|
rs12185268
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Single-nucleotide polymorphisms in SCARB2 (rs6812193) and MAPT (rs12185268) were significantly associated with RBD.
|
29664058 |
2018 |
|
rs6812193
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Single-nucleotide polymorphisms in SCARB2 (rs6812193) and MAPT (rs12185268) were significantly associated with RBD.
|
29664058 |
2018 |
|
rs12185268
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The SCARB2 rs6812193 (OR = 0.67, 95 % CI = 0.51-0.88, p = 0.004) and the MAPT rs12185268 (OR-0.43, 95 % CI-0.26-0.72, p = 0.001) were associated with RBD in different models.
|
25929833 |
2015 |
|
rs6812193
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The SCARB2 rs6812193 (OR = 0.67, 95 % CI = 0.51-0.88, p = 0.004) and the MAPT rs12185268 (OR-0.43, 95 % CI-0.26-0.72, p = 0.001) were associated with RBD in different models.
|
25929833 |
2015 |
|
rs34311866
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two coding variants, TMEM175 p.M393T (odds ratio [OR] = 1.37, p = 0.0003) and p.Q65P (OR = 0.72, p = 0.005), were associated with PD, and p.M393T was also associated with RBD (OR = 1.59, p = 0.001).
|
31658403 |
2020 |
|
rs34884217
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two coding variants, TMEM175 p.M393T (odds ratio [OR] = 1.37, p = 0.0003) and p.Q65P (OR = 0.72, p = 0.005), were associated with PD, and p.M393T was also associated with RBD (OR = 1.59, p = 0.001).
|
31658403 |
2020 |
|
rs748055361
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two coding variants, TMEM175 p.M393T (odds ratio [OR] = 1.37, p = 0.0003) and p.Q65P (OR = 0.72, p = 0.005), were associated with PD, and p.M393T was also associated with RBD (OR = 1.59, p = 0.001).
|
31658403 |
2020 |
|
rs11175964
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Carriers of the LRRK2 p.N551K-p.R1398H-p.K1423K haplotype have a reduced risk for developing RBD, yet PD-causing mutations probably have minor or no role in RBD.
|
29576439 |
2018 |
|
rs11564148
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A common variant, p.S1647T, was nominally associated with risk for RBD (OR = 1.28, 95% CI 1.05-1.56, p = 0.029).
|
29576439 |
2018 |
|
rs1450426641
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A GBA p.Trp378Gly mutation was identified in two RBD and four PD patients (1% of all patients combined), and not in controls.
|
29920646 |
2018 |
|
rs34637584
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Participants belonging to the following cohorts of the Parkinson Progression Markers Initiative (PPMI) study were included: de novo PD with dopamine transporter binding deficit (n = 423), idiopathic REM sleep behavior disorder (RBD, n = 39), hyposmia (n = 26) and non-PD mutation carrier (NMC; Leucine-rich repeat kinase 2 (LRRK2) G2019S (n = 88) and glucocerebrosidase (GBA) gene (n = 38) mutations)).
|
30125297 |
2018 |
|
rs356219
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Assessments included the RBD screening questionnaire, the extended Consortium to Establish a Registry for Alzheimer's Disease test battery, and genetic testing for the risk variant rs356219 in the alpha-synuclein gene.
|
30048891 |
2018 |
|
rs3756063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
pRBD was associated with rs3756063 located in the 5' region of SNCA (two-sided p = 0.018, odds ratio 1.44).
|
29466944 |
2018 |
|
rs7133914
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Carriers of the LRRK2 p.N551K-p.R1398H-p.K1423K haplotype have a reduced risk for developing RBD, yet PD-causing mutations probably have minor or no role in RBD.
|
29576439 |
2018 |
|
rs7308720
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Carriers of the LRRK2 p.N551K-p.R1398H-p.K1423K haplotype have a reduced risk for developing RBD, yet PD-causing mutations probably have minor or no role in RBD.
|
29576439 |
2018 |
|
rs1045722
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found three SNCA-3'UTR SNPs (rs356165, rs3857053, rs1045722) to be more frequent in PD patients than in iRBD patients (p = 0.014, 0.008, and 0.008, respectively).
|
28409245 |
2017 |
|
rs894278
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, we found that in the group of minor G allele of rs894278, patients with lower score of SS-16 had a 4.76-fold risk of suffering from RBD in patients (95% CI: 1.39-16.67; <i>p</i> = 0.013).
|
28979204 |
2017 |
|
rs1805008
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study does not support a role for the MC1R p.R160W and other variants in susceptibility for PD or RBD.
|
27131830 |
2016 |