|
rs20417
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Here, we evaluate the impact of the four most common cyclooxygenase-2 gene polymorphisms (rs689465, rs689466, rs20417 and rs20417), in combination with obesity, on the risk of breast cancer progression in a cohort of Brazilian breast cancer patients (<i>N</i> = 1038).
|
29321183 |
2018 |
|
rs20417
|
|
|
0.050 |
GeneticVariation |
BEFREE |
COX-2-rs20417 CC genotype was significantly associated with increased risk of breast cancer when comparing to G allele [ORs were 1.231 (1.050-1.444) for CC vs. GG, P = 0.01, 1.223 (1.045-1.432) for CC vs. G carrier, P = 0.01].
|
25433948 |
2015 |
|
rs20417
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Our results indicate no strong association between three most frequent COX-2 SNPs rs689465 rs689466, rs20417 studied with breast cancer risk in the single locus analysis.
|
24789723 |
2015 |
|
rs20417
|
|
|
0.050 |
GeneticVariation |
BEFREE |
This meta-analysis showed that COX-2 rs20417 polymorphism was correlated with an increased risk of breast cancer in Caucasians, while rs689466 was associated with a decreased risk of breast cancer in Caucasians.
|
25214704 |
2014 |
|
rs20417
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In conclusion, the present meta-analysis suggests that none of the most studied three SNPs (rs5275, rs20417, and rs5277) in the COX-2 gene is a conspicuous low-penetrant risk factor for developing breast cancer.
|
20033767 |
2010 |
|
rs689466
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Here, we evaluate the impact of the four most common cyclooxygenase-2 gene polymorphisms (rs689465, rs689466, rs20417 and rs20417), in combination with obesity, on the risk of breast cancer progression in a cohort of Brazilian breast cancer patients (<i>N</i> = 1038).
|
29321183 |
2018 |
|
rs689466
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In this case-control study, three sequence variants rs689465, rs689466, rs20417 in the promoter region of COX-2 were screened to evaluate the association with breast cancer risk.
|
24789723 |
2015 |
|
rs689466
|
|
|
0.040 |
GeneticVariation |
BEFREE |
In contrast, COX-2 rs5275, rs689466, rs2206593 and rs5277 polymorphisms might be not associated with the risk of breast cancer.
|
25433948 |
2015 |
|
rs5275
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The rs5275 polymorphism had no association with breast cancer risk.
|
25214704 |
2014 |
|
rs5275
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Associations between the 8473T>C polymorphism (rs5275) in the cyclooxygenase-2 (COX-2) gene and breast cancer (BC) risk are still inconclusive and ambiguous.
|
25520090 |
2014 |
|
rs689466
|
|
|
0.040 |
GeneticVariation |
BEFREE |
This meta-analysis showed that COX-2 rs20417 polymorphism was correlated with an increased risk of breast cancer in Caucasians, while rs689466 was associated with a decreased risk of breast cancer in Caucasians.
|
25214704 |
2014 |
|
rs5275
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association between each polymorphism and breast cancer risk under the codominant model, dominant model, and recessive model, respectively (nine studies with 6,968 cases and 9,126 controls for rs5275; three studies with 2,901 cases and 3,463 controls for rs20417; two studies with 5,551 cases and 6,208 controls for rs5277).
|
20033767 |
2010 |
|
rs5275
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The rs5275 polymorphism in the 3' untranslated region of the PTGS2 gene was associated with a decrease in breast cancer risk.
|
17214885 |
2007 |
|
rs5277
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In contrast, COX-2 rs5275, rs689466, rs2206593 and rs5277 polymorphisms might be not associated with the risk of breast cancer.
|
25433948 |
2015 |
|
rs5277
|
|
|
0.030 |
GeneticVariation |
BEFREE |
There was suggestive evidence of an interaction between the rs5277 variant in PTGS2 and radiation-related breast cancer risk.
|
20711808 |
2010 |
|
rs5277
|
|
|
0.030 |
GeneticVariation |
BEFREE |
There is a need for further large studies into the role of these polymorphisms (especially rs5277) and other potentially functional polymorphisms/haplotypes in the COX-2 gene as breast cancer</span> risk modifi</span>ers.
|
20033767 |
2010 |
|
rs2206593
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, COX-2 rs5275, rs689466, rs2206593 and rs5277 polymorphisms might be not associated with the risk of breast cancer.
|
25433948 |
2015 |
|
rs373745396
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The 169C>G and 8473T>C polymorphisms of the COX-2 gene were associated with the BC in Egyptian women.
|
23792017 |
2013 |
|
rs4648298
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We genotyped the five most common polymorphisms (rs20417, rs5277, rs20432, rs5275, and rs4648298) in the Nurses' Health Study (1,270 cases, 1,762 controls) to test the hypothesis that polymorphisms in PTGS2 are associated with breast cancer risk, using logistic regression analyses.
|
17214885 |
2007 |