|
rs10017134
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant association with EOC was identified in the UGT2A1/2 region for the SNP rs10017134 (per allele OR = 1.4, 95% CI = 1.2-1.7, P = 1.2 × 10<sup>-6</sup> , BFDP = 0.02); and an association with HGSOC was identified in the EGFR region for the SNP rs114972508 (per allele OR = 2.3, 95% CI = 1.6-3.4, P = 1.6 × 10<sup>-5</sup> , BFDP = 0.29) and in the UGT2A1/2 region again for rs1017134 (per allele OR = 1.4, 95% CI = 1.2-1.7, P = 2.3 × 10<sup>-5</sup> , BFDP = 0.23).
|
31001917 |
2019 |
|
rs1002076
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the rs17401966 variant AG/GG genotypes were significantly associated with a decreased risk of EOC (adjusted odds ratio (OR) = 0.81, 95 % confidence interval (CI) = 0.68-0.97), compared with the AA genotype, but no associations were observed for rs1002076.
|
25854172 |
2015 |
|
rs10069690
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Identification of six new susceptibility loci for invasive epithelial ovarian cancer.
|
25581431 |
2015 |
|
rs10088218
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Identification of six new susceptibility loci for invasive epithelial ovarian cancer.
|
25581431 |
2015 |
|
rs1017134
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant association with EOC was identified in the UGT2A1/2 region for the SNP rs10017134 (per allele OR = 1.4, 95% CI = 1.2-1.7, P = 1.2 × 10<sup>-6</sup> , BFDP = 0.02); and an association with HGSOC was identified in the EGFR region for the SNP rs114972508 (per allele OR = 2.3, 95% CI = 1.6-3.4, P = 1.6 × 10<sup>-5</sup> , BFDP = 0.29) and in the UGT2A1/2 region again for rs1017134 (per allele OR = 1.4, 95% CI = 1.2-1.7, P = 2.3 × 10<sup>-5</sup> , BFDP = 0.23).
|
31001917 |
2019 |
|
rs10260419
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall EOC risk was associated with rs10260419 at chromosome 7p21.3 (OR = 1.33, P = 1.2 × 10<sup>-7</sup>) and rs74917072 at chromosome 2q37.3 (OR = 1.25, P = 4.7 × 10<sup>-7</sup>).
|
30898391 |
2019 |
|
rs1045642
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study represents the largest analysis of ABCB1 SNPs and EOC progression and survival to date, but has not identified additional signals, or validated reported associations with progression-free survival for rs1128503, rs2032582, and rs1045642.
|
23917080 |
2013 |
|
rs104886003
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1052133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Germ line variants in 5'-untranslated region (c.-18G>T, c.-23A>G, c.-45G>A, and c.-53G>C) and c.977C>G (Ser326Cys) polymorphism in exon7 of the hOGG1 gene in 420 sporadic EOCs and 840 controls were detected.
|
21997177 |
2011 |
|
rs1057156
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that RUVBL1 rs1057156 A>G and RUVBL1 rs149652370 A>G were associated with survival of EOC patients in the multivariate Cox proportional hazards regression analysis.
|
31083717 |
2019 |
|
rs10788679
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Other variants of interest included another in ARHGEF10L, rs10788679, which was associated with invasive serous EOC risk (OR = 1.07, p = 0.00026) and two variants in AKAP6 (A-kinase anchoring protein 6) which were associated with risk of invasive EOC (rs1955513, OR = 0.90, p = 0.00033; rs927062, OR = 0.94, p = 0.00059).
|
29979793 |
2018 |
|
rs11175194
|
|
G |
0.710 |
GeneticVariation |
GWASCAT |
Finally, we identify two EOC susceptibility loci at 9q22.33 (rs1413299 in COL15A1, P(meta) = 1.88 × 10(-8)) and 10p11.21 (rs1192691 near ANKRD30A, P(meta) = 2.62 × 10(-8)), and two consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, P(meta) = 1.14 × 10(-7)) and 9q34.2 (rs633862 near ABO and SURF6, P(meta) = 8.57 × 10(-7)) (P<0.05 in all three stages).
|
25134534 |
2014 |
|
rs11175194
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Finally, we identify two EOC susceptibility loci at 9q22.33 (rs1413299 in COL15A1, P(meta) = 1.88 × 10(-8)) and 10p11.21 (rs1192691 near ANKRD30A, P(meta) = 2.62 × 10(-8)), and two consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, P(meta) = 1.14 × 10(-7)) and 9q34.2 (rs633862 near ABO and SURF6, P(meta) = 8.57 × 10(-7)) (P<0.05 in all three stages).
