Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.050 | GeneticVariation | BEFREE | Our results did not indicate increased risks for CLP among infants homozygous for the C677T genotype, nor do they indicate an interaction between infant C677T genotype and maternal multivitamin use on the occurrence of CLP. | 9843036 | 1998 |
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0.050 | GeneticVariation | BEFREE | Infant and parental MTHFR C677T and MTHFR A1298C genotypes and haplotypes were not associated with CL(P) risk in the case-control and transmission disequilibrium test analyses. | 12672677 | 2003 |
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0.020 | GeneticVariation | BEFREE | Infant and parental MTHFR C677T and MTHFR A1298C genotypes and haplotypes were not associated with CL(P) risk in the case-control and transmission disequilibrium test analyses. | 12672677 | 2003 |
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0.050 | GeneticVariation | BEFREE | The 677 C --> T polymorphism in the 5-10 methylenetetrahydrofolate reductase (MTHFR) gene has been associated with nonsyndromic cleft lip with or without cleft palate (CL/P) in some populations, but not others. | 15054400 | 2004 |
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0.020 | GeneticVariation | BEFREE | MTHFR 677TT alone and IRF6 820GG together with MTHFR 677CT, but not MTHFR A1298C, are risks for nonsyndromic cleft lip with or without cleft palate in an Indian population. | 19419265 | 2009 |
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0.050 | GeneticVariation | BEFREE | Maternal C677T MTHFR genotype has been identified as important factor in cleft lip with or without cleft palate (CL/P) etiology. | 21781437 | 2013 |
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0.010 | GeneticVariation | BEFREE | MTHFR rs2274976 polymorphism is a risk marker for nonsyndromic cleft lip with or without cleft palate in the Brazilian population. | 24254627 | 2014 |
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0.010 | GeneticVariation | BEFREE | rs1801133C>T polymorphism in MTHFR is a risk factor for nonsyndromic cleft lip with or without cleft palate in the Brazilian population. | 25808365 | 2015 |
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0.050 | GeneticVariation | BEFREE | MTHFR c.677C>T is a risk factor for non-syndromic cleft lip with or without cleft palate in Chile. | 27387868 | 2016 |