|
rs1314913
|
|
|
0.830 |
GeneticVariation |
BEFREE |
In our study, we evaluted the relation between DNA repair gene polymorphisms XRCC1 rs1799782, rs25487, rs25489; XPC rs2228000, rs2228001; XPD rs1799793, rs13181; XRCC3 rs861539; RAD51B rs10483813, rs1314913 and breast cancer risk for 202 Turkish cases in total, in which 102 patients with breast cancer and 100 controls.
|
28983784 |
2019 |
|
rs1314913
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Common variation on 14q24.1, close to RAD51B, has been associated with breast cancer: rs999737 and rs2588809 with the risk of female breast cancer and rs1314913 with the risk of male breast cancer.
|
27149063 |
2016 |
|
rs1314913
|
|
|
0.830 |
GeneticVariation |
BEFREE |
Furthermore, we showed that the SNPs rs1562430/8q24.21 and rs1314913/14q24.1 strongly influence BC risk in men and suggested that the SNP rs1314913/14q24.1 may act as a risk modifier locus in male BRCA1/2 mutation carriers.
|
26248686 |
2015 |
|
rs2588809
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Common variation on 14q24.1, close to RAD51B, has been associated with breast cancer: rs999737 and rs2588809 with the risk of female breast cancer and rs1314913 with the risk of male breast cancer.
|
27149063 |
2016 |
|
rs2588809
|
|
|
0.820 |
GeneticVariation |
BEFREE |
We observed a significant inverse association (P=8.75 × 10(-6); FDR=0.001) between the risk allele in rs2588809 of the gene RAD51B and TSMC across all breast cancer patients, for both ER(+) and ER(-) tumours.
|
27467053 |
2016 |
|
rs999737
|
|
|
0.770 |
GeneticVariation |
BEFREE |
Common variation on 14q24.1, close to RAD51B, has been associated with breast cancer: rs999737 and rs2588809 with the risk of female breast cancer and rs1314913 with the risk of male breast cancer.
|
27149063 |
2016 |
|
rs999737
|
|
|
0.770 |
GeneticVariation |
BEFREE |
We observed significant association between rs999737 and breast cancer using the allele model (P=2.47E - 35, OR=0.92, 95 % confidence interval (CI) 0.91-0.93).
|
24729084 |
2014 |
|
rs999737
|
|
|
0.770 |
GeneticVariation |
BEFREE |
Seven SNPs were statistically significant (P ≤ 0.05) with the risk of overall breast cancer in the same direction as previously reported: rs10069690 (5p15/TERT), rs999737 (14q24/RAD51L1), rs13387042 (2q35/TNP1), rs1219648 (10q26/FGFR2), rs8170 (19p13/BABAM1), rs17817449 (16q12/FTO), and rs13329835 (16q23/DYL2).
|
23593120 |
2013 |
|
rs999737
|
|
|
0.770 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism (SNP) rs999737 at 14q24.1 was identified as a susceptibility marker of breast cancer in a genome-wide association study of the European population, which was also confirmed by some of the following studies in populations of European descent.
|
22313133 |
2012 |
|
rs999737
|
|
|
0.770 |
GeneticVariation |
BEFREE |
Single-marker association testing and variable-sized sliding-window haplotype analysis were performed, and for both analyses the initial tagging SNP rs999737 retained the strongest association with breast cancer risk.
|
21959381 |
2012 |
|
rs999737
|
|
|
0.770 |
GeneticVariation |
BEFREE |
SNP rs999737 (RAD51L1) was not associated with breast cancer risk for either BRCA1 or BRCA2 mutation carriers (P-trend = 0.27 and 0.30, respectively).
|
21593217 |
2011 |
|
rs999737
|
|
|
0.770 |
GeneticVariation |
BEFREE |
We genotyped 17 germline SNPs (FGFR2-rs2981582, FGFR2-rs3750817, TNRC9-rs3803662, 2q35-rs13387042, MAP3K1-rs889312, 8q24-rs13281615, CASP8-rs1045485, LSP1-rs3817198, COL1A1-rs2075555, COX11-rs6504950, RNF146-rs2180341, 6q25-rs2046210, SLC4A7-rs4973768, NOTCH2-rs11249433, 5p12-rs4415084, 5p12-rs10941679, RAD51L1-rs999737), and odds ratios were estimated by logistic regression to confirm previously reported associations with breast cancer risk.
|
21791674 |
2011 |
|
rs10483813
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In our study, we evaluted the relation between DNA repair gene polymorphisms XRCC1 rs1799782, rs25487, rs25489; XPC rs2228000, rs2228001; XPD rs1799793, rs13181; XRCC3 rs861539; RAD51B rs10483813, rs1314913 and breast cancer risk for 202 Turkish cases in total, in which 102 patients with breast cancer and 100 controls.
|
28983784 |
2019 |
|
rs10483813
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We examined the association of 14 established breast cancer susceptibility loci with mammographic density phenotypes within a large genetic consortium and identified two breast cancer susceptibility variants, LSP1-rs3817198 and RAD51L1-rs10483813, associated with mammographic measures and in the same direction as the breast cancer association.
|
22454379 |
2012 |
|
rs10483813
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We did not find significant variation in the radiation-related breast cancer risk for the variant in RAD51L1 (rs10483813) on 14q24.1 as we had hypothesized.
|
20095854 |
2010 |
|
rs199981178
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified one putatively pathogenic missense mutation c.541C>T among the Finnish cancer patients and subsequently genotyped the mutation in additional breast cancer cases (n = 5259) and population controls (n = 3586) from Finland and Belarus.
|
27149063 |
2016 |
|
rs963917
|
|
|
0.010 |
GeneticVariation |
BEFREE |
NBS1 rs2735383, RAD51 rs963917 and rs963918 were associated with BC risk after stratification according to reproductive factors.
|
25566853 |
2015 |
|
rs963918
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The GC genotype of rs2735383, AG + GG genotype of rs963918 and AC + CC genotype of rs7963551 were associated with PR positivity of BC patients.
|
25566853 |
2015 |
|
rs61755649
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These mutations and variants were detected in families with both breast and ovarian cancers, except for the RAD51B c.475C > T/p.Arg159Cys variant that occurred in a family with 3 breast cancer cases.
|
24139550 |
2013 |
|
rs17828907
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In stage I, two SNPs (rs2842346 and rs17828907) were identified to be significantly associated with breast cancer risk (p=0.030 and 0.027 for genotype distributions, respectively).
|
22313133 |
2012 |
|
rs2842346
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In stage I, two SNPs (rs2842346 and rs17828907) were identified to be significantly associated with breast cancer risk (p=0.030 and 0.027 for genotype distributions, respectively).
|
22313133 |
2012 |