|
25134534 |
2014 |
|
rs1128503
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study represents the largest analysis of ABCB1 SNPs and EOC progression and survival to date, but has not identified additional signals, or validated reported associations with progression-free survival for rs1128503, rs2032582, and rs1045642.
|
23917080 |
2013 |
|
rs113488022
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A patient with V600E BRAF-mutant melanoma and another with platinum-refractory epithelial ovarian cancer exhibiting PTEN loss and PIK3CA amplification demonstrated partial response by RECIST and GCIG-CA125 criteria, respectively.
|
25370471 |
2015 |
|
rs114972508
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant association with EOC was identified in the UGT2A1/2 region for the SNP rs10017134 (per allele OR = 1.4, 95% CI = 1.2-1.7, P = 1.2 × 10<sup>-6</sup> , BFDP = 0.02); and an association with HGSOC was identified in the EGFR region for the SNP rs114972508 (per allele OR = 2.3, 95% CI = 1.6-3.4, P = 1.6 × 10<sup>-5</sup> , BFDP = 0.29) and in the UGT2A1/2 region again for rs1017134 (per allele OR = 1.4, 95% CI = 1.2-1.7, P = 2.3 × 10<sup>-5</sup> , BFDP = 0.23).
|
31001917 |
2019 |
|
rs115344852
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Identification of six new susceptibility loci for invasive epithelial ovarian cancer.
|
25581431 |
2015 |
|
rs11651755
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Different single-nucleotide polymorphisms associate with invasive serous (rs7405776 odds ratio (OR)=1.13, P=3.1 × 10(-10)) and clear cell (rs11651755 OR=0.77, P=1.6 × 10(-8)) epithelial ovarian cancer.
|
23535649 |
2013 |
|
rs11696662
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Other associations of note included TNF receptor-associated factor 2 (TRAF2) rs17250239 in patients with high-grade serous EOC (HR, 0.84; 95% CI, 0.77-0.92; P = 6.49 × 10(-5)) and phospholipase C, gamma 1 (PLCG1) rs11696662 in patients with clear cell EOC (HR, 0.43; 95% CI, 0.26-0.73; P = 4.56 × 10(-4)).
|
24740199 |
2014 |
|
rs11782652
|
|
G |
0.710 |
GeneticVariation |
GWASCAT |
Identification of six new susceptibility loci for invasive epithelial ovarian cancer.
|
25581431 |
2015 |
|
rs11782652
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We validated the two loci at 3q25 and 17q21 that were previously found to have associations close to genome-wide significance and identified three loci newly associated with risk: two loci associated with all EOC subtypes at 8q21 (rs11782652, P = 5.5 × 10(-9)) and 10p12 (rs1243180, P = 1.8 × 10(-8)) and another locus specific to the serous subtype at 17q12 (rs757210, P = 8.1 × 10(-10)).
|
23535730 |
2013 |
|
rs1192691
|
|
C |
0.710 |
GeneticVariation |
GWASCAT |
Finally, we identify two EOC susceptibility loci at 9q22.33 (rs1413299 in COL15A1, P(meta) = 1.88 × 10(-8)) and 10p11.21 (rs1192691 near ANKRD30A, P(meta) = 2.62 × 10(-8)), and two consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, P(meta) = 1.14 × 10(-7)) and 9q34.2 (rs633862 near ABO and SURF6, P(meta) = 8.57 × 10(-7)) (P<0.05 in all three stages).
|
25134534 |
2014 |
|
rs1192691
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Finally, we identify two EOC susceptibility loci at 9q22.33 (rs1413299 in COL15A1, P(meta) = 1.88 × 10(-8)) and 10p11.21 (rs1192691 near ANKRD30A, P(meta) = 2.62 × 10(-8)), and two consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, P(meta) = 1.14 × 10(-7)) and 9q34.2 (rs633862 near ABO and SURF6, P(meta) = 8.57 × 10(-7)) (P<0.05 in all three stages).
|
25134534 |
2014 |
|
rs12039431
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Identification of six new susceptibility loci for invasive epithelial ovarian cancer.
|
25581431 |
2015 |
|
rs121913279
|
|
G |
0.700 |
CausalMutation |
CLINVAR |
|
|
|