|
rs12218
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs12218 SNP in the SAA1 gene was associated with SUA levels in Chinese subjects, indicating that carriers of the T allele of rs12218 have a high risk of hyperuricemia.
|
22768267 |
2012 |
|
rs1822825
|
|
|
0.010 |
GeneticVariation |
BEFREE |
BMI, gender, and the rs1822</span>825 polymorphism in the PPARγ gene appeared good biomarkers in hyperuricemia; therefore, these powerful indicators may be included in the prediction of hyperuricemia</span> to increase the accuracy of the analysis.
|
23237621 |
2013 |
|
rs4684846
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three tag-single nucleotide polymorphisms, rs2292101, rs4684846, and rs1822825, of the PPARγ gene were selected to explore their association with hyperuricemia.
|
23237621 |
2013 |
|
rs2231142
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The strongest association was detected at SLC22A12 rs505802 for uric acid (p=2.4×10(-50)) and ABCG2 rs2231142 for hyperuricemia (p3.6×10(-10)).
|
23238572 |
2013 |
|
rs505802
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The strongest association was detected at SLC22A12 rs505802 for uric acid (p=2.4×10(-50)) and ABCG2 rs2231142 for hyperuricemia (p3.6×10(-10)).
|
23238572 |
2013 |
|
rs2231142
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Finally, we have demonstrated the utility of using small molecules to correct the Q141K defect in expression and function as a possible therapeutic approach for hyperuricemia and gout.
|
23493553 |
2013 |
|
rs4994
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Trp64Arg polymorphism was associated with hyperuricemia in a Chinese male population and should be an independent risk factor for hyperuricemia.
|
23729572 |
2013 |
|
rs559946
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study suggests that the rs559946 polymorphism is associated with increased HUA risk and may also contribute to gout development in Han Chinese men.
|
23981340 |
2014 |
|
rs2544390
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs2544390 also interacts with alcohol consumption in determining hyperuricemia in this population.
|
24286387 |
2013 |
|
rs6903956
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings are the first to establish a genetic link of a CAD-associated rs6903956 with aHU in a Han Chinese population, providing the genetic evidence to support the close relationship between hyperuricemia and CAD.
|
25928384 |
2015 |
|
rs3825016
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The frequency of rs3825016 (C/T) CT genotype was significant higher in the hypertensive patients with hyperuricemia than that in the healthy controls (32.7 vs 18.8%; p = 0.02).
|
26086348 |
2015 |
|
rs1529909
|
|
|
0.010 |
GeneticVariation |
BEFREE |
101 hypertensive patients with hyperuricemia were detected the genotypes of URAT1 rs1529909 and rs3825016 and undergo a 2-weeks following losartan treatment.
|
26086348 |
2015 |
|
rs11602903
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The strongest association with hyperuricaemia was observed for rs75786299 (IVS3+11A/G) with an OR of 32.05. rs7929627 (IVS7-103A/G) and rs3825017 (N82N) showed an association with hyperuricaemia with ORs of 2.56 and 2.29, respectively. rs11602903 (788A/T) and rs121907892 (W258X) were negatively correlated with hyperuricaemia with ORs of 0.350 and 0.447, respectively.
|
26603249 |
2015 |
|
rs121907892
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The strongest association with hyperuricaemia was observed for rs75786299 (IVS3+11A/G) with an OR of 32.05. rs7929627 (IVS7-103A/G) and rs3825017 (N82N) showed an association with hyperuricaemia with ORs of 2.56 and 2.29, respectively. rs11602903 (788A/T) and rs121907892 (W258X) were negatively correlated with hyperuricaemia with ORs of 0.350 and 0.447, respectively.
|
26603249 |
2015 |
|
rs3825017
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals carrying the GATAG haplotype (n=32)-a relatively common variant consisting of rs7929627, rs75786299 and rs3825017-showed the highest risk for hyperuricaemia with an OR of 92.23 (p=9.55×10(-3)).
|
26603249 |
2015 |
|
rs75786299
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals carrying the GATAG haplotype (n=32)-a relatively common variant consisting of rs7929627, rs75786299 and rs3825017-showed the highest risk for hyperuricaemia with an OR of 92.23 (p=9.55×10(-3)).
|
26603249 |
2015 |
|
rs7929627
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Individuals carrying the GATAG haplotype (n=32)-a relatively common variant consisting of rs7929627, rs75786299 and rs3825017-showed the highest risk for hyperuricaemia with an OR of 92.23 (p=9.55×10(-3)).
|
26603249 |
2015 |
|
rs130154
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the Uygur population, IL-8 rs4073, IL-18 rs187238 and IL-18RAP rs130154 polymorphisms were all associated with hyperuricemia (P<0.001 by genotype and P=0.008, OR 0.802 by allele for IL-8; P=0.01 by genotype and P=0.006, OR 1.332 by allele for IL-18 rs187238; P=0.007 by genotype and P=0.005, OR 1.27 by allele for IL-18RAP rs130154).
|
26722554 |
2015 |
|
rs187238
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the Kazak population, only IL-18 rs187238 showed statistical significance with hyperuricemia (P=0.002 by genotype and P=0.007, OR 1.823 by allele).
|
26722554 |
2015 |
|
rs4073
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the Uygur population, IL-8 rs4073, IL-18 rs187238 and IL-18RAP rs130154 polymorphisms were all associated with hyperuricemia (P<0.001 by genotype and P=0.008, OR 0.802 by allele for IL-8; P=0.01 by genotype and P=0.006, OR 1.332 by allele for IL-18 rs187238; P=0.007 by genotype and P=0.005, OR 1.27 by allele for IL-18RAP rs130154).
|
26722554 |
2015 |
|
rs2231142
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs2231142 SNP is associated with serum UA levels and hyperuricemia in Taiwanese patients and it occurs predominantly in male or obese patients.
|
26792383 |
2017 |
|
rs2231142
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The contributions of age, sex, ancestry, Q141K genotype for ABCG2, FCU, sugar-sweetened beverage and alcohol consumption, metabolic syndrome disorders and measures of renal function to the risk of hyperuricaemia were evaluated by comparing hyperuricaemic (serum urate≥0.42 mmol/L, n=448) with normouricaemic (serum urate<0.42 mmol/L, n=344) participants using stepwise logistic regression.
|
26835700 |
2016 |
|
rs660339
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The haplotype A-T (-866G/A-Ala55Val) was a protective factor for hyperuricemia in the female subgroup (OR = 0.80, P = 0.017).
|
27273589 |
2016 |
|
rs1800562
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The increase in uricemia is associated with the increase in ferritin in a population of patients who were homozygous for the HFE gene mutation p.Cys282Tyr and this independently of factors commonly associated with hyperuricemia.
|
27659401 |
2017 |
|
rs4148500
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 39 common variants were detected, with an ABCC4 variant (rs4148500) significantly associated with hyperuricemia and gout.
|
28371506 |
2017 |