|
rs1042838
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Patients carrying rs1042838 G/T, rs590688 C/C, and rs10895068 G/A genotypes had higher risk of breast cancer, while carriage of rs3740753 G/G genotype was associated with marginal reduction in breast cancer risk.
|
29302853 |
2020 |
|
rs1042838
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We did not observe an association between potential functional genetic polymorphisms in the estrogen pathway, SHBG rs6259, ESR1 rs2234693, CYP19 rs10046 and rs4775936, and UGT1A1 rs8175347, or the progesterone pathway, PGR rs1042838, with the risk of breast cancer.
|
23935996 |
2013 |
|
rs1042838
|
|
|
0.060 |
GeneticVariation |
BEFREE |
We conclude that the leucine allele of the V660L SNP may be associated with a small increase in breast cancer risk, while the other four PGR SNPs, +44C/T (rs518162), +331G/A (rs10895068), H770H (rs1042839) and Q886Q (rs500760), do not substantially increase breast cancer risk.
|
17592773 |
2008 |
|
rs1042838
|
|
|
0.060 |
GeneticVariation |
BEFREE |
After both stages, only one SNP was significantly associated with an increased risk of breast cancer - the PGR-12 (rs1042638) V660L valine to leucine polymorphism [VL heterozygotes (odds ratio, 1.13; 95% confidence interval, 1.03-1.24) and the LL homozygotes (odds ratio, 1.30; 95% confidence interval, 0.98-1.73), P(het) = 0.008, P(trend) = 0.002].
|
16614108 |
2006 |
|
rs1042838
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Overall, our study does not support an association between the Val660-->Leu PROGINS polymorphism and breast cancer risk.
|
15535845 |
2004 |
|
rs1042838
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The progesterone receptor exon 4 Val660Leu G/T polymorphism and risk of breast cancer in Australian women.
|
12010857 |
2002 |
|
rs10895068
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Furthermore, carriage of rs10895068</span> minor allele in breast cancer women were also associated with age at first pregnancy, hormone receptor (RH) status, and previous use of oral contraceptives.
|
29302853 |
2020 |
|
rs10895068
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Many published studies have estimated the association between the +331G/A (rs10895068) polymorphism in the progesterone receptor (PgR) gene and breast cancer risk.
|
29084518 |
2017 |
|
rs10895068
|
|
|
0.040 |
GeneticVariation |
BEFREE |
To date, many studies have evaluated the association between a functional polymorphism in the PgR gene promoter (+331G>A, rs10895068) and breast cancer risk; however, the result is still ambiguous and inconclusive.
|
20076999 |
2010 |
|
rs10895068
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We conclude that the leucine allele of the V660L SNP may be associated with a small increase in breast cancer risk, while the other four PGR SNPs, +44C/T (rs518162), +331G/A (rs10895068), H770H (rs1042839) and Q886Q (rs500760), do not substantially increase breast cancer risk.
|
17592773 |
2008 |
|
rs590688
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Two haplotypes, ATGCCGA and GTGCCGA, both containing rs590688, were positively associated with breast cancer, thus assigning a breast cancer-susceptible nature to these haplotypes.
|
29302853 |
2020 |
|
rs590688
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Three haplotype blocks, all containing rs590688, were found to be significantly associated with breast cancer risk.
|
23764995 |
2013 |
|
rs3740753
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patients carrying rs1042838 G/T, rs590688 C/C, and rs10895068 G/A genotypes had higher risk of breast cancer, while carriage of rs3740753 G/G genotype was associated with marginal reduction in breast cancer risk.
|
29302853 |
2020 |
|
rs1312187959
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to elucidate the possible correlation between UGT1A1*6, a single nucleotide polymorphism causing a Gly71Arg substitution, and breast cancer susceptibility.
|
27525948 |
2016 |
|
rs1408080623
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that the OATP1B1 T521C mutation may be an independent prognostic marker for breast cancer patients using TAM therapy.
|
25701109 |
2015 |
|
rs10895054
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For rs10895054, each addition of the T allele increased the risk of breast cancer compared to the A allele nearly threefold (OR = 2.9, 95 % CI 1.47-6.02, p value 0.002, corrected p value 0.04).
|
23764995 |
2013 |
|
rs1042839
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conclude that the leucine allele of the V660L SNP may be associated with a small increase in breast cancer risk, while the other four PGR SNPs, +44C/T (rs518162), +331G/A (rs10895068), H770H (rs1042839) and Q886Q (rs500760), do not substantially increase breast cancer risk.
|
17592773 |
2008 |
|
rs500760
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conclude that the leucine allele of the V660L SNP may be associated with a small increase in breast cancer risk, while the other four PGR SNPs, +44C/T (rs518162), +331G/A (rs10895068), H770H (rs1042839) and Q886Q (rs500760), do not substantially increase breast cancer risk.
|
17592773 |
2008 |
|
rs518162
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conclude that the leucine allele of the V660L SNP may be associated with a small increase in breast cancer risk, while the other four PGR SNPs, +44C/T (rs518162), +331G/A (rs10895068), H770H (rs1042839) and Q886Q (rs500760), do not substantially increase breast cancer risk.
|
17592773 |
2008 |
|
rs11571149
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer.
|
17028982 |
2007 |
|
rs772873062
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR=1.81, 95% CI=1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk (adjusted OR=0.74, 95% CI=0.56-0.99).
|
17028982 |
2007 |
|
rs750042441
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, we found a significant gene-gene interaction between P53BP1 Gln1136Lys and p53 Arg72Pro variants in relation to breast cancer, and the OR of interaction for the presence of both P53BP1 1136Gln/Lys+Lys/Lys and p53 72Arg/Pro+Pro/Pro genotypes was 1.93 (95% CI 1.06-3.52) (P=0.031 for interaction).
|
16314399 |
2006 |
|
rs757679709
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For five SNPs--CASP8 D302H, IGFBP3 -202 c>a, PGR V660L, SOD2 V16A, and TGFB1 L10P--the associations with breast cancer were of borderline statistical significance (P = .016, .060, .047, .056, and .0088 respectively).
|
17018785 |
2006 |
|
rs776880789
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no statistical difference in the C1qA[276A/G] allelic distribution between all subjects with breast cancer and controls.
|
16465510 |
2006 |
|
rs376101426
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study provides little evidence that variation in Val-9Ala polymorphism of MnSOD alone or through substantial interaction with key exposures believed to be pro- or anti-oxidant properties influences breast cancer risk.
|
16215873 |
2005 |