|
rs1209613132
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ZPBP2 p.T69I was at the non-conserved region and was predicted to be benign by in silico analysis, whereas GPATCH8 p.A979P was at a highly conserved region and was predicted to be deleterious, which made p.A979P a conceivable candidate for juvenile-onset hyperuricemia.
|
21594610 |
2011 |
|
rs753397550
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ZPBP2 p.T69I was at the non-conserved region and was predicted to be benign by in silico analysis, whereas GPATCH8 p.A979P was at a highly conserved region and was predicted to be deleterious, which made p.A979P a conceivable candidate for juvenile-onset hyperuricemia.
|
21594610 |
2011 |
|
rs4073
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the Uygur population, IL-8 rs4073, IL-18 rs187238 and IL-18RAP rs130154 polymorphisms were all associated with hyperuricemia (P<0.001 by genotype and P=0.008, OR 0.802 by allele for IL-8; P=0.01 by genotype and P=0.006, OR 1.332 by allele for IL-18 rs187238; P=0.007 by genotype and P=0.005, OR 1.27 by allele for IL-18RAP rs130154).
|
26722554 |
2015 |
|
rs763059810
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multivariate logistic regression analysis with adjustment for age, body mass index, and the prevalence of smoking, diabetes mellitus, hypercholesterolemia, and hyperuricemia revealed that 2 polymorphisms (825C-->T in the G protein beta3 subunit gene and 190G-->A in the CC chemokine receptor 2 gene) were significantly associated with hypertension in men and that one polymorphism (-238G-->A in the tumor necrosis factor alpha gene) was significantly associated with hypertension in women.
|
12654703 |
2003 |
|
rs142226072
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population.
|
29124443 |
2018 |
|
rs201874364
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population.
|
29124443 |
2018 |
|
rs11554266
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population.
|
29124443 |
2018 |
|
rs5443
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Despite the sufficient statistical power, this study could not demonstrate the significant influence of C825T on hyperuricemia or serum uric acid.
|
16707857 |
2006 |
|
rs727502862
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ZPBP2 p.T69I was at the non-conserved region and was predicted to be benign by in silico analysis, whereas GPATCH8 p.A979P was at a highly conserved region and was predicted to be deleterious, which made p.A979P a conceivable candidate for juvenile-onset hyperuricemia.
|
21594610 |
2011 |
|
rs1800562
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The increase in uricemia is associated with the increase in ferritin in a population of patients who were homozygous for the HFE gene mutation p.Cys282Tyr and this independently of factors commonly associated with hyperuricemia.
|
27659401 |
2017 |
|
rs1555206402
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs2941484
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In men, after adjustments for BMI, SBP, DBP, fasting glucose, total cholesterol, triglycerides, low density lipoprotein cholesterol and creatinine, the men with the TT genotype of rs2941484 were found to have significantly higher probability of suffering from hyperuricemia than the ones with CT and CC genotypes (OR = 2.170, P < 0.001).
|
28460474 |
2017 |
|
rs12979860
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multivariate logistic regression analysis showed that age (OR 1.043, 95% CI 1.012-1.075, p=0.007), triglycerides (OR 1.005, 95% CI 1.000-1.010, p=0.04), hyperuricemia (OR 5.027, 95% CI 1.839-13.742, p=0.002), IL28B rs12979860 TT/TC (OR 0.219, 95% CI 0.101-0.472, p<0.001), and steatosis grade (OR 1.704, 95% CI 1.048-2.773, p=0.03) were independently linked to moderate-severe lobular inflammation.
|
22314430 |
2012 |
|
rs150801101
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population.
|
29124443 |
2018 |
|
rs187238
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For the Kazak population, only IL-18 rs187238 showed statistical significance with hyperuricemia (P=0.002 by genotype and P=0.007, OR 1.823 by allele).
|
26722554 |
2015 |
|
rs143709408
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population.
|
29124443 |
2018 |
|
rs147445322
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population.
|
29124443 |
2018 |
|
rs202007714
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population.
|
29124443 |
2018 |
|
rs200469773
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population.
|
29124443 |
2018 |
|
rs2544390
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs2544390 also interacts with alcohol consumption in determining hyperuricemia in this population.
|
24286387 |
2013 |
|
rs1137070
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also found that MAOA enzyme activity by rs1137070 allele was associated with hyperuricemia and gout (P for trend = 1.53 x 10(-6) vs. wild-type allele).
|
19915868 |
2010 |
|
rs1217691063
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Results from this study suggest that mutation of 5-MTHFR C677T contributes to the higher uric acid levels in both males and females and may be a risk factor for hyperuricemia.
|
17010581 |
2007 |
|
rs1217691063
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Although the mechanism of the relationship between the C677T polymorphism and uric acid still remains unclear, these original articles showed that the MTHFR C677T polymorphism may be an independent risk factor for hyperuricemia.
|
22286863 |
2012 |
|
rs1217691063
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We hypothesized that hyperuricemia would be associated with methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase (TS) 28-bp tandem repeat polymorphism.
|
19917450 |
2009 |
|
rs200933617
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population.
|
29124443 |
2018 |