rs6265
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our previous work showed an association of the single nucleotide polymorphism (SNP) rs6265 in the BDNF gene with completed suicide in the Slavic population.
|
26462037 |
2015 |
rs6265
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Since our previous work on completed suicide in Slavic population showed an association of the functional single nucleotide polymorphism (SNP) rs6265 in the BDNF gene, we decided to extend the investigation and test additional SNPs in the BDNF gene, rs7124442, rs10767664, rs962369, rs12273363, rs908867, rs1491850, and rs1491851, for association with completed suicide.
|
26115627 |
2015 |
rs6265
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We hypothesized that DNA variants affecting neurodevelopment such as rs4307059 (CDH10/CDH9), rs930752 (NRXN1), rs6265 (BDNF) or rs10868235 (NTRK2) may predispose to completed suicide.
|
22846907 |
2012 |
rs6265
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The meta-analyses of the valine with methionine in codon 66 (Val66Met) single nucleotide polymorphism (SNP) showed that the Met-allele tended to be associated with attempted suicide in Asian populations, but not with the completed suicide.
|
23850432 |
2013 |
rs3800373
|
|
|
0.030 |
GeneticVariation |
BEFREE |
When we analyzed suicidal behavior, we found a significant association with the rs1360780 of FKBP5 and suicidal behavior risk in the overall population and rs3800373 in completed suicide subgroup.
|
30791339 |
2019 |
rs3800373
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The distributions of TT, TC, and GT haplotypes of the FKBP5 gene (comprised of rs3800373 and rs1360780) between the completed suicide and control groups were significantly different (p<0.05 for each haplotype).
|
21112363 |
2011 |
rs3800373
|
|
|
0.030 |
GeneticVariation |
BEFREE |
A significant association between the high-induction rs3800373 C allele and completed suicide was detected (OR = 1.36, p = 0.007).
|
26630184 |
2015 |
rs1360780
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The distributions of TT, TC, and GT haplotypes of the FKBP5 gene (comprised of rs3800373 and rs1360780) between the completed suicide and control groups were significantly different (p<0.05 for each haplotype).
|
21112363 |
2011 |
rs1360780
|
|
|
0.020 |
GeneticVariation |
BEFREE |
When we analyzed suicidal behavior, we found a significant association with the rs1360780 of FKBP5 and suicidal behavior risk in the overall population and rs3800373 in completed suicide subgroup.
|
30791339 |
2019 |
rs1799971
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A recent genetic association study in a sample of suicide victims reported a protective effect of the G allele of Asn40Asp (rs1799971) on risk for completed suicide.
|
22211341 |
2012 |
rs1799971
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The genotypic and allelic distributions of the A118G SNP were significantly different between the completed suicide and control groups (P = 0.014 and 0.039, respectively).
|
18250953 |
2008 |
rs10416814
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We studied 5 SNPs including one SNP in exon 2 (rs3745459) and four SNPs in the potential promoter region of the EP1 gene (rs3810255, rs3810254, rs3810253 and rs10416814) in 374 healthy control and 287 completed suicide victims using standard Taqman probe genotyping assays.
|
21447366 |
2011 |
rs10767664
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis (rs7124442-rs10767664-rs962369-rs12273363-rs908867) showed an association of the haplotype C-A-T-C-C (p(corr)=0.038) with completed suicide, indicating that these SNPs on a haplotype level may play a role in completed suicide phenotype in our study sample.
|
26115627 |
2015 |
rs10868235
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We hypothesized that DNA variants affecting neurodevelopment such as rs4307059 (CDH10/CDH9), rs930752 (NRXN1), rs6265 (BDNF) or rs10868235 (NTRK2) may predispose to completed suicide.
|
22846907 |
2012 |
rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We conclude that MTHFR C677T polymorphism is not a risk factor for completed suicide.
|
22982411 |
2012 |
rs121908538
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, additional association tests yielded four significant PsychArray variants (SP110, rs181058279; AGBL2, rs76215382; SUCLA2, rs121908538; APH1B, rs745918508), raising the likelihood that these genes confer risk of completed suicide.
|
30353169 |
2018 |
rs12273363
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analysis (rs7124442-rs10767664-rs962369-rs12273363-rs908867) showed an association of the haplotype C-A-T-C-C (p(corr)=0.038) with completed suicide, indicating that these SNPs on a haplotype level may play a role in completed suicide phenotype in our study sample.
|
26115627 |
2015 |
rs1491850
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Since our previous work on completed suicide in Slavic population showed an association of the functional single nucleotide polymorphism (SNP) rs6265 in the BDNF gene, we decided to extend the investigation and test additional SNPs in the BDNF gene, rs7124442, rs10767664, rs962369, rs12273363, rs908867, rs1491850, and rs1491851, for association with completed suicide.
|
26115627 |
2015 |
rs1491851
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Since our previous work on completed suicide in Slavic population showed an association of the functional single nucleotide polymorphism (SNP) rs6265 in the BDNF gene, we decided to extend the investigation and test additional SNPs in the BDNF gene, rs7124442, rs10767664, rs962369, rs12273363, rs908867, rs1491850, and rs1491851, for association with completed suicide.
|
26115627 |
2015 |
rs1532976
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We used three high-frequency SNPs (rs1532976, rs3752826, and rs9393) and found a significant association of two alleles (rs1532976 and rs3752826) with completed suicide (p < 0.05).
|
15838597 |
2005 |
rs1800042
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To explore the hypothesis that the 5-HT1A receptor-induced serotonergic dysfunction is implicated genetically in suicide, we focused on the structural polymorphisms, Pro16Leu and Gly272Asp, of the 5-HT1A receptor gene, and examined the association between suicide victims who completed suicide and these two polymorphisms.
|
11992564 |
2002 |
rs1801133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MTHFR C677T polymorphism (rs1801133) was associated with numerous psychiatric conditions but no prior study investigated whether it predisposes to completed suicide.
|
22982411 |
2012 |
rs181058279
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, additional association tests yielded four significant PsychArray variants (SP110, rs181058279; AGBL2, rs76215382; SUCLA2, rs121908538; APH1B, rs745918508), raising the likelihood that these genes confer risk of completed suicide.
|
30353169 |
2018 |
rs2682826
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that both the genotypic distribution and the allelic frequencies of rs2682826 SNP were significantly different between the completed suicide and control groups (P=0.0007 and 0.0005, respectively).
|
20470850 |
2010 |
rs3752826
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We used three high-frequency SNPs (rs1532976, rs3752826, and rs9393) and found a significant association of two alleles (rs1532976 and rs3752826) with completed suicide (p < 0.05).
|
15838597 |
2005 |