Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10053538
rs10053538
0.010 GeneticVariation BEFREE Furthermore, rs10053538 was associated with lymph node metastasis. 27248321

2016

dbSNP: rs1016343
rs1016343
0.010 GeneticVariation BEFREE In the stratification analyses, the recessive model indicated that the rs1016343 TT genotype was significantly associated with decreased GC risk in individuals aged <60 years showing lymph node metastasis (LNM)-negative results. 31288430

2019

dbSNP: rs10399805
rs10399805
0.010 GeneticVariation BEFREE The CHI3L1 polymorphisms rs10399805 and rs6691378 may act as biomarkers for predicting lymph node metastasis in oral cancer patients. 30341592

2019

dbSNP: rs10420252
rs10420252
0.010 GeneticVariation BEFREE Two SNPs in COX6B1 (complex IV) were associated with lymph node metastasis in a dominant model (rs6510502, OR = 1.75, 95% CI 1.20-2.57; rs10420252, OR = 1.68, 95% CI 1.11-2.53); rs6510502 was associated also with distant metastasis (OR = 1.67, 95% CI 1.09-2.56 in a dominant model). 22545919

2012

dbSNP: rs1042522
rs1042522
0.020 GeneticVariation BEFREE In addition, we showed that BC patients with rs1042522 CC genotype were characterized by only unifocal tumors and decreased frequency of lymph node metastases (p=0.03). 21810023

2011

dbSNP: rs1042522
rs1042522
0.020 GeneticVariation BEFREE Moreover, increased cancer risks were observed for the TP53 Arg72Pro polymorphism in patients with poorly differential status, clinical stage II, and without lymph node metastasis. 26619844

2016

dbSNP: rs1047781
rs1047781
0.010 GeneticVariation BEFREE The sCEA level in rs1047781-T carriers was higher than that in the A carriers in CRC patients without lymph node metastasis (P = 0.006). 24941225

2014

dbSNP: rs104894230
rs104894230
0.010 GeneticVariation BEFREE In sst2+/- mice, PI3K was activated and signaled via AKT (PKB; protein kinase B); when these mice were crossed with KRAS(G12D) mice, premalignant lesions, tumors, and lymph node metastases developed more rapidly than in KRAS(G12D) mice. 25683115

2015

dbSNP: rs10491121
rs10491121
0.010 GeneticVariation BEFREE However, amongst luminal A and luminal B subtypes, compared with patients with the AA genotype, those carrying the AG genotype at SNP rs10491121 were less likely to develop lymph node metastasis. 30123055

2018

dbSNP: rs10505477
rs10505477
0.010 GeneticVariation BEFREE Furthermore, the area under the curve at five years was dramatically increased from 0.619 to 0.624 after adding the rs10505477 risk score to the traditional clinical risk score (TNM stage and lymph node metastasis). 25302443

2015

dbSNP: rs1051740
rs1051740
0.010 GeneticVariation BEFREE Lung cancer patients carrying a heterozygote Tyr113/His 113 genotype had a 2-fold increased risk of lymph node metastases (P = 0.051). 21302624

2011

dbSNP: rs1052133
rs1052133
0.010 GeneticVariation BEFREE We observed a strong association between the G/C genotype of the RAD51-135 G/C polymorphism and the expression of the progesterone receptor and between both alleles of the OGG1-Ser326Cys polymorphism and lymph node metastasis. 18977234

2008

dbSNP: rs1057519847
rs1057519847
0.010 GeneticVariation BEFREE Only one of the patients with an EGFR mutation in the primary HNSCC carried the same mutation (L858R) in the lymph node metastasis. 21953075

2012

dbSNP: rs1057519848
rs1057519848
0.010 GeneticVariation BEFREE Only one of the patients with an EGFR mutation in the primary HNSCC carried the same mutation (L858R) in the lymph node metastasis. 21953075

2012

dbSNP: rs10754339
rs10754339
0.010 GeneticVariation BEFREE Additionally, the rs10754339 GG genotype was significantly associated with lymph node metastasis and PR status, and the G allele and the AG genotype were respectively associated with lymph node metastasis and ER status. 19903360

2009

dbSNP: rs10814325
rs10814325
0.010 GeneticVariation BEFREE In 263 betel quid chewing oral cancer patients, RECK rs10814325 polymorphism have a 2.26-fold (95% CI, 1.19-4.29) risk to have neck lymph node metastasis compared with RECK wild-type carrier. 21565829

2011

dbSNP: rs10877887
rs10877887
0.010 GeneticVariation BEFREE adjusted OR = 0.50, 95% CI = 0.33-0.77, P = 0.001, respectively).Our study suggests that the rs10877887 polymorphism may be associated with the risk of PTC and the rs13293512 polymorphism may correlate to lymph node metastasis in PTC. 26512603

2015

dbSNP: rs10889677
rs10889677
0.010 GeneticVariation BEFREE Patients with oral cancer with at least 1 varied C allele of rs10889677 had a 1.931-fold risk of tumor lymph node metastasis compared with patients with the C/C homozygote. 21717520

2012

dbSNP: rs11064
rs11064
0.010 GeneticVariation BEFREE It also showed that SNP rs11064 was associated with advanced FIGO stage (P = 0.001), deep myometrial invasion (P = 0.047), and lymph node metastasis (P = 0.048) under the codominant model in ECs. 31043860

2019

dbSNP: rs11077
rs11077
0.010 GeneticVariation BEFREE Other clinical features were all considered to have no apparent effect in influencing the prognostic outcomes of advanced NSCLC patients receiving chemotherapy except lymph node metastasis (P < 0.05). miR-SNP rs11077 of XPO5 may be independently connected with the prognosis and chemotherapy response of advanced NSCLC patients, and patients with AC genotype have relatively improved prognostic outcomes and better curative effect of chemotherapy than those with AA allele of XPO5. 26358254

2016

dbSNP: rs11099592
rs11099592
0.010 GeneticVariation BEFREE Haplotype CA in the block composed of rs11099592 and rs4693608 had a greater distribution in the group of Borrmann types 3 and 4 (P = 0.037), the group of a greater number of lymph node metastases (N3 vs N0 group, P = 0.046), and moreover was correlated to poor survival (CG vs CA: HR = 0.645, 95%CI: 0.421-0.989, P = 0.044). 22276173

2012

dbSNP: rs11125
rs11125
0.010 GeneticVariation BEFREE The distribution frequencies of the CC+CA genotype of rs4652 and the AT+TT genotype of rs11125 in the case group were remarkably higher than those in the control group. rs4644 only had correlations with tumor diameter, while rs4652 and rs11125 had correlations with tumor diameter, FIGO staging, differentiation grades, clinical staging, lymph node metastasis (LNM), and treatment modality. 28848207

2017

dbSNP: rs11225395
rs11225395
0.010 GeneticVariation BEFREE Four of the SNPs were found to be associated with lymph node metastasis, the most pronounced being a promoter SNP (rs11225395) with its minor allele (T) associating with reduced susceptibility to lymph node metastasis (P = 0.02). 17974962

2007

dbSNP: rs1130233
rs1130233
0.010 GeneticVariation BEFREE The AKT rs1130233 genotype was found to be associated with clinicopathological parameters including lymph node metastasis and alcohol drinking (P<0.05). 26317520

2015

dbSNP: rs1131691014
rs1131691014
0.010 GeneticVariation BEFREE Moreover, increased cancer risks were observed for the TP53 Arg72Pro polymorphism in patients with poorly differential status, clinical stage II, and without lymph node metastasis. 26619844

2016