Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1048943
rs1048943
CYP1A1
0.100 GeneticVariation BEFREE Thus, this study gives support to the value of the cytochrome P450 IA1 Ile462Val polymorphism as a practical high-risk marker of lung cancer in populations, especially those in southeast Asia, in which this variant is more common. 9610791

1998
dbSNP: rs587781991
rs587781991
TP53
0.010 GeneticVariation BEFREE To investigate the ability of human lung cancer cells to adequately process and present a mutant p53-derived CTL epitope, we transfected the human cell line HMy-2.C1R and the p53-null human lung cancer cell lines H358 and H1299 with an expression vector containing a human mutant p53 (135 Cys to Tyr). 9816244

1996
dbSNP: rs28934576
rs28934576
TP53
0.030 GeneticVariation BEFREE Modulation of wild-type p53 activity by mutant p53 R273H depends on the p53 responsive element (p53RE). A comparative study between the p53REs of the MDM2, WAFI/Cip1 and Bax genes in the lung cancer environment. WAFI/Cip1 = WAF1/Cip1. 10226602

1999
dbSNP: rs1174612410
rs1174612410
SLC12A9
0.010 GeneticVariation BEFREE Modulation of wild-type p53 activity by mutant p53 R273H depends on the p53 responsive element (p53RE). A comparative study between the p53REs of the MDM2, WAFI/Cip1 and Bax genes in the lung cancer environment. WAFI/Cip1 = WAF1/Cip1. 10226602

1999
dbSNP: rs774352237
rs774352237
TCHP
0.010 GeneticVariation BEFREE Modulation of wild-type p53 activity by mutant p53 R273H depends on the p53 responsive element (p53RE). A comparative study between the p53REs of the MDM2, WAFI/Cip1 and Bax genes in the lung cancer environment. WAFI/Cip1 = WAF1/Cip1. 10226602

1999
dbSNP: rs1695
rs1695
GSTP1
0.100 GeneticVariation BEFREE In this study we have addressed the possible role of the Ile105Val GSTP1 polymorphism in lung cancer susceptibility. 10334644

1999
dbSNP: rs1052133
rs1052133
OGG1 ; CAMK1
0.100 GeneticVariation BEFREE We, therefore, examined allele distributions of the Ser326Cys polymorphism in a case-control study of male lung cancer in Okinawa. 10744126

1999
dbSNP: rs1048943
rs1048943
CYP1A1
0.100 GeneticVariation BEFREE In this Chinese cohort, with CYP1A1 valine allele frequency intermediate between Japanese and Caucasian populations, the I462V polymorphism is not related to lung cancer overall, but it might play a role at lower levels of cigarette smoking among subjects with impaired carcinogen detoxification as assessed by the GSTM1-null genotype. 11008920

2000
dbSNP: rs1042522
rs1042522
TP53
0.100 GeneticVariation BEFREE The amino acid replacement of arginine by proline at codon 72 of TP53 appears not to be important in determining lung cancer risk in this population. 11097227

2000
dbSNP: rs1131691014
rs1131691014
TP53
0.100 GeneticVariation BEFREE The amino acid replacement of arginine by proline at codon 72 of TP53 appears not to be important in determining lung cancer risk in this population. 11097227

2000
dbSNP: rs878854066
rs878854066
TP53
0.100 GeneticVariation BEFREE The amino acid replacement of arginine by proline at codon 72 of TP53 appears not to be important in determining lung cancer risk in this population. 11097227

2000
dbSNP: rs1799782
rs1799782
XRCC1
0.100 GeneticVariation BEFREE Conversely, individuals with the variant Arg194Trp allele who were alcohol drinkers seemed to be at lower risk for lung cancer compared with those with the homozygous wild-type genotype. 11219768

2001
dbSNP: rs25489
rs25489
XRCC1
0.100 GeneticVariation BEFREE In addition, individuals with the variant Arg280His allele who were alcohol drinkers seemed to be at higher risk for lung cancer compared with those with the homozygous wild-type genotype. 11219768

2001
dbSNP: rs1799793
rs1799793
ERCC2
0.100 GeneticVariation BEFREE We therefore examined XPD polymorphisms at Lys751Gln and Asp312Asn in 341 white lung cancer cases and 360 age-, sex-, ethnicity-, and smoking-matched controls accrued in a hospital-based molecular epidemiological study of susceptibility markers for lung cancer. 11245433

2001
dbSNP: rs1217691063
rs1217691063
MTHFR
0.100 GeneticVariation BEFREE However, we found no evidence for an association between the MTHFR C677T and A1298C polymorphisms and risk of lung cancer in either all of the subjects or the low folate intake subgroup; nor did we find evidence for an interaction between these two MTHFR polymorphisms and dietary folate intake or alcohol use. 11319182

2001
dbSNP: rs397507444
rs397507444
MTHFR
0.090 GeneticVariation BEFREE However, we found no evidence for an association between the MTHFR C677T and A1298C polymorphisms and risk of lung cancer in either all of the subjects or the low folate intake subgroup; nor did we find evidence for an interaction between these two MTHFR polymorphisms and dietary folate intake or alcohol use. 11319182

2001
dbSNP: rs369576054
rs369576054
MAPK10 ; ARHGAP24
0.010 GeneticVariation BEFREE Functional characterization of naturally occurring mutants (P405R and P425L) of p73alpha and p73beta found in neuroblastoma and lung cancer. 11429704

2001
dbSNP: rs538874513
rs538874513
TP73
0.010 GeneticVariation BEFREE Functional characterization of naturally occurring mutants (P405R and P425L) of p73alpha and p73beta found in neuroblastoma and lung cancer. 11429704

2001
dbSNP: rs1052133
rs1052133
OGG1 ; CAMK1
0.100 GeneticVariation BEFREE Association of the hOGG1 Ser326Cys polymorphism with lung cancer risk. 11927502

2002
dbSNP: rs121913351
rs121913351
BRAF
A 0.800 CausalMutation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002
dbSNP: rs113488022
rs113488022
BRAF
T 0.750 CausalMutation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002
dbSNP: rs1057519719
rs1057519719
BRAF
C 0.700 CausalMutation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002
dbSNP: rs1057519720
rs1057519720
BRAF
AA 0.700 CausalMutation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002
dbSNP: rs121913355
rs121913355
BRAF
G 0.700 CausalMutation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002
dbSNP: rs121913369
rs121913369
BRAF
C 0.700 CausalMutation CLINVAR Mutations of the BRAF gene in human cancer. 12068308

2002