We found that the <i>miR-605</i> rs2043556 AG genotype significantly decreased the risk of acute myocardial infarction (odds ratio, OR = 0.13, 95%CI 0.02-0.96, <i>P</i> = .045) and that the rs2043556 GG genotype significantly decreased the risk of unstable angina (OR = 0.19, 95%CI 0.05-0.65, <i>P</i> = .008) in ACS patients receiving clopidogrel therapy for more than one year.