|
rs1800562
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The increase in uricemia is associated with the increase in ferritin in a population of patients who were homozygous for the HFE gene mutation p.Cys282Tyr and this independently of factors commonly associated with hyperuricemia.
|
27659401 |
2017 |
|
rs660339
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype A-T (-866G/A-Ala55Val) was a protective factor for hyperuricemia in the female subgroup (OR = 0.80, P = 0.017).
|
27273589 |
2016 |
|
rs3825016
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The frequency of rs3825016 (C/T) CT genotype was significant higher in the hypertensive patients with hyperuricemia than that in the healthy controls (32.7 vs 18.8%; p = 0.02).
|
26086348 |
2015 |
|
rs3825016
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The correlation between rs3825016 polymorphism of SLC22A12 and hyperuricaemia susceptibility is possible.
|
29352852 |
2018 |
|
rs2231142
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The contributions of age, sex, ancestry, Q141K genotype for ABCG2, FCU, sugar-sweetened beverage and alcohol consumption, metabolic syndrome disorders and measures of renal function to the risk of hyperuricaemia were evaluated by comparing hyperuricaemic (serum urate≥0.42 mmol/L, n=448) with normouricaemic (serum urate<0.42 mmol/L, n=344) participants using stepwise logistic regression.
|
26835700 |
2016 |
|
rs4994
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The common polymorphism rs4994 [c. T387C, p. Trp64Arg (W64R)] of the lipolysis regulator beta-3-adrenergic receptor (ADRB3) was identified as a marker in the pathogenesis of hyperuricemia.
|
21285172 |
2011 |
|
rs475688
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study is to explore whether the polymorphisms of rs475688 and rs3825016 in the solute carrier family 22 member 12 (SLC22A12) gene are associated with the susceptibility to gout or hyperuricaemia.
|
29352852 |
2018 |
|
rs2231142
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs2231142 allele G was the protective factor in Uygur hyperuricemia patients.
|
30197413 |
2018 |
|
rs2231142
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs2231142 SNP is associated with serum UA levels and hyperuricemia in Taiwanese patients and it occurs predominantly in male or obese patients.
|
26792383 |
2017 |
|
rs12218
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs12218 SNP in the SAA1 gene was associated with SUA levels in Chinese subjects, indicating that carriers of the T allele of rs12218 have a high risk of hyperuricemia.
|
22768267 |
2012 |
|
rs893006
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs893006 polymorphism in SLC22CA12 was confirmed to be a genetic risk for hyperuricaemia among the Chinese male population.
|
19306160 |
2009 |
|
rs545854
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Stratified analyses also showed a significant association between rs545854 and hyperuricemia among meat eaters (OR = 2.62, 95%CI = 1.09-6.26, <i>P</i> = 0.0308).
|
31031707 |
2019 |
|
rs2544390
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs2544390 also interacts with alcohol consumption in determining hyperuricemia in this population.
|
24286387 |
2013 |
|
rs1217691063
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Results from this study suggest that mutation of 5-MTHFR C677T contributes to the higher uric acid levels in both males and females and may be a risk factor for hyperuricemia.
|
17010581 |
2007 |
|
rs2231142
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Previous studies have suggested an association between hyperuricemia and gout susceptibility relative to dysfunctional ABCG2 variants, with rs2231142 (Q141K) being the most common.
|
30894219 |
2019 |
|
rs559946
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study suggests that the rs559946 polymorphism is associated with increased HUA risk and may also contribute to gout development in Han Chinese men.
|
23981340 |
2014 |
|
rs6903956
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings are the first to establish a genetic link of a CAD-associated rs6903956 with aHU in a Han Chinese population, providing the genetic evidence to support the close relationship between hyperuricemia and CAD.
|
25928384 |
2015 |
|
rs76863441
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multivariate logistic regression analysis with adjustment for age, body mass index, and the prevalence of smoking, hypertension, diabetes mellitus, and hyperuricemia revealed that three polymorphisms [994G --> T (Val279Phe) in the platelet-activating factor acetylhydrolase gene, 242C --> T (His72Tyr) in the NADH/NADPH oxidase p22 phox gene, and 1100C --> T in the apolipoprotein C-III gene] were significantly associated with CAD in men with hypercholesterolemia.
|
14709372 |
2004 |
|
rs763059810
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multivariate logistic regression analysis with adjustment for age, body mass index, and the prevalence of smoking, diabetes mellitus, hypercholesterolemia, and hyperuricemia revealed that 2 polymorphisms (825C-->T in the G protein beta3 subunit gene and 190G-->A in the CC chemokine receptor 2 gene) were significantly associated with hypertension in men and that one polymorphism (-238G-->A in the tumor necrosis factor alpha gene) was significantly associated with hypertension in women.
|
12654703 |
2003 |
|
rs12979860
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multivariate logistic regression analysis showed that age (OR 1.043, 95% CI 1.012-1.075, p=0.007), triglycerides (OR 1.005, 95% CI 1.000-1.010, p=0.04), hyperuricemia (OR 5.027, 95% CI 1.839-13.742, p=0.002), IL28B rs12979860 TT/TC (OR 0.219, 95% CI 0.101-0.472, p<0.001), and steatosis grade (OR 1.704, 95% CI 1.048-2.773, p=0.03) were independently linked to moderate-severe lobular inflammation.
|
22314430 |
2012 |
|
rs3825017
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals carrying the GATAG haplotype (n=32)-a relatively common variant consisting of rs7929627, rs75786299 and rs3825017-showed the highest risk for hyperuricaemia with an OR of 92.23 (p=9.55×10(-3)).
|
26603249 |
2015 |
|
rs7929627
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals carrying the GATAG haplotype (n=32)-a relatively common variant consisting of rs7929627, rs75786299 and rs3825017-showed the highest risk for hyperuricaemia with an OR of 92.23 (p=9.55×10(-3)).
|
26603249 |
2015 |
|
rs75786299
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals carrying the GATAG haplotype (n=32)-a relatively common variant consisting of rs7929627, rs75786299 and rs3825017-showed the highest risk for hyperuricaemia with an OR of 92.23 (p=9.55×10(-3)).
|
26603249 |
2015 |
|
rs6837293
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In SNP genotyping analysis at the neighbourhood regions of marker D4S3243 for the case-control subjects, the polymorphisms rs7688672 and rs6837293, located on the cGMP-dependent protein kinase II (cGK II) gene, were found to relate significantly to gout disease in a recessive model after adjustment of hyperuricaemia (OR = 2.89, 95% CI 1.19 to 7.02 and OR = 2.72, 95% CI 1.13 to 6.54, respectively).
|
18678579 |
2009 |
|
rs7688672
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In SNP genotyping analysis at the neighbourhood regions of marker D4S3243 for the case-control subjects, the polymorphisms rs7688672 and rs6837293, located on the cGMP-dependent protein kinase II (cGK II) gene, were found to relate significantly to gout disease in a recessive model after adjustment of hyperuricaemia (OR = 2.89, 95% CI 1.19 to 7.02 and OR = 2.72, 95% CI 1.13 to 6.54, respectively).
|
18678579 |
2009 |