rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No modifying effect of A1298C genotypes on the association of folate intake with breast cancer risk was observed.
|
14973091 |
2004 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The MTHFR C677T and A1298C polymorphisms are likely to play an important role in the susceptibility to br</span>east cancer.
|
15004488 |
2004 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated independent and joint effects of B vitamin intake as well as two polymorphisms of a key one-carbon metabolizing gene [i.e., methylenetetrahydrofolate reductase (MTHFR) 677C>T and 1298A>C] on breast cancer risk.
|
15735051 |
2005 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A meta-analysis of 18 case-control studies investigating the association between the C677T and the A1298C polymorphisms of the MTHFR gene and breast cancer (BC) was carried out.
|
16630166 |
2006 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To evaluate the C677T and A1298C functional polymorphisms in the MTHFR gene and their associations with breast cancer risk, as well as the potential modifying effect by plasma folate status on the MTHFR-associated risk, a hospital-based case-control study was conducted on a Taiwanese population consisting of 146 histologically confirmed incident breast cancer cases and their 285 age-matched controls without a history of cancer.
|
16777985 |
2006 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that the MTHFR SNPs, C677T and A1298C, were associated with breast cancer survival.
|
17069650 |
2006 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Based on the hypothesis that variants of the cSHMT C1420T together with methionine synthase (MS A2756G) and 5,10-methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) are associated with breast cancer, we performed a multigenic case-control study of the effects to breast cancer risk of four polymorphisms of folate-metabolizing genes against duration of estrogen exposure.
|
17896178 |
2008 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In a nested case-control study of 380 women with incident breast cancer and 662 controls within the Singapore Chinese Health Study, we found no association between either green tea intake or gene polymorphisms of MTHFR (C677T and A1298C) and TYMS (1494 ins/del) and breast cancer risk.
|
18669903 |
2008 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Viable cell growth, MDI, and polymorphism frequency in MTRR (A66G and C524T) and MTHFR (A1298C and A1793G) did not differ among the study groups; however, MDI tended to be higher in BRCA carriers with breast cancer than those without and was significantly increased in MTHFR 677T allele carriers relative to wild-type carriers (P=0.017).
|
18842997 |
2008 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We examined if the association between tertiles of dietary folate equivalents (DFE) and breast cancer was different in subgroups according to genotypes of the MTHFR 677 C>T (rs1801133) and 1298A>C (rs1801131) SNPs and if the polymorphisms per se were associated with breast cancer.
|
19336565 |
2009 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
With respect to A1298C polymorphism, no significant association with breast cancer risk was demonstrated in overall, ethnicity- and menopausal status-based population.
|
20135343 |
2010 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Overall, no significant associations were found between MTHFR A1</span>298C polymorphism and breast cancer risk when all studies pooled into the meta-analysis (AC vs. AA: OR=0.99, 95% CI 0.94-1.05; CC vs. AA: OR 0.99, 95% CI 0.90-1.09; dominant model: OR=0.99, 95% CI 0.95-1.04; and recessive model: OR=0.98, 95% CI 0.90-1.08).
|
21052845 |
2011 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We investigated the independent and the combined effects of two commonly occurring polymorphisms, MTHFR 677C>T (rs1801133) and MTHFR 1298A>C (rs1801131), as well as their interaction with the use of hormone replacement therapy (HRT), to determine their potential contribution to breast cancer risk.
|
21461582 |
2011 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We examined the association of two common MTHFR polymorphisms (C677T and A1298C) and their haplotypes in a candidate-gene association study, involving 300 female patients with BC and 283 healthy women.
|
21875371 |
2012 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this case-control study, we investigated the association between MTHFR C677T and A1298C, TYMS 5'-UTR, MTR A2756G and cSHMT C1420T and also the folate carrier (RFC1 G80A) and breast cancer risk in a northeastern Brazilian population.
|
22134752 |
2012 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Associations between the combined MTHFR C677T-A1298C polymorphism and breast cancer are possible from this study.
|
22901194 |
2012 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study points out the importance of the interactions between the MTHFR C677T, MTHFR A1298C and MTR A2756G polymorphisms, and also highlights the relevance of the MTR A2756G polymorphism and age in breast cancer risk.
|
23155246 |
2012 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present data suggest that germ-line polymorphisms of C677T, C1298A for MTHFR and R2 for FV are associated in breast cancer and may be additional prognostic markers related to breast cancer survival.
|
23803051 |
2013 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The MTHFR A1298C genotype was associated with a decreased risk of BC [OR=0.68; 95% CI: 0.49-0.95].
|
24023349 |
2013 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no significant association found between A1298C polymorphism and breast cancer risk under all genetic models (C vs. A: OR = 0.96, 95 % CI = 0.89-1.03, P = 0.268; CC vs. AA: OR = 0.98, 95 % CI = 0.77-1.26, P = 0.899; AC vs. AA: OR = 0.95, 95 % CI = 0.88-1.02, P = 0.174; CC vs. AC/AA: OR = 1.00, 95 % CI = 0.78-1.28, P = 0.996, CC/AC vs. AA: OR = 0.96, 95 % CI = 0.89-1.02, P = 0.196).
|
24078451 |
2014 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Folate intake, vitamin B12 intake and variants of MTHFR C677T and MTHFR A1298C demonstrated no association with risk of breast cancer.
|
24175799 |
2013 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, the 1298 A>C polymorphism is not significantly associated with increased risks of breast cancer.
|
24945727 |
2014 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The findings suggest that the MTHFR C677T polymorphism but not A1298C, and some variants on their combined genotypes or haplotypes may be involved with the development of breast cancer.
|
24973876 |
2014 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two well-known polymorphic variants of MTHFR, C677T (rs1801133) and A1298C (rs1801131), were analyzed and their joint effects with individual age- and estrogen-related factors on breast cancer risk were discussed.
|
25075036 |
2014 |
rs397507444
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conducted a hospital-based case-control study to investigate the associations of dietary intake of folate and MTHFR C677T and A1298C polymorphisms with breast cancer in a Chinese population.
|
25078601 |
2014 |