|
rs1041983
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNPs in NAT2 (rs1041983 and rs1495741) and NAT2 slow acetylators (SA) were significantly associated with INH-DILI (OR (95% CI) = 13.86 (4.30-44.70), 0.10 (0.03-0.33) and 9.98 (3.32-33.80), respectively).
|
29036176 |
2017 |
|
rs1050450
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We have evaluated possible associations between the risk of developing DILI and common genetic variants of the manganese superoxide dismutase (SOD2 Val16Ala) and glutathione peroxidase (GPX1 Pro200Leu) genes, which are involved in mitochondrial oxidative stress management.
|
20578157 |
2010 |
|
rs10946737
|
|
|
0.010 |
GeneticVariation |
BEFREE |
On the basis of this case-control study, SNP rs10946737 in FAM65B may be associated with susceptibility to ATDH in Chinese Han anti-TB treatment patients.
|
30720667 |
2019 |
|
rs114577328
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We associated DILI with rs114577328 (a proxy for A*33:01 a HLA class I allele; odds ratio [OR], 2.7; 95% confidence interval [CI], 1.9-3.8; P = 2.4 × 10<sup>-8</sup>) and with rs72631567 on chromosome 2 (OR, 2.0; 95% CI, 1.6-2.5; P = 9.7 × 10<sup>-9</sup>).
|
28043905 |
2017 |
|
rs116561224
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We did not associate any specific drug classes with genetic polymorphisms, except for statin-associated DILI, which was associated with rs116561224 on chromosome 18 (OR, 5.4; 95% CI, 3.0-9.5; P = 7.1 × 10<sup>-9</sup>).
|
28043905 |
2017 |
|
rs117806152
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Rs79280755 increased the risk of ATDILI significantly whether in additive (OR = 3.218, 95% CI: 1.686-6.139, PBonferroni correction = .003) or dominant model (PBonferroni correction = .003), as well as rs117806152 (Additive model: PBonferroni correction = .05; dominant model: PBonferroni correction = .03).
|
31689868 |
2019 |
|
rs1214110864
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four highly conserved nonsynonymous mutations were specific for drug-induced liver injury [ABCB11: D676Y (drug-induced cholestasis) and G855R (drug-induced cholestasis); ABCB4: I764L (drug-induced cholestasis) and L1082Q (drug-induced hepatocellular injury)].
|
17264802 |
2007 |
|
rs138642043
|
|
|
0.010 |
GeneticVariation |
BEFREE |
On sequencing, ATP8B1 was normal in both patients although the younger was heterozygous for the c.2093G>A mutation in ABCB11, a polymorphism previously encountered in drug-induced liver injury.
|
23750872 |
2013 |
|
rs1495741
|
|
|
0.030 |
GeneticVariation |
BEFREE |
tagSNP rs1495741 as a useful molecular marker to predict antituberculosis drug-induced hepatotoxicity.
|
27104815 |
2016 |
|
rs1495741
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The NAT2 tag SNP rs1495741 correlates with the susceptibility of antituberculosis drug-induced hepatotoxicity.
|
23407048 |
2013 |
|
rs1495741
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Two SNPs in NAT2 (rs1041983 and rs1495741) and NAT2 slow acetylators (SA) were significantly associated with INH-DILI (OR (95% CI) = 13.86 (4.30-44.70), 0.10 (0.03-0.33) and 9.98 (3.32-33.80), respectively).
|
29036176 |
2017 |
|
rs17036170
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs.
|
22968431 |
2012 |
|
rs1800796
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs1800796 of the IL6 gene is associated with increased risk for anti-tuberculosis drug-induced hepatotoxicity in Chinese Han children.
|
30029918 |
2018 |
|
rs1966862
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study suggested rs1966862 (ARHGAP24) and the other SNPs to be predictive factors for drug-induced hepatotoxicity during the maintenance phase in pediatric patients with ALL or LBL.
|
20670164 |
2010 |
|
rs2287622
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A common variant (rs2287622; p.V444A) in the gene encoding BSEP has been associated with an increased risk of cholestatic DILI.
|
30608704 |
2019 |
|
rs2287622
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Patients carrying the C allele in the ABCB11 1331T>C polymorphism are at increased risk of developing hepatocellular type of DILI, when taking drugs containing a carbocyclic system with aromatic rings.
|
23701583 |
2013 |
|
rs2306283
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that rs12422149 of SLCO2B1, rs2032582_AT of ABCB1, rs2306283 of SLCO1B1 and rs4148323 of UGT1A1 exhibited a significant association with MMI-DILI; however, no significant difference existed after Bonferroni correction.
|
31240859 |
2019 |
|
rs231775
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant association was found between the rs231775 genotype and an early onset of DILI in the recipients.
|
23300559 |
2012 |
|
rs2476601
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We associated idiosyncratic DILI with rs2476601, a nonsynonymous polymorphism that encodes a substitution of tryptophan with arginine in the protein tyrosine phosphatase, nonreceptor type 22 gene (PTPN22) (odds ratio [OR] 1.44; 95% confidence interval [CI] 1.28-1.62; P = 1.2 × 10<sup>-9</sup> and replicated the finding in the validation set (OR 1.48; 95% CI 1.09-1.99; P = .01).
|
30664875 |
2019 |
|
rs2741045
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed statistically significant associations between SNP rs2741045 and DILI at</span> both allele and genotype levels (allele: P=0.032; genotype: P=0.029; after Bonferroni correction).
|
25446781 |
2015 |
|
rs3087243
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the association of 5 CTLA4 single-nucleotide polymorphisms (SNPs) (rs733618 C/T, rs4553808 A/G, rs5742909 C/T, rs231775 A/G, and rs3087243 G/A) with drug-induced liver injury (DILI) in Chinese renal transplantation (RT) recipients.
|
23300559 |
2012 |
|
rs3135388
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The strongest effect was with an HLA class II SNP (rs9274407, P=4.8×10(-14)), which correlated with rs3135388, a tag SNP of HLA-DRB1*1501-DQB1*0602 that was previously associated with AC-DILI.
|
21570397 |
2011 |
|
rs4148323
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that rs12422149 of SLCO2B1, rs2032582_AT of ABCB1, rs2306283 of SLCO1B1 and rs4148323 of UGT1A1 exhibited a significant association with MMI-DILI; however, no significant difference existed after Bonferroni correction.
|
31240859 |
2019 |
|
rs4430924
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correcting for weight and hepatoprotectant use, conditional logistic regression analysis showed that patients carrying the AA genotype of rs4430924 in</span> XPO1 were at higher risk of anti-TB drug-induced hepatotoxicity than those carrying the GG genotype based on the subgroup of probable cases (adjusted OR, 1.938; 95%CI, 1.035-3.628; P = .039), and marginally significant differences were also found under the recessive model (P = .048) and the additive model (P = .047).
|
30817003 |
2019 |
|
rs4553808
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated the association of 5 CTLA4 single-nucleotide polymorphisms (SNPs) (rs733618 C/T, rs4553808 A/G, rs5742909 C/T, rs231775 A/G, and rs3087243 G/A) with drug-induced liver injury (DILI) in Chinese renal transplantation (RT) recipients.
|
23300559 |
2012 |