was significantly associated with the risk of sporadic prostate cancer (p = 0.04; age-adjusted OR, 1.34), while the G allele of rs6983267 showed a trend towards being a high-risk allele (p = 0.06; age-adjusted OR, 1.27).
|
19602258 |
2009 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The highest significance in Caucasian men was found for rs6983267; the AA genotype reduced the risk for PCa [odds ratio (OR) = 0.48, 95% confidence interval (CI) = 0.35-0.65, P = 2.74 x 10(-6)].
|
19528667 |
2009 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Forty-nine tagging SNPs including three previously reported significant variants (rs1447295, rs6983267, rs16901979) and seven variants in the 5' upstream region of the MYC proto-oncogene were tested for association with susceptibility to PC and tumor aggressiveness in 596 histologically verified PC cases and 567 ethnically matched controls.
|
19562729 |
2009 |
|
rs16901979
|
|
|
0.800 |
GeneticVariation |
BEFREE |
There was no joint effect between SNPs rs16901979 A and rs6983267 G. These results confirm the significance of these SNPs in prostate cancer etiology in a previously unstudied population who do not undergo prostate cancer screening and are diagnosed with severe disease.
|
18768513 |
2008 |
|
rs16901979
|
|
|
0.800 |
GeneticVariation |
BEFREE |
A meta-analysis across 10 studies including our results of four 8q24 variants (rs1442295 and DG8S737-region 1, rs16901979-region 2, and rs6983267-region 3) and prostate cancer risk demonstrated strong associations across a wide array of study designs and populations.
|
18231127 |
2008 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs6983267 G allele did not show significant association with susceptibility to PC (PC vs. non-PC: P = 0.967; OR, 1.00; 95%CI = 0.83-1.21).
|
18726982 |
2008 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
A meta-analysis across 10 studies including our results of four 8q24 variants (rs1442295 and DG8S737-region 1, rs16901979-region 2, and rs6983267-region 3) and prostate cancer risk demonstrated strong associations across a wide array of study designs and populations.
|
18231127 |
2008 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms (SNPs) rs6983561 and rs6983267 showed the strongest evidence of prostate cancer association.
|
18360876 |
2008 |
|
rs6983267
|
|
G |
0.800 |
GeneticVariation |
GWASCAT |
Multiple loci identified in a genome-wide association study of prostate cancer.
|
18264096 |
2008 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
One marker, rs6983267 on chromosome 8q24, has been linked to both colon and prostate cancer, and is therefore a good candidate for a multicancer susceptibility marker.
|
19047180 |
2008 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We genotyped three variants associated with prostate cancer (rs10090154, rs13254738, and rs7000448), one associated with both prostate and colorectal cancer (rs6983267), and one associated with breast cancer (rs13281615) in a series of 1,499 breast cancer cases and 1,390 controls.
|
18349290 |
2008 |
|
rs6983267
|
|
G |
0.800 |
GeneticVariation |
GWASCAT |
Multiple newly identified loci associated with prostate cancer susceptibility.
|
18264097 |
2008 |
|
rs6983267
|
|
|
0.800 |
GeneticVariation |
BEFREE |
There was no joint effect between SNPs rs16901979 A and rs6983267 G. These results confirm the significance of these SNPs in prostate cancer etiology in a previously unstudied population who do not undergo prostate cancer screening and are diagnosed with severe disease.
|
18768513 |
2008 |
|
rs16901979
|
|
A |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.
|
17401366 |
2007 |