|
rs1051740
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In the analysis of Tyr113His, the His/His genotype carriers were found to have 29 % higher risk of lung cancer compared to the Tyr/Tyr carriers (His/His vs. Tyr/Tyr, odds ratio, 1.29, 95 % confidence interval, 1.06-1.58).
|
25312477 |
2015 |
|
rs1051740
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Our meta-analysis suggested that the EPHX1 Tyr113His polymorphism may be a risk factor for lung cancer in Asians, whereas it may be a decreased risk factor among Caucasians.
|
25222243 |
2014 |
|
rs1051740
|
|
|
0.080 |
GeneticVariation |
BEFREE |
A comprehensive systematic review and meta-analysis was performed of available studies on these two polymorphisms and cancer risk published up to November 2010, consisting of 84 studies (31144 cases and 42439 controls) for Tyr113His and 77 studies (28496 cases and 38506 controls) for His139Arg primarily focused on lung cancer, upper aerodigestive tract (UADT) cancers (including oral, pharynx, larynx and esophagus cancers), colorectal cancer or adenoma, bladder cancer and breast cancer.
|
21445251 |
2011 |
|
rs1051740
|
|
|
0.080 |
GeneticVariation |
BEFREE |
These findings suggest that the exon 3 Tyr113His and exon 4 His139Arg polymorphisms of EPHXI may be associated with a increased risk of lung cancer and a worse prognosis.
|
21302624 |
2011 |
|
rs1051740
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Binary logistic regression analysis showed association of polymorphism Tyr113His with increased risk of lung cancer (OR = 2.2, 95% CI = 1.2-4.0, p < .05).
|
21649467 |
2011 |
|
rs1051740
|
|
|
0.080 |
GeneticVariation |
BEFREE |
MDR analysis identified two distinct predictor models for the risk of lung cancer in smokers (tobacco chewing, EPHX1 Tyr113His, and SULT1A1 Arg213His) and non-smokers (CYP1A1*2A, GSTP1 Ile105Val and SULT1A1 Arg213His) with testing balance accuracy (TBA) of 0.6436 and 0.6677 respectively.
|
22206016 |
2011 |
|
rs1051740
|
|
|
0.080 |
GeneticVariation |
BEFREE |
However, this study provides some support for the T-Allel of GPX1(Pro200Leu) and the C-Allele of EPHX1(His113Tyr) to play a protective role in early onset lung cancer susceptibility.
|
18298806 |
2008 |
|
rs1051740
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We investigated the roles of EPHX1 Tyr113His and His139Arg polymorphisms in lung cancer susceptibility in a Finnish study population comprising of 230 lung cancer cases and a large control group (n=2105).
|
16005144 |
2006 |
|
rs2234922
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Likewise, His139Arg demonstrated a significant association with lung cancer (Arg/His vs. His/His, odds ratio, 1.2 6, 95 % confidence interval, 1.06-1.49; odds ratio, 1.24, 95 % confidence interval, 1.05-1.46).
|
25312477 |
2015 |
|
rs2234922
|
|
|
0.050 |
GeneticVariation |
BEFREE |
These findings suggest that the exon 3 Tyr113His and exon 4 His139Arg polymorphisms of EPHXI may be associated with a increased risk of lung cancer and a worse prognosis.
|
21302624 |
2011 |
|
rs2234922
|
|
|
0.050 |
GeneticVariation |
BEFREE |
A comprehensive systematic review and meta-analysis was performed of available studies on these two polymorphisms and cancer risk published up to November 2010, consisting of 84 studies (31144 cases and 42439 controls) for Tyr113His and 77 studies (28496 cases and 38506 controls) for His139Arg primarily focused on lung cancer, upper aerodigestive tract (UADT) cancers (including oral, pharynx, larynx and esophagus cancers), colorectal cancer or adenoma, bladder cancer and breast cancer.
|
21445251 |
2011 |
|
rs2234922
|
|
|
0.050 |
GeneticVariation |
BEFREE |
However, only four of the previously reported associations with polymorphisms in the GSTP1 (Ala14Val), SOD2 (Val16Ala), EPHX1 (His139Arg) genes and the NAT1 fast acetylator phenotype remained significantly associated with lung cancer.
|
18258609 |
2008 |
|
rs2234922
|
|
|
0.050 |
GeneticVariation |
BEFREE |
We investigated the roles of EPHX1 Tyr113His and His139Arg polymorphisms in lung cancer susceptibility in a Finnish study population comprising of 230 lung cancer cases and a large control group (n=2105).
|
16005144 |
2006 |
|
rs758244932
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, in the subgroup analysis of Asians, the pooled results suggested that EPHX1 T113C polymorphism was associated with increased risk of lung c</span>ancer under three comparison models, and all P values for the pooled ORs were less than 0.05.There was no risk of publication bias.
|
23378225 |
2013 |