| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.050 | GeneticVariation | BEFREE | MTHFR c.677C>T is a risk factor for non-syndromic cleft lip with or without cleft palate in Chile. | 27387868 | 2016 |
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0.050 | GeneticVariation | BEFREE | Maternal C677T MTHFR genotype has been identified as important factor in cleft lip with or without cleft palate (CL/P) etiology. | 21781437 | 2013 |
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|
0.050 | GeneticVariation | BEFREE | The 677 C --> T polymorphism in the 5-10 methylenetetrahydrofolate reductase (MTHFR) gene has been associated with nonsyndromic cleft lip with or without cleft palate (CL/P) in some populations, but not others. | 15054400 | 2004 |
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|
0.050 | GeneticVariation | BEFREE | Infant and parental MTHFR C677T and MTHFR A1298C genotypes and haplotypes were not associated with CL(P) risk in the case-control and transmission disequilibrium test analyses. | 12672677 | 2003 |
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|
0.050 | GeneticVariation | BEFREE | Our results did not indicate increased risks for CLP among infants homozygous for the C677T genotype, nor do they indicate an interaction between infant C677T genotype and maternal multivitamin use on the occurrence of CLP. | 9843036 | 1998 |
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|
0.020 | GeneticVariation | BEFREE | MTHFR 677TT alone and IRF6 820GG together with MTHFR 677CT, but not MTHFR A1298C, are risks for nonsyndromic cleft lip with or without cleft palate in an Indian population. | 19419265 | 2009 |
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|
0.020 | GeneticVariation | BEFREE | Infant and parental MTHFR C677T and MTHFR A1298C genotypes and haplotypes were not associated with CL(P) risk in the case-control and transmission disequilibrium test analyses. | 12672677 | 2003 |
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|
0.010 | GeneticVariation | BEFREE | rs1801133C>T polymorphism in MTHFR is a risk factor for nonsyndromic cleft lip with or without cleft palate in the Brazilian population. | 25808365 | 2015 |
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|
0.010 | GeneticVariation | BEFREE | MTHFR rs2274976 polymorphism is a risk marker for nonsyndromic cleft lip with or without cleft palate in the Brazilian population. | 24254627 | 2014 |