|
rs11075995
|
|
|
0.720 |
GeneticVariation |
BEFREE |
However, <i>FTO</i> rs11075995 variant risk allele was associated with breast cancer risk without adjustment for body mass index, but the association disappeared with further adjustment for body mass index.
|
28881622 |
2017 |
|
rs11075995
|
|
A |
0.720 |
GeneticVariation |
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
|
rs17817449
|
|
T |
0.720 |
GeneticVariation |
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
|
rs17817449
|
|
|
0.720 |
GeneticVariation |
GWASCAT |
Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer.
|
27117709 |
2016 |
|
rs11075995
|
|
A |
0.720 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
|
25751625 |
2015 |
|
rs17817449
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Of 41 recently discovered breast cancer susceptibility variants, associations were found between rs1432679 (EBF1), rs17817449 (MIR1972-2: FTO), rs12710696 (2p24.1), and rs3757318 (ESR1) and adjusted absolute and percent dense areas, respectively.
|
25862352 |
2015 |
|
rs17817449
|
|
T |
0.720 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
|
25751625 |
2015 |
|
rs11075995
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Of the four breast cancer subtypes, the associations of rs12493607 (3p24.1/TGFBR2) with HER-2 overexpression in breast cancer (P = 1.09 × 10(-3)) and rs11075995 (16q12.2/FTO) with basal-like breast cancer (P = 1.64 × 10(-4)) were statistically significant.
|
25007960 |
2014 |
|
rs11075995
|
|
|
0.720 |
GeneticVariation |
GWASCAT |
Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
|
23535733 |
2013 |
|
rs17817449
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Seven SNPs were statistically significant (P ≤ 0.05) with the risk of overall breast cancer in the same direction as previously reported: rs10069690 (5p15/TERT), rs999737 (14q24/RAD51L1), rs13387042 (2q35/TNP1), rs1219648 (10q26/FGFR2), rs8170 (19p13/BABAM1), rs17817449 (16q12/FTO), and rs13329835 (16q23/DYL2).
|
23593120 |
2013 |
|
rs17817449
|
|
T |
0.720 |
GeneticVariation |
GWASCAT |
Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
|
23535733 |
2013 |
|
rs17817449
|
|
T |
0.720 |
GeneticVariation |
GWASCAT |
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
|
23535729 |
2013 |
|
rs56077980
|
|
CT |
0.700 |
GeneticVariation |
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
|
rs62048402
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
|
rs9939609
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Lack of Association of the Fat Mass and Obesity Associated (FTO) Gene rs9939609 Polymorphism with Breast Cancer Risk: a Systematic Review and Meta-Analysis Based on Case - Control Studies
|
28547937 |
2017 |
|
rs9939609
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Three T2D associated risk variants were individually associated with breast cancer risk after adjustment for multiple comparisons using the Bonferroni method (at p < 0.001), rs9939609 (FTO) (OR 0.94, 95 % CI = 0.92-0.95, p = 4.13E-13), rs7903146 (TCF7L2) (OR 1.04, 95 % CI = 1.02-1.06, p = 1.26E-05), and rs8042680 (PRC1) (OR 0.97, 95 % CI = 0.95-0.99, p = 8.05E-04).
|
27053251 |
2016 |
|
rs9939609
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Haplotype analysis showed that FTO TAC haplotype (rs9939609-rs1477196-rs1121980) had significant reduced breast cancer risk (OR = 0.76, 95% CI: 0.62-0.93) compared with TGC haplotype.
|
26146447 |
2015 |
|
rs9939609
|
|
|
0.040 |
GeneticVariation |
BEFREE |
When analyzed alone, FTO rs1121980 and rs9939609 did not show significant associations with BC development, however MC4R rs17782313 showed increased risk for BC even after adjustments (P-value = 0.032).
|
24091943 |
2013 |
|
rs1477196
|
|
|
0.030 |
GeneticVariation |
BEFREE |
FTO rs1477196 AA genotype had significant decreased breast cancer</span> risk [odds ratio (OR) = 0.54, 95% confidence interval (CI): 0.34-0.86] compared to GG genotype, and this association was only found in women with BMI < 24 kg/m(2) (OR = 0.41, 95% CI: 0.22-0.76); and rs16953002 AA genotype conferred significant increased breast cancer risk (OR = 1.80, 95% CI: 1.23-2.63) compared to GG genotype.
|
26146447 |
2015 |
|
rs1477196
|
|
|
0.030 |
GeneticVariation |
BEFREE |
To analyze associations between homocysteine level, MTHFR and FTO rs1477196 polymorphisms and folate status in patients with breast cancer (BC) in order to clarify determinants of hyperhomocysteinemia.
|
24023349 |
2013 |
|
rs1477196
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We found that all SNPs were significantly associated with breast cancer risk with rs1477196 showing the strongest association.
|
21489227 |
2011 |
|
rs1121980
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Haplotype analysis showed that FTO TAC haplotype (rs9939609-rs1477196-rs1121980) had significant reduced breast cancer risk (OR = 0.76, 95% CI: 0.62-0.93) compared with TGC haplotype.
|
26146447 |
2015 |
|
rs1121980
|
|
|
0.020 |
GeneticVariation |
BEFREE |
When analyzed alone, FTO rs1121980 and rs9939609 did not show significant associations with BC development, however MC4R rs17782313 showed increased risk for BC even after adjustments (P-value = 0.032).
|
24091943 |
2013 |
|
rs16953002
|
|
|
0.010 |
GeneticVariation |
BEFREE |
FTO rs1477196 AA genotype had significant decreased breast cancer risk [odds ratio (OR) = 0.54, 95% confidence interval (CI): 0.34-0.86] compared to GG genotype, and this association was only found in women with BMI < 24 kg/m(2) (OR = 0.41, 95% CI: 0.22-0.76); and rs16953002 AA genotype conferred significant increased breast cancer risk (OR = 1.80, 95% CI: 1.23-2.63) compared to GG genotype.
|
26146447 |
2015 |