|
rs920778
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The association between the expression of rs920778 and BC, CC, and OC susceptibility was not clear (alleles T/C: OR = 1.28 [95% CI, 0.87-1.89]; in codominant model: CT/CC OR = 1.10, [95% CI, 0.71-1.71], TT/CC OR = 1.29 [95% CI, 0.59-2.80]; dominant model: TC + TT/CC OR = 1.16, [95% CI, 0.73-1.86]; and recessive model: TT/TC + CC OR = 1.43, [95% CI, 0.83-2.47]).
|
30484890 |
2018 |
|
rs920778
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our findings indicated that rs920778 polymorphism has significant positive association with breast cancer; rs12826786 and rs1899663 polymorphisms demonstrated significant negative association with breast cancer; and the rs4759314 variant was not associated with breast cancer risk.
|
29022495 |
2017 |
|
rs920778
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Because our findings suggest for the first time that the CC genotype of HOTAIR rs920778 polymorphism might play important roles in genetic susceptibility to BC development and aggressiveness in a Turkish population, further independent studies are required to validate our findings in a larger series, as well as in patients of different populations.
|
25586347 |
2015 |
|
rs920778
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In conclusion, genetic variant rs920778 in HOTAIR significantly increased the risk of BC, and it may have apparent interaction with reproductive factors in the progression on BC.
|
26547792 |
2015 |
|
rs1899663
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Multivariate analyses also revealed the rs1899663 TT genotype and rs7958904 CC genotype were both at higher risk of breast cancer compared with the GG homozygotes (OR = 2.08, 95% CI = 1.20-3.60 and OR = 1.45, 95% CI = 1.01-2.08, respectively).
|
29423075 |
2018 |
|
rs1899663
|
|
|
0.030 |
GeneticVariation |
BEFREE |
HOTAIR polymorphism rs1899663 was associated with BC, CC, and OC susceptibility to a certain extent, (alleles T/G OR = 0.90 [95% CI, 0.69-1.16]; in the codominant model: GT/GG OR = 0.81 [95% CI, 0.50-1.30], TT/GG OR = 1.04 [95% CI, 0.63-1.72]; dominant model: GT + TT/GG OR = 0.82 [95% CI, 0.52-1.29]; and recessive model: TT/GT + GG OR = 1.21 [95% CI, 0.76-1.94]).
|
30484890 |
2018 |
|
rs4759314
|
|
|
0.030 |
GeneticVariation |
BEFREE |
HOTAIR rs4759314 increased susceptibility to BC, CC, and OC in some patients; rs029778 and rs1899663 also increased susceptibility to some extent.
|
30484890 |
2018 |
|
rs4759314
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In this case-control study, we assessed the interaction between three lncRNA HOTAIR single nucleotide polymorphisms (SNPs) (rs1899663, rs4759314 and rs7958904) on the risk and clinical outcome of breast cancer in a Chinese Han population.
|
29423075 |
2018 |
|
rs1899663
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, we investigated only four variants of HOX transcript antisense intergenic RNA gene, and the findings suggest that HOX transcript antisense intergenic RNA rs920778, rs12826786, and rs1899663 polymorphisms may be associated with breast cancer risk in a sample of southeast Iranian population.
|
29022495 |
2017 |
|
rs4759314
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our findings indicated that rs920778 polymorphism has significant positive association with breast cancer; rs12826786 and rs1899663 polymorphisms demonstrated significant negative association with breast cancer; and the rs4759314 variant was not associated with breast cancer risk.
|
29022495 |
2017 |
|
rs7958904
|
|
|
0.020 |
GeneticVariation |
BEFREE |
SNPs rs12826786, rs7958904, and rs874945 did not correlate with an effect on patient susceptibility to BC, CC, and OC.
|
30484890 |
2018 |
|
rs7958904
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Multivariate analyses also revealed the rs1899663 TT genotype and rs7958904 CC genotype were both at higher risk of breast cancer compared with the GG homozygotes (OR = 2.08, 95% CI = 1.20-3.60 and OR = 1.45, 95% CI = 1.01-2.08, respectively).
|
29423075 |
2018 |