|
rs17576
|
|
|
0.010 |
GeneticVariation |
BEFREE |
C1562T and R279Q polymorphisms are associated with the susceptibility to premature MI, but cannot predict long-term cardiac events in these patients.
|
28453874 |
2018 |
|
rs10798
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When the mutation groups were combined, the derived SNP haplotype of rs8234 and rs10798 located on the same haplotype with the mutation was associated with a shorter QTc interval (P<0.05) and a reduced occurrence of cardiac events (P<0.01), consistent with the previous finding.
|
27531917 |
2016 |
|
rs8234
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When the mutation groups were combined, the derived SNP haplotype of rs8234 and rs10798 located on the same haplotype with the mutation was associated with a shorter QTc interval (P<0.05) and a reduced occurrence of cardiac events (P<0.01), consistent with the previous finding.
|
27531917 |
2016 |
|
rs11772585
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs11772585 T allele, found uniquely in the TACT haplotype, more than doubled (218%) the risk of cardiac events (P=0.002) in the presence of A341V; additionally, it increased disease severity (P=0.025).
|
25087618 |
2014 |
|
rs12050217
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The efficacy of the ACE (angiotensin-converting enzyme) inhibitor perindopril in coronary artery disease [EUROPA (European trial on reduction of cardiac events with perindopril in stable coronary artery disease) study] is associated with the rs12050217 A/G single nucleotide polymorphism in the B1 receptor (bradykinin type 1 receptor) gene.
|
24117346 |
2014 |
|
rs12720459
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs11772585 T allele, found uniquely in the TACT haplotype, more than doubled (218%) the risk of cardiac events (P=0.002) in the presence of A341V; additionally, it increased disease severity (P=0.025).
|
25087618 |
2014 |
|
rs2282972
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs7808587 GG genotype was associated with a 74% increase in cardiac event risk (P=0.046), whereas the rs2282972 T allele, predominantly represented by the CATT haplotype, decreased risk by 53% (P=0.001).
|
25087618 |
2014 |
|
rs342293
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association between the rs342293 polymorphism and adverse cardiac events in patients undergoing percutaneous coronary intervention.
|
24652536 |
2014 |
|
rs7808587
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs7808587 GG genotype was associated with a 74% increase in cardiac event risk (P=0.046), whereas the rs2282972 T allele, predominantly represented by the CATT haplotype, decreased risk by 53% (P=0.001).
|
25087618 |
2014 |
|
rs2074238
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We provide evidence that the KCNQ1 rs2074238 polymorphism is an independent risk modifier with the minor T-allele conferring protection against cardiac events in patients with LQTS.
|
23856471 |
2013 |
|
rs2106809
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Lone AF males who carry the rs2106809 T allele are associated with adverse cardiac events.
|
24342297 |
2013 |
|
rs12746200
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The PLA2G4A rs12746200 variant also decreased risk of experiencing a major adverse cardiac event (MACE = myocardial infarction, stroke, or death) over 3 years of follow-up (HR = 0.7, 95% CI 0.5-0.9; p = 0.01), consistent with its cardioprotective effect.
|
21293878 |
2011 |
|
rs10494366
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three NOS1AP marker SNPs (rs4657139, rs16847548, and rs10494366) were genotyped to assess the effect of variant alleles on QTc and on the incidence of cardiac events.
|
20538168 |
2010 |
|
rs16847548
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three NOS1AP marker SNPs (rs4657139, rs16847548, and rs10494366) were genotyped to assess the effect of variant alleles on QTc and on the incidence of cardiac events.
|
20538168 |
2010 |
|
rs199472678
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The dominant-negative Y111C-KCNQ1 mutation, associated with a severe phenotype in vitro, presents with a low incidence of life-threatening cardiac events in a Swedish population.
|
20031635 |
2009 |
|
rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate whether C677T polymorphism can be a predictor of major adverse cardiac events after myocardial revascularization.
|
15301885 |
2004 |
|
rs199472742
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Excitement, exercises, and stress appear to be the triggers for developing cardiac events (syncope, sudden death) for LQTS patients with KCNQ1 mutations F275S, S277L, and G306V, and all three KCNH2 mutations L413P, E444D and L559H.
|
12442276 |
2002 |
|
rs199472921
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This mutation, Ala561Thr, in the coding sequence of the fifth membrane-spanning domain (S5) of the HERG protein seems to convey a risk of cardiac events in affected family members.
|
8877771 |
1996 |